mycoreobjectrosdok_disshab_0000001067rosdok_disshab_0000001067rosdokdisshabrosdok_derivate_00000051762023-08-08T10:04:28.862Z2013-11-05T11:53:47.262Zadministratorpublished1rosdok_derivate_0000005176truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001246772571481MODS updated during RosDok migration in June 2021DissertationHochschulschriftLijoJohn1979-VerfasserInautIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusen1016003706Prof. Dr. med.StephanSchaeferUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs132475170Prof. Dr. rer. nat.HubertBahlUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001246http://purl.uni-rostock.de/rosdok/id00001246urn:nbn:de:gbv:28-diss2013-0159-8570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2013monographic20112013Universitätsbibliothek RostockRostock20132013Investigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.microarrayNS4Bhost factors hepatitis E virusORF2ER stressanti-apoptotic heat schock proteinsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001246doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Identification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusgnd:1016003706gnd:132475170gnd:2147083-2gnd:1016003706gnd:132475170gnd:2147083-2rosdok_disshab_0000001067-d1135188e39Lijo JohnLijo Johnrosdok_disshab_0000001067-d1135188e59gnd:1016003706Prof. Dr. med. Stephan SchaeferProf. Dr. med. Stephan Schaeferrosdok_disshab_0000001067-d1135188e74gnd:132475170Prof. Dr. rer. nat. Hubert BahlProf. Dr. rer. nat. Hubert Bahlrosdok_disshab_0000001067-d1135188e89gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnProf. Dr. med. Stephan SchaeferProf. Dr. rer. nat. Hubert BahlUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnProf. Dr. med. Stephan SchaeferProf. Dr. rer. nat. Hubert BahlUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001246http://purl.uni-rostock.de/rosdok/id00001246urn:nbn:de:gbv:28-diss2013-0159-8microarrayNS4Bhost factors hepatitis E virusORF2ER stressanti-apoptotic heat schock proteinsInvestigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.20132013epub.dissertation1 Dissertation_John_2013.pdf 3531317 45e4ef5779f04794123606f20dd8afdd rosdok/id00001246772571481MODS updated during RosDok migration in June 2021DissertationHochschulschriftLijoJohn1979-VerfasserInautIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusen1016003706Prof. Dr. med.StephanSchaeferUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs132475170Prof. Dr. rer. nat.HubertBahlUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001246http://purl.uni-rostock.de/rosdok/id00001246urn:nbn:de:gbv:28-diss2013-0159-8570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2013monographic20112013Universitätsbibliothek RostockRostock20132013Investigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.microarrayNS4Bhost factors hepatitis E virusORF2ER stressanti-apoptotic heat schock proteinsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001246 2013-11-05T11:53:47.262Z 2023-08-08T10:04:28.862Z 2023-08-18T10:04:28.866Z {"identifier":"rosdok/id00001246","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:05:42.296Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001246","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:05:42.490Z","registered":"2018-06-30T13:05:42.490Z"} {"identifier":"10.18453/rosdok_id00001246","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:05:43.775Z","registered":"2018-06-30T13:05:43.775Z"} {"identifier":"urn:nbn:de:gbv:28-diss2013-0159-8","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:05:42.301Z","registered":"2013-11-29T03:13:18.507Z"} administratorfulltextfile/rosdok_disshab_0000001067/rosdok_derivate_0000005176/Dissertation_John_2013.pdfIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusgnd:1016003706gnd:132475170gnd:2147083-2gnd:1016003706gnd:132475170gnd:2147083-2rosdok_disshab_0000001067-d1135188e39Lijo JohnLijo Johnrosdok_disshab_0000001067-d1135188e59gnd:1016003706Prof. Dr. med. Stephan SchaeferProf. Dr. med. Stephan Schaeferrosdok_disshab_0000001067-d1135188e74gnd:132475170Prof. Dr. rer. nat. Hubert BahlProf. Dr. rer. nat. Hubert Bahlrosdok_disshab_0000001067-d1135188e89gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnProf. Dr. med. Stephan SchaeferProf. Dr. rer. nat. Hubert BahlUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnProf. Dr. med. Stephan SchaeferProf. Dr. rer. nat. Hubert BahlUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLijo JohnRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001246http://purl.uni-rostock.de/rosdok/id00001246urn:nbn:de:gbv:28-diss2013-0159-8microarrayNS4Bhost factors hepatitis E virusORF2ER stressanti-apoptotic heat schock proteinsInvestigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified oncogenic pathway. For hepatitis E virus, I looked for the cellular effects conferred by the capsid protein ORF2, and the results showed that ORF2 induced activation of CHOP did not lead to apoptosis which might be due to the up regulation of anti-apoptotic chaperones like Hsp72.20132013[xslt]Saxonrosdok/id00001246https://purl.uni-rostock.de/rosdok/id0000124677257148110.18453/rosdok_id00001246urn:nbn:de:gbv:28-diss2013-0159-8Lijo JohnJohn LijoIdentification of host cellular requirements for positive strand RNA viruses : Hepatitis C virus and hepatitis E virusDissertationdoctoral thesisUniversität Rostock, 2013Investigation of the host cellular requirements of two positive strand RNA viruses, by microarray, phospho-proteome array and by siRNA screening identified differential expression of host genes during hepatitis C virus viral entry. Also my studies suggest that NS4B regulates a newly identified…Lijo JohnIdentification of host cellular requirements for positive strand RNA virusesHepatitis C virus and hepatitis E virusUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001246LijoJohn1979-VerfasserInaut1016003706Prof. Dr. med.StephanSchaeferUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs132475170Prof. Dr. rer. nat.HubertBahlUniversität Rostock, Institut für Medizinische Mikrobiologie, Virologie und HygieneAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001246[purl]http://purl.uni-rostock.de/rosdok/id00001246[urn]urn:nbn:de:gbv:28-diss2013-0159-8open_access20132013epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published