1 Dissertation_Ali_2012.pdf 2036552 46084543b56ab7abf59360b8f8e6ffa0 rosdok/id00001000 718223721 MODS updated during RosDok migration in June 2021 Dissertation Hochschulschrift 1023711575 Iftikhar Ali 1984- VerfasserIn aut Synthesis of Substituted 1-Deazapurines via Pd/Cu Catalysed C-H Activation, Substituted Naphthyridines, Quinoxalines, and Trifluoromethyl-Substituted Arenes by Pd(0)-Catalysed Cross-Coupling Reactions en Prof. Dr. Peter Langer AkademischeR BetreuerIn dgs Prof. Dr. Ulrike Lindequist AkademischeR BetreuerIn dgs 2147083-2 Universität Rostock Mathematisch-Naturwissenschaftliche Fakultät Grad-verleihende Institution dgg 10.18453/rosdok_id00001000 http://purl.uni-rostock.de/rosdok/id00001000 urn:nbn:de:gbv:28-diss2012-0039-6 540 Chemie Mathematisch-Naturwissenschaftliche Fakultät frei zugänglich (Open Access) Lizenz Metadaten: CC0 Nutzungsrechte erteilt alle Rechte vorbehalten Universität Rostock Rostock 2011 monographic 2012 2011 Universitätsbibliothek Rostock Rostock 2012 2012 The Pd/Cu catalyzed reactions of 3H-imidazo[4,5-b]pyridines (1-deazapurines) via C-H bond activation provided arylated 1-deazapurines. The arylation took place at position 2 of the 1-deazapurines. Pd(0)-catalysed Suzuki-Miyaura cross coupling reactions of 5,7-dichloro-1,6-naphthyridine, 2,6-dichloroquinoxaline and 2,4-dichloro-1-(trifluoromethyl)benzene with different arylboronic acids afforded aryl-substituted naphthyridines, quinoxalines and trifluoromethyl-substituted di- and terphenyls with excellent site-selectivity. The first attack occurred at the more electronically deficient and sterically less hindered position. Die Pd/Cu-katalysierten Reaktionen von 3H-Imidazo[4,5-b]pyridinen (1-Desazapurinen) via C-H-Aktivierung lieferten arylierte 1-Deazapurine. Die Arylierung fand an Position 2 des 1-Desazapurins statt. Suzuki-Miyaura-Kupplungen von 5,7-Dichlor-1,6-naphthyridin, 2,6-Dichlorchinoxalin und 2,4-Dichlor-1-(trifluormethyl)benzol mit verschiedenen Arylboronsäuren ergab arylsubstituierte Naphthyridine, Chinoxaline, Trifluormethyl-substituierte Biphenyle und Terphenyle mit ausgezeichneter Regioselektivität. Der erste Angriff erfolgte an der elektronisch ärmeren und sterisch weniger gehinderten Position. Deazapurines CH activation Pd(0) catalysis Universitätsbibliothek Rostock http://purl.uni-rostock.de/rosdok/id00001000 2012-06-26T11:27:45.990Z 2023-08-08T10:03:19.564Z 2023-08-18T10:03:19.568Z {"identifier":"rosdok/id00001000","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T12:57:05.821Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001000","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T12:57:05.969Z","registered":"2018-06-30T12:57:05.969Z"} {"identifier":"10.18453/rosdok_id00001000","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T12:57:07.263Z","registered":"2018-06-30T12:57:07.263Z"} {"identifier":"urn:nbn:de:gbv:28-diss2012-0039-6","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T12:57:05.826Z","registered":"2012-06-27T02:14:32.090Z"} administrator