mycoreobjectrosdok_disshab_0000001124rosdok_disshab_0000001124rosdokdisshabrosdok_derivate_00000052412023-08-08T10:04:42.719Z2014-02-18T11:20:33.288Zadministratorpublished1rosdok_derivate_0000005241truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001303779622480MODS updated during RosDok migration in June 2021DissertationHochschulschrift1047564882YvonneSchmitz1980-VerfasserInautCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsen133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Systembiologie und Bioinformatik, Institut für InformatikAkademischeR BetreuerIndgs136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniversität Rostock, Modellierung und Simulation, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.Helen M.ByrneUniversity of Oxford, Computational Biology, Mathematical InstituteAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001303http://purl.uni-rostock.de/rosdok/id00001303urn:nbn:de:gbv:28-diss2014-0055-2000 Allgemeines, Wissenschaft500 NaturwissenschaftenFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20132014Universitätsbibliothek RostockRostock20142014The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.Wnt pathwayintracellular transportdestruction complexretentionsteady state analysissensitivity analysisUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001303doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:000SDNB:000000 Allgemeines, Wissenschaft000 Generalities, ScienceSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Compartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsgnd:1047564882gnd:133515931gnd:136258794gnd:10085032-7gnd:1047564882gnd:133515931gnd:136258794gnd:10085032-7rosdok_disshab_0000001124-d415910e39gnd:1047564882Yvonne SchmitzYvonne Schmitzrosdok_disshab_0000001124-d415910e61gnd:133515931Prof. Dr. Olaf WolkenhauerProf. Dr. Olaf Wolkenhauerrosdok_disshab_0000001124-d415910e76gnd:136258794Prof. Dr. rer. nat. habil. 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ByrneUniversität Rostock Fakultät für Informatik und ElektrotechnikYvonne SchmitzRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001303http://purl.uni-rostock.de/rosdok/id00001303urn:nbn:de:gbv:28-diss2014-0055-2Wnt pathwayintracellular transportdestruction complexretentionsteady state analysissensitivity analysisThe Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.20142014epub.dissertation1 Dissertation_Schmitz_2014.pdf 9799205 8225aac90d1474119758855995436186 rosdok/id00001303779622480MODS updated during RosDok migration in June 2021DissertationHochschulschrift1047564882YvonneSchmitz1980-VerfasserInautCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsen133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Systembiologie und Bioinformatik, Institut für InformatikAkademischeR BetreuerIndgs136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniversität Rostock, Modellierung und Simulation, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.Helen M.ByrneUniversity of Oxford, Computational Biology, Mathematical InstituteAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001303http://purl.uni-rostock.de/rosdok/id00001303urn:nbn:de:gbv:28-diss2014-0055-2000 Allgemeines, Wissenschaft500 NaturwissenschaftenFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20132014Universitätsbibliothek RostockRostock20142014The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.Wnt pathwayintracellular transportdestruction complexretentionsteady state analysissensitivity analysisUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001303 2014-02-18T11:20:33.288Z 2023-08-08T10:04:42.719Z 2023-08-18T10:04:42.724Z {"identifier":"rosdok/id00001303","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:07:43.808Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001303","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:07:44.025Z","registered":"2018-06-30T13:07:44.025Z"} {"identifier":"10.18453/rosdok_id00001303","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:07:45.514Z","registered":"2018-06-30T13:07:45.514Z"} {"identifier":"urn:nbn:de:gbv:28-diss2014-0055-2","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:07:43.813Z","registered":"2014-03-01T03:02:45.403Z"} administratorfulltextfile/rosdok_disshab_0000001124/rosdok_derivate_0000005241/Dissertation_Schmitz_2014.pdfCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsgnd:1047564882gnd:133515931gnd:136258794gnd:10085032-7gnd:1047564882gnd:133515931gnd:136258794gnd:10085032-7rosdok_disshab_0000001124-d415910e39gnd:1047564882Yvonne SchmitzYvonne Schmitzrosdok_disshab_0000001124-d415910e61gnd:133515931Prof. Dr. Olaf WolkenhauerProf. Dr. Olaf Wolkenhauerrosdok_disshab_0000001124-d415910e76gnd:136258794Prof. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. rer. nat. habil. Adelinde M. Uhrmacherrosdok_disshab_0000001124-d415910e91Prof. Dr. Helen M. ByrneProf. Dr. Helen M. Byrnerosdok_disshab_0000001124-d415910e105gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikYvonne SchmitzProf. Dr. Olaf WolkenhauerProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Helen M. ByrneUniversität Rostock Fakultät für Informatik und ElektrotechnikYvonne SchmitzProf. Dr. Olaf WolkenhauerProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Helen M. ByrneUniversität Rostock Fakultät für Informatik und ElektrotechnikYvonne SchmitzRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001303http://purl.uni-rostock.de/rosdok/id00001303urn:nbn:de:gbv:28-diss2014-0055-2Wnt pathwayintracellular transportdestruction complexretentionsteady state analysissensitivity analysisThe Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3. Based on experimental findings, I develop and investigate compartmental models in order to analyse of the role of nucleo-cytoplasmic shuttling of these proteins in Wnt signalling. I show that the compartmental separation of b-cat and its antagonists yields an increase of the b-cat/TCF concentration.20142014[xslt]Saxonrosdok/id00001303https://purl.uni-rostock.de/rosdok/id0000130377962248010.18453/rosdok_id00001303urn:nbn:de:gbv:28-diss2014-0055-2Yvonne SchmitzSchmitz YvonneCompartmental modelling of the Wnt pathway : Elucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsDissertationdoctoral thesisUniversität Rostock, 2014The Wnt pathway plays a critical role in development and disease. The key player of the pathway is b-cat. In the nucleus, the complex formation of b-cat and TCF initiates target gene expression. Its activity is mainly regulated by retention and degradation by its antagonists APC, Axin and GSK3.…Yvonne SchmitzCompartmental modelling of the Wnt pathwayElucidating the role of nucleo-cytoplasmic shuttling of beta-catenin and its antagonistsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000013031047564882YvonneSchmitz1980-VerfasserInaut133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Systembiologie und Bioinformatik, Institut für InformatikAkademischeR BetreuerIndgs136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniversität Rostock, Modellierung und Simulation, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.Helen M.ByrneUniversity of Oxford, Computational Biology, Mathematical InstituteAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001303[purl]http://purl.uni-rostock.de/rosdok/id00001303[urn]urn:nbn:de:gbv:28-diss2014-0055-2open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:000SDNB:500institution:unirostock.iefstate:published