mycoreobjectrosdok_disshab_0000001243rosdok_disshab_0000001243rosdokdisshabrosdok_derivate_00000190402023-08-08T10:05:20.347Z2014-11-11T13:30:46.738ZadministratoreditorDpublished1rosdok_derivate_0000019040truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001422805590951MODS updated during RosDok migration in June 2021DissertationHochschulschrift1060187329TareqSalem1970-VerfasserInautGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal canceren113623496Prof. Dr. medFriedrichPrallUniversität Rostock, Institut für PathologieAkademischeR BetreuerIndgs1028873808PD Dr. rer. nat.MichaelLinnebacherUniversität Rostock, Klinik und Poliklinik für ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.MathiasEvertUniversität Greifswald, Institut für PathologieAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001422http://purl.uni-rostock.de/rosdok/id00001422urn:nbn:de:gbv:28-diss2014-0174-3610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.tumur Xeno-grafts/primary tumour cell linesPTEN expressiontumour suppressor gene inactivationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001422doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. 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Mathias EvertUniversität Rostock UniversitätsmedizinTareq SalemRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001422http://purl.uni-rostock.de/rosdok/id00001422urn:nbn:de:gbv:28-diss2014-0174-3tumur Xeno-grafts/primary tumour cell linesPTEN expressiontumour suppressor gene inactivationThis study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.20142014epub.dissertation1 Dissertation_Salem_2014.pdf 2506283 d813cff9294c0347df7555a16f9de895 rosdok/id00001422805590951MODS updated during RosDok migration in June 2021DissertationHochschulschrift1060187329TareqSalem1970-VerfasserInautGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal canceren113623496Prof. Dr. medFriedrichPrallUniversität Rostock, Institut für PathologieAkademischeR BetreuerIndgs1028873808PD Dr. rer. nat.MichaelLinnebacherUniversität Rostock, Klinik und Poliklinik für ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.MathiasEvertUniversität Greifswald, Institut für PathologieAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001422http://purl.uni-rostock.de/rosdok/id00001422urn:nbn:de:gbv:28-diss2014-0174-3610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2014monographic20142014Universitätsbibliothek RostockRostock20142014This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.tumur Xeno-grafts/primary tumour cell linesPTEN expressiontumour suppressor gene inactivationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001422 2014-11-11T13:30:46.738Z 2023-08-08T10:05:20.347Z 2023-08-18T10:05:20.352Z editorD {"identifier":"rosdok/id00001422","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:12:05.395Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001422","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:12:05.588Z","registered":"2018-06-30T13:12:05.588Z"} {"identifier":"10.18453/rosdok_id00001422","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:12:06.881Z","registered":"2018-06-30T13:12:06.881Z"} {"identifier":"urn:nbn:de:gbv:28-diss2014-0174-3","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:12:05.401Z","registered":"2014-11-27T03:09:29.020Z"} administratorfulltextfile/rosdok_disshab_0000001243/rosdok_derivate_0000019040/Dissertation_Salem_2014.pdfGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancerGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancergnd:1060187329gnd:113623496gnd:1028873808gnd:1029510660gnd:1060187329gnd:113623496gnd:1028873808gnd:1029510660rosdok_disshab_0000001243-d893326e39gnd:1060187329Tareq SalemTareq Salemrosdok_disshab_0000001243-d893326e60gnd:113623496Prof. Dr. med Friedrich PrallProf. Dr. med Friedrich Prallrosdok_disshab_0000001243-d893326e75gnd:1028873808PD Dr. rer. nat. Michael LinnebacherPD Dr. rer. nat. Michael Linnebacherrosdok_disshab_0000001243-d893326e90Prof. Dr. med. Mathias EvertProf. Dr. med. Mathias Evertrosdok_disshab_0000001243-d893326e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinTareq SalemProf. Dr. med Friedrich PrallPD Dr. rer. nat. Michael LinnebacherProf. Dr. med. Mathias EvertUniversität Rostock UniversitätsmedizinTareq SalemProf. Dr. med Friedrich PrallPD Dr. rer. nat. Michael LinnebacherProf. Dr. med. Mathias EvertUniversität Rostock UniversitätsmedizinTareq SalemRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001422http://purl.uni-rostock.de/rosdok/id00001422urn:nbn:de:gbv:28-diss2014-0174-3tumur Xeno-grafts/primary tumour cell linesPTEN expressiontumour suppressor gene inactivationThis study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.20142014[xslt]Saxonrosdok/id00001422https://purl.uni-rostock.de/rosdok/id0000142280559095110.18453/rosdok_id00001422urn:nbn:de:gbv:28-diss2014-0174-3Tareq SalemSalem TareqGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancerDissertationdoctoral thesisUniversität Rostock, 2014This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene…Tareq SalemGene mutations and losses of heterozygosity of TP53 and PTEN in colorectal cancerUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000014221060187329TareqSalem1970-VerfasserInaut113623496Prof. Dr. medFriedrichPrallUniversität Rostock, Institut für PathologieAkademischeR BetreuerIndgs1028873808PD Dr. rer. nat.MichaelLinnebacherUniversität Rostock, Klinik und Poliklinik für ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.MathiasEvertUniversität Greifswald, Institut für PathologieAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001422[purl]http://purl.uni-rostock.de/rosdok/id00001422[urn]urn:nbn:de:gbv:28-diss2014-0174-3open_access20142014epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.umrstate:published