10.18453/rosdok_id00001323
Lao, Angelyn
Angelyn
Lao
http://d-nb.info/gnd/1032452056
A systems biology approach to understand the influence of SORLA on amyloidogenic processing in Alzheimer's disease
Ein systembiologischer Ansatz zum Verständnis der Wirkung von SORLA auf die Amyloid-Prozessierung bei Alzheimer
Universität Rostock
2014
510 Mathematics
570 Life science
2014
en
http://purl.uni-rostock.de/rosdok/id00001323
urn:nbn:de:gbv:28-diss2014-0075-4
In this dissertation APP processing is modelled and the influence of SORLA in Alzheimer’s disease is evaluated. A model with both monomeric and dimeric APP in a single compartment best fitted the experimental data suggesting that SORLA prevents APP oligomerization and affects β-secretase indirectly. Including compartmental details into the combined model, the multi-compartmental model determines the relative contribution of SORLA to each APP-cleavage step showing that SORLA specifically impairs the processing of APP dimer and alters the dynamical behavior of beta-secretase.