mycoreobjectrosdok_disshab_0000000877rosdok_disshab_0000000877rosdokdisshabrosdok_derivate_00000049322023-08-08T10:03:35.724Z2012-10-29T13:26:51.418Zadministratorpublished1rosdok_derivate_0000004932truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id0000105672880977XMODS updated during RosDok migration in June 2021DissertationHochschulschrift1027084400NadezdaZhuravleva1984-VerfasserInautKCNQ channel opening as a powerful mechanism for vasodilationenProf. Dr. med.RudolfSchubertAkademischeR BetreuerIndgsProf. Dr. med. Dr. rer. nat.MaikGollaschAkademischeR BetreuerIndgsProf. Dr. med.OlafGriskAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001056http://purl.uni-rostock.de/rosdok/id00001056urn:nbn:de:gbv:28-diss2012-0095-9610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2011monographic20122011Universitätsbibliothek RostockRostock20122012KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.Kv7KCNQ channel openermyographyGracilis arteryintrapulmonary arteryUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001056doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. 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Rudolf SchubertProf. Dr. med. Rudolf Schubertrosdok_disshab_0000000877-d38776e72Prof. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Dr. rer. nat. Maik Gollaschrosdok_disshab_0000000877-d38776e84Prof. Dr. med. Olaf GriskProf. Dr. med. Olaf Griskrosdok_disshab_0000000877-d38776e97gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaProf. Dr. med. Rudolf SchubertProf. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Olaf GriskUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaProf. Dr. med. Rudolf SchubertProf. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Olaf GriskUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001056http://purl.uni-rostock.de/rosdok/id00001056urn:nbn:de:gbv:28-diss2012-0095-9Kv7KCNQ channel openermyographyGracilis arteryintrapulmonary arteryKCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.20112011epub.dissertation1 Dissertation_Zhuravleva_2012.pdf 1750070 da2fdb803195870b754c5fe26fe67497 rosdok/id0000105672880977XMODS updated during RosDok migration in June 2021DissertationHochschulschrift1027084400NadezdaZhuravleva1984-VerfasserInautKCNQ channel opening as a powerful mechanism for vasodilationenProf. Dr. med.RudolfSchubertAkademischeR BetreuerIndgsProf. Dr. med. 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Rudolf SchubertProf. Dr. med. Rudolf Schubertrosdok_disshab_0000000877-d38776e72Prof. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Dr. rer. nat. Maik Gollaschrosdok_disshab_0000000877-d38776e84Prof. Dr. med. Olaf GriskProf. Dr. med. Olaf Griskrosdok_disshab_0000000877-d38776e97gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaProf. Dr. med. Rudolf SchubertProf. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Olaf GriskUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaProf. Dr. med. Rudolf SchubertProf. Dr. med. Dr. rer. nat. Maik GollaschProf. Dr. med. Olaf GriskUniversität Rostock UniversitätsmedizinNadezda ZhuravlevaRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001056http://purl.uni-rostock.de/rosdok/id00001056urn:nbn:de:gbv:28-diss2012-0095-9Kv7KCNQ channel openermyographyGracilis arteryintrapulmonary arteryKCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ channels mediate vessel relaxation induced by experimental modulators in systemic and pulmonary circulation, in normo- and hypertensive model. Conclusion: KCNQ channels could be powerful targets for vessel relaxation, also in pathological hypertensive conditions.20112011[xslt]Saxonrosdok/id00001056https://purl.uni-rostock.de/rosdok/id0000105672880977X10.18453/rosdok_id00001056urn:nbn:de:gbv:28-diss2012-0095-9Nadezda ZhuravlevaZhuravleva NadezdaKCNQ channel opening as a powerful mechanism for vasodilationDissertationdoctoral thesisUniversität Rostock, 2011KCNQ channels were recently found in the vascular system. We have tested the hypothesis that KCNQ channels are powerful targets for relaxation of small systemic and pulmonary arteries. In rat Gracilis arteries we found mRNA expression for KCNQ1, KCNQ3, KCNQ4 and KCNQ5 channels. We found that KCNQ…Nadezda ZhuravlevaKCNQ channel opening as a powerful mechanism for vasodilationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000010561027084400NadezdaZhuravleva1984-VerfasserInautProf. Dr. med.RudolfSchubertAkademischeR BetreuerIndgsProf. Dr. med. Dr. rer. nat.MaikGollaschAkademischeR BetreuerIndgsProf. Dr. med.OlafGriskAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001056[purl]http://purl.uni-rostock.de/rosdok/id00001056[urn]urn:nbn:de:gbv:28-diss2012-0095-9open_access20112011epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.umrstate:published