Role of HCN Channels in Regulation of Synaptic Plasticity at Early Postnatal Medial Perforant Path

10.18453/rosdok_id00001312 Badel, Gulshat Gulshat Badel http://d-nb.info/gnd/1048733793 Role of HCN Channels in Regulation of Synaptic Plasticity at Early Postnatal Medial Perforant Path Die Rolle der HCN-Kanäle bei der Regulation der synaptischen Plastizität des postnatalen medialen Tractus perforans Universität Rostock 2014 610 Medical sciences Medicine 2014 en http://purl.uni-rostock.de/rosdok/id00001312 urn:nbn:de:gbv:28-diss2014-0064-2 HCN channel blocker ZD7288 depressed synaptic transmission at medial perforant path (MPP) synapses. Low-frequency stimulation (LFS) delivered to these fibers resulted in enhanced LTD after ZD7288 in P9-15 rats, but not in P30-60 rats. Hence, HCN channel activation during neuronal activity may compromise the propensity of LTD at these synapses. Results obtained with L-NAME iterated the effect of HCN channel inhibition on LTD, suggesting that retrograde signaling with NO might play a major role in the linkage between postsynaptic NMDAR activation and presynaptic HCN channel function.