10.18453/rosdok_id00001384 Strunz, Sonja Sonja Strunz http://d-nb.info/gnd/1057858102 Universität Rostock 2014 000 Generalities, Science 570 Life science 2014 en http://purl.uni-rostock.de/rosdok/id00001384 urn:nbn:de:gbv:28-diss2014-0136-2 The development of new methods for a retrospective quantification of the radiation dose of exposed individuals is of widespread interest. To this end, I developed a computational framework for biomarker discovery and radiation dose prediction and successfully identified gene signatures with which low and medium to high radiation doses can be accurately quantified. To enhance our understanding of the radiation-induced transcriptional response, I additionally analyzed microarray data of human PBLs after ex vivo gamma-irradiation and characterized affected functional processes and pathways.