10.18453/rosdok_id00001325
Lai, Xin
Xin
Lai
http://d-nb.info/gnd/1034831569
A systems biology approach to unravel the cellular function of microRNAs
Ein systembiologischer Ansatz zur Charakterisierung der zellulären Funktion von microRNAs
Universität Rostock
2014
000 Generalities, Science
570 Life science
2014
en
http://purl.uni-rostock.de/rosdok/id00001325
urn:nbn:de:gbv:28-diss2014-0077-5
The systems biology approach, combining biological data with mathematical modelling, provides the means to elucidate the role of miRNAs in signalling pathways and gene regulatory networks. The approach is characterised by a cyclic process, including biological network construction, mathematical modelling, simulation and experimental validation. Using this approach, I first investigate the regulatory role of miR-34a in a signalling pathway. Second, the investigation of the regulation of a miRNA target hub by multiple and cooperative miRNAs is presented.