10.18453/rosdok_id00001422 Salem, Tareq Tareq Salem http://d-nb.info/gnd/1060187329 Universität Rostock 2014 610 Medical sciences Medicine 2014 en http://purl.uni-rostock.de/rosdok/id00001422 urn:nbn:de:gbv:28-diss2014-0174-3 This study was conducted to find out if the patterns of PTEN gene molecular aberration in colorectal carcinoma are consistent with the classic molecular features ascribed to a tumour suppressor gene. PTEN gene mutations and LOH were assayed in a series of 18 colorectal carcinomas. Three PTEN gene mutations were found in 1 tumour, complete loss of one allele(LOH)in 2 tumours and allelic imbalance (AI) in 6 tumours. LOH or AI did not target the 1 tumour with the PTEN gene mutations. The widely held belief of PTEN as a classical tumour suppressor gene is not supported by the findings from this study.