mycoreobjectrosdok_disshab_0000001109rosdok_disshab_0000001109rosdokdisshabrosdok_derivate_00000052302023-08-08T10:04:39.245Z2014-01-31T10:56:56.193Zadministratorpublished1rosdok_derivate_0000005230truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001288778072312MODS updated during RosDok migration in June 2021DissertationHochschulschrift1030279799AchimSalamon1979-VerfasserInautThe Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitroen109199960Prof. Dr. rer. nat.Dieter G.WeissUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsPD Dr. rer. nat. et med. habil.KirstenPetersUniversitätsmedizin Rostock, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001288http://purl.uni-rostock.de/rosdok/id00001288urn:nbn:de:gbv:28-diss2014-0040-8570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20122014Universitätsbibliothek RostockRostock20142014Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.TNFMSCASCUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001288doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/The Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In VitroThe Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitrognd:1030279799gnd:109199960gnd:2147083-2gnd:1030279799gnd:109199960gnd:2147083-2rosdok_disshab_0000001109-d1470560e39gnd:1030279799Achim SalamonAchim Salamonrosdok_disshab_0000001109-d1470560e60gnd:109199960Prof. Dr. rer. nat. Dieter G. WeissProf. Dr. rer. nat. Dieter G. Weissrosdok_disshab_0000001109-d1470560e75PD Dr. rer. nat. et med. habil. Kirsten PetersPD Dr. rer. nat. et med. habil. Kirsten Petersrosdok_disshab_0000001109-d1470560e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonProf. Dr. rer. nat. Dieter G. WeissPD Dr. rer. nat. et med. habil. Kirsten PetersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonProf. Dr. rer. nat. Dieter G. WeissPD Dr. rer. nat. et med. habil. Kirsten PetersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001288http://purl.uni-rostock.de/rosdok/id00001288urn:nbn:de:gbv:28-diss2014-0040-8TNFMSCASCChronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.20142014epub.dissertation1 Dissertation_Salamon_2014.pdf 53471268 7a1a50b8d9c01469ff509d0249aa52c4 rosdok/id00001288778072312MODS updated during RosDok migration in June 2021DissertationHochschulschrift1030279799AchimSalamon1979-VerfasserInautThe Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In Vitroen109199960Prof. Dr. rer. nat.Dieter G.WeissUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsPD Dr. rer. nat. et med. habil.KirstenPetersUniversitätsmedizin Rostock, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001288http://purl.uni-rostock.de/rosdok/id00001288urn:nbn:de:gbv:28-diss2014-0040-8570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20122014Universitätsbibliothek RostockRostock20142014Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. 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Dieter G. WeissProf. Dr. rer. nat. Dieter G. Weissrosdok_disshab_0000001109-d1470560e75PD Dr. rer. nat. et med. habil. Kirsten PetersPD Dr. rer. nat. et med. habil. Kirsten Petersrosdok_disshab_0000001109-d1470560e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonProf. Dr. rer. nat. Dieter G. WeissPD Dr. rer. nat. et med. habil. Kirsten PetersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonProf. Dr. rer. nat. Dieter G. WeissPD Dr. rer. nat. et med. habil. Kirsten PetersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAchim SalamonRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001288http://purl.uni-rostock.de/rosdok/id00001288urn:nbn:de:gbv:28-diss2014-0040-8TNFMSCASCChronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.20142014[xslt]Saxonrosdok/id00001288https://purl.uni-rostock.de/rosdok/id0000128877807231210.18453/rosdok_id00001288urn:nbn:de:gbv:28-diss2014-0040-8Achim SalamonSalamon AchimThe Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In VitroDissertationdoctoral thesisUniversität Rostock, 2014Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone…Achim SalamonThe Impact of Tumor Necrosis Factor on Osteogenic Differentiation of Human Adipose Tissue-Derived Stem Cells In VitroUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000012881030279799AchimSalamon1979-VerfasserInaut109199960Prof. Dr. rer. nat.Dieter G.WeissUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsPD Dr. rer. nat. et med. habil.KirstenPetersUniversitätsmedizin Rostock, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001288[purl]http://purl.uni-rostock.de/rosdok/id00001288[urn]urn:nbn:de:gbv:28-diss2014-0040-8open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published