10.18453/rosdok_id00001288 Salamon, Achim Achim Salamon http://d-nb.info/gnd/1030279799 Universität Rostock 2014 570 Life science 2014 en http://purl.uni-rostock.de/rosdok/id00001288 urn:nbn:de:gbv:28-diss2014-0040-8 Chronic inflammatory diseases are characterized by elevated levels of tumor necrosis factor (TNF) and decreasing bone mineral density. TNF promotes differentiation of bone resorbing osteoclasts from their hematopoietic precursors. Its impact on differentiation of mesenchymal precursors of bone forming osteoblasts isolated from adipose (ASC) was largely unknown. I found that TNF did neither induce osteoblastic differentiation of ASC nor exhibited an impact on osteoblastic differentiation in vitro. Thus, TNF mediates osteolysis in vivo presumably mainly by its pro-osteoclastogenic effect.