mycoreobjectrosdok_disshab_0000001205rosdok_disshab_0000001205rosdokdisshabrosdok_derivate_00000149242023-08-08T10:05:08.227Z2014-09-03T09:06:34.142ZadministratoreditorDpublished1rosdok_derivate_0000014924truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001384796438269MODS updated during RosDok migration in June 2021DissertationHochschulschrift1057858102SonjaStrunz1981-VerfasserInautTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersen133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Lehrstuhl für Systembiologie und Bioinformatik, Institut für Informatik und ElektrotechnikAkademischeR BetreuerIndgsDr.RalfKriehuberForschungszentrum Jülich, GB Sicherheit und Strahlenschutz, S-US StrahlenbiologieAkademischeR BetreuerIndgsProf. Dr.MarioStankeUniversität Greifswald, Lehrstuhl für Bioinformatik, Institut für Mathematik und InformatikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001384http://purl.uni-rostock.de/rosdok/id00001384urn:nbn:de:gbv:28-diss2014-0136-2000 Allgemeines, Wissenschaft570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.biodosimetryIonizing radiationgene expression analysissupervised classificationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001384doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:000SDNB:000000 Allgemeines, Wissenschaft000 Generalities, ScienceSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Transcriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersgnd:1057858102gnd:133515931gnd:10085032-7gnd:1057858102gnd:133515931gnd:10085032-7rosdok_disshab_0000001205-d522158e39gnd:1057858102Sonja StrunzSonja Strunzrosdok_disshab_0000001205-d522158e60gnd:133515931Prof. Dr. Olaf WolkenhauerProf. Dr. Olaf Wolkenhauerrosdok_disshab_0000001205-d522158e75Dr. Ralf KriehuberDr. Ralf Kriehuberrosdok_disshab_0000001205-d522158e88Prof. Dr. Mario StankeProf. Dr. Mario Stankerosdok_disshab_0000001205-d522158e102gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzProf. Dr. Olaf WolkenhauerDr. Ralf KriehuberProf. Dr. Mario StankeUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzProf. Dr. Olaf WolkenhauerDr. Ralf KriehuberProf. Dr. Mario StankeUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001384http://purl.uni-rostock.de/rosdok/id00001384urn:nbn:de:gbv:28-diss2014-0136-2biodosimetryIonizing radiationgene expression analysissupervised classificationThe development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.20142014epub.dissertation1 Dissertation_Strunz_2014.pdf 7078454 68dd088038414f39469136a579276344 rosdok/id00001384796438269MODS updated during RosDok migration in June 2021DissertationHochschulschrift1057858102SonjaStrunz1981-VerfasserInautTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersen133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Lehrstuhl für Systembiologie und Bioinformatik, Institut für Informatik und ElektrotechnikAkademischeR BetreuerIndgsDr.RalfKriehuberForschungszentrum Jülich, GB Sicherheit und Strahlenschutz, S-US StrahlenbiologieAkademischeR BetreuerIndgsProf. Dr.MarioStankeUniversität Greifswald, Lehrstuhl für Bioinformatik, Institut für Mathematik und InformatikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001384http://purl.uni-rostock.de/rosdok/id00001384urn:nbn:de:gbv:28-diss2014-0136-2000 Allgemeines, Wissenschaft570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.biodosimetryIonizing radiationgene expression analysissupervised classificationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001384 2014-09-03T09:06:34.142Z 2023-08-08T10:05:08.227Z 2023-08-18T10:05:08.232Z editorD {"identifier":"rosdok/id00001384","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:10:40.755Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001384","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:10:40.934Z","registered":"2018-06-30T13:10:40.934Z"} {"identifier":"10.18453/rosdok_id00001384","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:10:42.336Z","registered":"2018-06-30T13:10:42.336Z"} {"identifier":"urn:nbn:de:gbv:28-diss2014-0136-2","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:10:40.761Z","registered":"2014-09-10T02:17:39.713Z"} administratorfulltextfile/rosdok_disshab_0000001205/rosdok_derivate_0000014924/Dissertation_Strunz_2014.pdfTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersgnd:1057858102gnd:133515931gnd:10085032-7gnd:1057858102gnd:133515931gnd:10085032-7rosdok_disshab_0000001205-d522158e39gnd:1057858102Sonja StrunzSonja Strunzrosdok_disshab_0000001205-d522158e60gnd:133515931Prof. Dr. Olaf WolkenhauerProf. Dr. Olaf Wolkenhauerrosdok_disshab_0000001205-d522158e75Dr. Ralf KriehuberDr. Ralf Kriehuberrosdok_disshab_0000001205-d522158e88Prof. Dr. Mario StankeProf. Dr. Mario Stankerosdok_disshab_0000001205-d522158e102gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzProf. Dr. Olaf WolkenhauerDr. Ralf KriehuberProf. Dr. Mario StankeUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzProf. Dr. Olaf WolkenhauerDr. Ralf KriehuberProf. Dr. Mario StankeUniversität Rostock Fakultät für Informatik und ElektrotechnikSonja StrunzRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001384http://purl.uni-rostock.de/rosdok/id00001384urn:nbn:de:gbv:28-diss2014-0136-2biodosimetryIonizing radiationgene expression analysissupervised classificationThe development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.20142014[xslt]Saxonrosdok/id00001384https://purl.uni-rostock.de/rosdok/id0000138479643826910.18453/rosdok_id00001384urn:nbn:de:gbv:28-diss2014-0136-2Sonja StrunzStrunz SonjaTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersDissertationdoctoral thesisUniversität Rostock, 2014The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which…Sonja StrunzTranscriptional responses to radiation exposure facilitate the discovery of biomarkers functioning as radiation biodosimetersUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000013841057858102SonjaStrunz1981-VerfasserInaut133515931Prof. Dr.OlafWolkenhauerUniversität Rostock, Lehrstuhl für Systembiologie und Bioinformatik, Institut für Informatik und ElektrotechnikAkademischeR BetreuerIndgsDr.RalfKriehuberForschungszentrum Jülich, GB Sicherheit und Strahlenschutz, S-US StrahlenbiologieAkademischeR BetreuerIndgsProf. Dr.MarioStankeUniversität Greifswald, Lehrstuhl für Bioinformatik, Institut für Mathematik und InformatikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001384[purl]http://purl.uni-rostock.de/rosdok/id00001384[urn]urn:nbn:de:gbv:28-diss2014-0136-2open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:000SDNB:570institution:unirostock.iefstate:published