mycoreobjectrosdok_disshab_0000001171rosdok_disshab_0000001171rosdokdisshabrosdok_derivate_00000127282023-08-08T10:04:57.352Z2014-07-31T09:01:48.993ZadministratoreditorDpublished1rosdok_derivate_0000012728truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001350791606627MODS updated during RosDok migration in June 2021DissertationHochschulschrift1054016976LindaSupe1983-VerfasserInautDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsenProf. Dr.BerndSchmidtUniversität Potsdam, Institut für ChemieAkademischeR BetreuerIndgsProf. Dr.JensChristoffersCarl von Ossietzky Universität Oldenburg, Institut für Reine und Angewandte ChemieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001350http://purl.uni-rostock.de/rosdok/id00001350urn:nbn:de:gbv:28-diss2014-0102-2540 ChemieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.DeazapurinesCyclocondensationFluorineUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001350doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:540SDNB:540540 Chemie540 Chemistry & allied sciencesinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Design and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsgnd:1054016976gnd:2147083-2gnd:1054016976gnd:2147083-2rosdok_disshab_0000001171-d1006009e39gnd:1054016976Linda SupeLinda Superosdok_disshab_0000001171-d1006009e61Prof. Dr. Bernd SchmidtProf. Dr. Bernd Schmidtrosdok_disshab_0000001171-d1006009e74Prof. Dr. Jens ChristoffersProf. Dr. Jens Christoffersrosdok_disshab_0000001171-d1006009e87gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeProf. Dr. Bernd SchmidtProf. Dr. Jens ChristoffersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeProf. Dr. Bernd SchmidtProf. Dr. Jens ChristoffersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001350http://purl.uni-rostock.de/rosdok/id00001350urn:nbn:de:gbv:28-diss2014-0102-2DeazapurinesCyclocondensationFluorineThe work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.20142014epub.dissertation1 Dissertation_Supe_2014.pdf 2932964 7dd8c15a021060d54ef831c957284da7 rosdok/id00001350791606627MODS updated during RosDok migration in June 2021DissertationHochschulschrift1054016976LindaSupe1983-VerfasserInautDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsenProf. Dr.BerndSchmidtUniversität Potsdam, Institut für ChemieAkademischeR BetreuerIndgsProf. Dr.JensChristoffersCarl von Ossietzky Universität Oldenburg, Institut für Reine und Angewandte ChemieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001350http://purl.uni-rostock.de/rosdok/id00001350urn:nbn:de:gbv:28-diss2014-0102-2540 ChemieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.DeazapurinesCyclocondensationFluorineUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001350 2014-07-31T09:01:48.993Z 2023-08-08T10:04:57.352Z 2023-08-18T10:04:57.357Z editorD {"identifier":"rosdok/id00001350","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:09:27.651Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001350","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:09:27.840Z","registered":"2018-06-30T13:09:27.840Z"} {"identifier":"10.18453/rosdok_id00001350","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:09:29.172Z","registered":"2018-06-30T13:09:29.172Z"} {"identifier":"urn:nbn:de:gbv:28-diss2014-0102-2","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:09:27.657Z","registered":"2014-08-02T02:23:19.660Z"} administratorfulltextfile/rosdok_disshab_0000001171/rosdok_derivate_0000012728/Dissertation_Supe_2014.pdfDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsgnd:1054016976gnd:2147083-2gnd:1054016976gnd:2147083-2rosdok_disshab_0000001171-d1006009e39gnd:1054016976Linda SupeLinda Superosdok_disshab_0000001171-d1006009e61Prof. Dr. Bernd SchmidtProf. Dr. Bernd Schmidtrosdok_disshab_0000001171-d1006009e74Prof. Dr. Jens ChristoffersProf. Dr. Jens Christoffersrosdok_disshab_0000001171-d1006009e87gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeProf. Dr. Bernd SchmidtProf. Dr. Jens ChristoffersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeProf. Dr. Bernd SchmidtProf. Dr. Jens ChristoffersUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätLinda SupeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001350http://purl.uni-rostock.de/rosdok/id00001350urn:nbn:de:gbv:28-diss2014-0102-2DeazapurinesCyclocondensationFluorineThe work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and bielectrophiles, inverse electron-demand Diels-Alder reaction, palladium-catalyzed C-C coupling reaction. N-nucleosides of purine analogues were synthesized using modified silyl Hilbert-Jones method. Scope and limitations of hydrogenation of pyridine ring of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones were studied.20142014[xslt]Saxonrosdok/id00001350https://purl.uni-rostock.de/rosdok/id0000135079160662710.18453/rosdok_id00001350urn:nbn:de:gbv:28-diss2014-0102-2Linda SupeSupe LindaDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosides : New purine isosters as potential drug-like scaffoldsDissertationdoctoral thesisUniversität Rostock, 2014The work is devoted to study synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones with potential biological activity. 1H-pyrazolo[3,4-b]pyridin-3(2H)-one derived moieties were afforded using classical approaches involving [3+3] cyclocondensation of enamine fragment-containing heterocycle and…Linda SupeDesign and synthesis of 1H-pyrazolo[3,4-b]pyridin-3(2H)-ones and corresponding N-nucleosidesNew purine isosters as potential drug-like scaffoldsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000013501054016976LindaSupe1983-VerfasserInautProf. Dr.BerndSchmidtUniversität Potsdam, Institut für ChemieAkademischeR BetreuerIndgsProf. Dr.JensChristoffersCarl von Ossietzky Universität Oldenburg, Institut für Reine und Angewandte ChemieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001350[purl]http://purl.uni-rostock.de/rosdok/id00001350[urn]urn:nbn:de:gbv:28-diss2014-0102-2open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:540institution:unirostock.mnfstate:published