mycoreobjectrosdok_disshab_0000001170rosdok_disshab_0000001170rosdokdisshabrosdok_derivate_00000148882023-08-08T10:04:57.101Z2014-07-31T08:58:33.958ZadministratoreditorDpublished1rosdok_derivate_0000014888truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001349793013402MODS updated during RosDok migration in June 2021DissertationHochschulschrift1054106657JijuMani1981-VerfasserInautCD8+ T cell epitopes derived from the polyomavirus capsid protein VP1enProf. Dr. med.MichaelSchmittUniversitätsklinikum Heidelberg, Medizinische Klinik VAkademischeR BetreuerIndgsapl. Prof. Dr. rer. nat. habil.UlrikeGimsaLeibniz-Institut für Nutztierbiologie, Institut für VerhaltensphysiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001349http://purl.uni-rostock.de/rosdok/id00001349urn:nbn:de:gbv:28-diss2014-0101-6570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.JCVBKVImmunotherapyUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001349doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/CD8+ T cell epitopes derived from the polyomavirus capsid protein VP1CD8+ T cell epitopes derived from the polyomavirus capsid protein VP1gnd:1054106657gnd:2147083-2gnd:1054106657gnd:2147083-2rosdok_disshab_0000001170-d2225486e39gnd:1054106657Jiju ManiJiju Manirosdok_disshab_0000001170-d2225486e60Prof. Dr. med. Michael SchmittProf. Dr. med. Michael Schmittrosdok_disshab_0000001170-d2225486e73apl. Prof. Dr. rer. nat. habil. Ulrike Gimsaapl. Prof. Dr. rer. nat. habil. Ulrike Gimsarosdok_disshab_0000001170-d2225486e86gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiProf. Dr. med. Michael Schmittapl. Prof. Dr. rer. nat. habil. Ulrike GimsaUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiProf. Dr. med. Michael Schmittapl. Prof. Dr. rer. nat. habil. Ulrike GimsaUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001349http://purl.uni-rostock.de/rosdok/id00001349urn:nbn:de:gbv:28-diss2014-0101-6JCVBKVImmunotherapyOne method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.20142014epub.dissertation1 Dissertation_Mani_2014.pdf 13259299 da7fb74985d7daea4f01520eb2794c64 rosdok/id00001349793013402MODS updated during RosDok migration in June 2021DissertationHochschulschrift1054106657JijuMani1981-VerfasserInautCD8+ T cell epitopes derived from the polyomavirus capsid protein VP1enProf. Dr. med.MichaelSchmittUniversitätsklinikum Heidelberg, Medizinische Klinik VAkademischeR BetreuerIndgsapl. Prof. Dr. rer. nat. habil.UlrikeGimsaLeibniz-Institut für Nutztierbiologie, Institut für VerhaltensphysiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001349http://purl.uni-rostock.de/rosdok/id00001349urn:nbn:de:gbv:28-diss2014-0101-6570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.JCVBKVImmunotherapyUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001349 2014-07-31T08:58:33.958Z 2023-08-08T10:04:57.101Z 2023-08-18T10:04:57.106Z editorD {"identifier":"rosdok/id00001349","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:09:25.574Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001349","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:09:25.765Z","registered":"2018-06-30T13:09:25.765Z"} {"identifier":"10.18453/rosdok_id00001349","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:09:27.059Z","registered":"2018-06-30T13:09:27.059Z"} {"identifier":"urn:nbn:de:gbv:28-diss2014-0101-6","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:09:25.580Z","registered":"2014-08-20T02:21:21.110Z"} administratorfulltextfile/rosdok_disshab_0000001170/rosdok_derivate_0000014888/Dissertation_Mani_2014.pdfCD8+ T cell epitopes derived from the polyomavirus capsid protein VP1CD8+ T cell epitopes derived from the polyomavirus capsid protein VP1gnd:1054106657gnd:2147083-2gnd:1054106657gnd:2147083-2rosdok_disshab_0000001170-d2225486e39gnd:1054106657Jiju ManiJiju Manirosdok_disshab_0000001170-d2225486e60Prof. Dr. med. Michael SchmittProf. Dr. med. Michael Schmittrosdok_disshab_0000001170-d2225486e73apl. Prof. Dr. rer. nat. habil. Ulrike Gimsaapl. Prof. Dr. rer. nat. habil. Ulrike Gimsarosdok_disshab_0000001170-d2225486e86gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiProf. Dr. med. Michael Schmittapl. Prof. Dr. rer. nat. habil. Ulrike GimsaUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiProf. Dr. med. Michael Schmittapl. Prof. Dr. rer. nat. habil. Ulrike GimsaUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätJiju ManiRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001349http://purl.uni-rostock.de/rosdok/id00001349urn:nbn:de:gbv:28-diss2014-0101-6JCVBKVImmunotherapyOne method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and high functional reactivity in long-term cultures. Additionally, novel, naturally processed JCV-VP1-derived CD8+ T cell epitopes were identified. These new data contribute to the development of therapies that, due to their cross-reactivity, target both polyomaviruses-related diseases simultaneously.20142014[xslt]Saxonrosdok/id00001349https://purl.uni-rostock.de/rosdok/id0000134979301340210.18453/rosdok_id00001349urn:nbn:de:gbv:28-diss2014-0101-6Jiju ManiMani JijuCD8+ T cell epitopes derived from the polyomavirus capsid protein VP1Dissertationdoctoral thesisUniversität Rostock, 2014One method for treatment of JCV and BKV-related diseases is by adoptive transfer of virus-specific T-cells. Precursor frequency of JCV-capsid protein VP1-specific T-cells was very low compared to other viruses. Optimized assays revealed JCV-specific T cells with high avidity, peptide-specificity and…Jiju ManiCD8+ T cell epitopes derived from the polyomavirus capsid protein VP1Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000013491054106657JijuMani1981-VerfasserInautProf. Dr. med.MichaelSchmittUniversitätsklinikum Heidelberg, Medizinische Klinik VAkademischeR BetreuerIndgsapl. Prof. Dr. rer. nat. habil.UlrikeGimsaLeibniz-Institut für Nutztierbiologie, Institut für VerhaltensphysiologieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001349[purl]http://purl.uni-rostock.de/rosdok/id00001349[urn]urn:nbn:de:gbv:28-diss2014-0101-6open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published