mycoreobjectrosdok_disshab_0000001061rosdok_disshab_0000001061rosdokdisshabrosdok_derivate_00000051802023-08-08T10:04:27.138Z2013-11-01T17:11:48.430Zadministratorpublished1rosdok_derivate_0000005180truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001240772632693MODS updated during RosDok migration in June 2021DissertationHochschulschrift1025918991RosaelyCasalegno Garduño1982-VerfasserInautExpression of and immune responses to leukemia antigens in patients with hematological malignanciesenProf. Dr. med.MichaelSchmittUniversitätsklinikum Heidelberg, Zelluläre Immunotherapie, Medizinische Klinik VAkademischeR BetreuerIndgs143434314Prof. Dr. rer. nat.ReinhardSchröderUniversität Rostock, Institut für Biowissenschaften, Abt. GenetikAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001240http://purl.uni-rostock.de/rosdok/id00001240urn:nbn:de:gbv:28-diss2013-0153-1610 Medizin, Gesundheit570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2013monographic20122013Universitätsbibliothek RostockRostock20132013Leukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level using qPCR before and after treatment. 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Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Expression of and immune responses to leukemia antigens in patients with hematological malignanciesExpression of and immune responses to leukemia antigens in patients with hematological malignanciesgnd:1025918991gnd:143434314gnd:2147083-2gnd:1025918991gnd:143434314gnd:2147083-2rosdok_disshab_0000001061-d1193741e39gnd:1025918991Rosaely Casalegno GarduñoRosaely Casalegno Garduñorosdok_disshab_0000001061-d1193741e60Prof. Dr. med. Michael SchmittProf. Dr. med. Michael Schmittrosdok_disshab_0000001061-d1193741e73gnd:143434314Prof. Dr. rer. nat. Reinhard SchröderProf. Dr. rer. nat. Reinhard Schröderrosdok_disshab_0000001061-d1193741e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoProf. Dr. med. Michael SchmittProf. Dr. rer. nat. Reinhard SchröderUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoProf. Dr. med. Michael SchmittProf. Dr. rer. nat. Reinhard SchröderUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001240http://purl.uni-rostock.de/rosdok/id00001240urn:nbn:de:gbv:28-diss2013-0153-1RHAMMWT1T cell responseLeukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level using qPCR before and after treatment. 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We concluded that WT1 is a suitable marker for MRD after allogeneic SCT and that a WT1-specific T cell response might contribute to the maintenance of CR.RHAMMWT1T cell responseUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001240 2013-11-01T17:11:48.430Z 2023-08-08T10:04:27.138Z 2023-08-18T10:04:27.143Z {"identifier":"rosdok/id00001240","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:05:30.453Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001240","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:05:30.645Z","registered":"2018-06-30T13:05:30.645Z"} {"identifier":"10.18453/rosdok_id00001240","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:05:31.957Z","registered":"2018-06-30T13:05:31.957Z"} {"identifier":"urn:nbn:de:gbv:28-diss2013-0153-1","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:05:30.459Z","registered":"2013-11-29T03:13:08.917Z"} administratorfulltextfile/rosdok_disshab_0000001061/rosdok_derivate_0000005180/Dissertation_Casalegno_2013.pdfExpression of and immune responses to leukemia antigens in patients with hematological malignanciesExpression of and immune responses to leukemia antigens in patients with hematological malignanciesgnd:1025918991gnd:143434314gnd:2147083-2gnd:1025918991gnd:143434314gnd:2147083-2rosdok_disshab_0000001061-d1193741e39gnd:1025918991Rosaely Casalegno GarduñoRosaely Casalegno Garduñorosdok_disshab_0000001061-d1193741e60Prof. Dr. med. Michael SchmittProf. Dr. med. Michael Schmittrosdok_disshab_0000001061-d1193741e73gnd:143434314Prof. Dr. rer. nat. Reinhard SchröderProf. Dr. rer. nat. Reinhard Schröderrosdok_disshab_0000001061-d1193741e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoProf. Dr. med. Michael SchmittProf. Dr. rer. nat. Reinhard SchröderUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoProf. Dr. med. Michael SchmittProf. Dr. rer. nat. Reinhard SchröderUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätRosaely Casalegno GarduñoRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001240http://purl.uni-rostock.de/rosdok/id00001240urn:nbn:de:gbv:28-diss2013-0153-1RHAMMWT1T cell responseLeukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We investigated the expression of WT1 and RHAMM at RNA level using qPCR before and after treatment. We concluded that WT1 is a suitable marker for MRD after allogeneic SCT and that a WT1-specific T cell response might contribute to the maintenance of CR.20132013[xslt]Saxonrosdok/id00001240https://purl.uni-rostock.de/rosdok/id0000124077263269310.18453/rosdok_id00001240urn:nbn:de:gbv:28-diss2013-0153-1Rosaely Casalegno GarduñoCasalegno Garduño RosaelyExpression of and immune responses to leukemia antigens in patients with hematological malignanciesDissertationdoctoral thesisUniversität Rostock, 2013Leukemia cells are characterized by differentially expressed leukemia-associated antigens (LAAs). We wondered whether the expression of the LAAs WT1 and RHAMM as well as the T cellular immune response to these LAAs correlated with the clinical outcome of patients suffering from leukemia. We…Rosaely Casalegno GarduñoExpression of and immune responses to leukemia antigens in patients with hematological malignanciesUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000012401025918991RosaelyCasalegno Garduño1982-VerfasserInautProf. Dr. med.MichaelSchmittUniversitätsklinikum Heidelberg, Zelluläre Immunotherapie, Medizinische Klinik VAkademischeR BetreuerIndgs143434314Prof. Dr. rer. nat.ReinhardSchröderUniversität Rostock, Institut für Biowissenschaften, Abt. GenetikAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001240[purl]http://purl.uni-rostock.de/rosdok/id00001240[urn]urn:nbn:de:gbv:28-diss2013-0153-1open_access20132013epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610SDNB:570institution:unirostock.mnfstate:published