mycoreobjectrosdok_disshab_0000001278rosdok_disshab_0000001278rosdokdisshabrosdok_derivate_00000237922023-08-08T10:05:31.878Z2015-02-06T12:49:14.111ZadministratoreditorDpublished1rosdok_derivate_0000023792truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001457817694552MODS updated during RosDok migration in June 2021DissertationHochschulschrift1049755472HeikoLemcke1982-VerfasserInautThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsenDr. rer. nat.SergeiKuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgs136256864Prof. Dr. med.ArndtRolfsUniversität Rostock, Universitätsmedizin, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001457http://purl.uni-rostock.de/rosdok/id00001457urn:nbn:de:gbv:28-diss2015-0007-1610 Medizin, Gesundheit570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20132015Universitätsbibliothek RostockRostock20152015Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.Connexin43EGF/EGFR signallingneural differentiationgrowth factorPublikationen aus der Arbeit sind zu finden unter: http://www.ncbi.nlm.nih.gov/pubmed/24012498 http://www.ncbi.nlm.nih.gov/pubmed/23607708Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001457doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences MedicineSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/The role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsgnd:1049755472gnd:136256864gnd:2147083-2gnd:1049755472gnd:136256864gnd:2147083-2rosdok_disshab_0000001278-d98670e39gnd:1049755472Heiko LemckeHeiko Lemckerosdok_disshab_0000001278-d98670e60Dr. rer. nat. Sergei KuznetsovDr. rer. nat. Sergei Kuznetsovrosdok_disshab_0000001278-d98670e73gnd:136256864Prof. Dr. med. Arndt RolfsProf. Dr. med. Arndt Rolfsrosdok_disshab_0000001278-d98670e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeDr. rer. nat. Sergei KuznetsovProf. Dr. med. Arndt RolfsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeDr. rer. nat. Sergei KuznetsovProf. Dr. med. Arndt RolfsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001457http://purl.uni-rostock.de/rosdok/id00001457urn:nbn:de:gbv:28-diss2015-0007-1Connexin43EGF/EGFR signallingneural differentiationgrowth factorOur findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.20152015Publikationen aus der Arbeit sind zu finden unter: http://www.ncbi.nlm.nih.gov/pubmed/24012498 http://www.ncbi.nlm.nih.gov/pubmed/23607708epub.dissertation1 Dissertation_Lemcke_2015.pdf 13413726 61af69bd4f9c2491cfaa83d7463b5e94 rosdok/id00001457817694552MODS updated during RosDok migration in June 2021DissertationHochschulschrift1049755472HeikoLemcke1982-VerfasserInautThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsenDr. rer. nat.SergeiKuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgs136256864Prof. Dr. med.ArndtRolfsUniversität Rostock, Universitätsmedizin, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001457http://purl.uni-rostock.de/rosdok/id00001457urn:nbn:de:gbv:28-diss2015-0007-1610 Medizin, Gesundheit570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20132015Universitätsbibliothek RostockRostock20152015Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.Connexin43EGF/EGFR signallingneural differentiationgrowth factorPublikationen aus der Arbeit sind zu finden unter: http://www.ncbi.nlm.nih.gov/pubmed/24012498 http://www.ncbi.nlm.nih.gov/pubmed/23607708Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001457 2015-02-06T12:49:14.111Z 2023-08-08T10:05:31.878Z 2023-08-18T10:05:31.883Z editorD {"identifier":"rosdok/id00001457","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:13:17.739Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001457","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:13:17.927Z","registered":"2018-06-30T13:13:17.927Z"} {"identifier":"10.18453/rosdok_id00001457","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:13:19.248Z","registered":"2018-06-30T13:13:19.248Z"} {"identifier":"urn:nbn:de:gbv:28-diss2015-0007-1","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:13:17.744Z","registered":"2015-02-10T03:11:13.493Z"} administratorfulltextfile/rosdok_disshab_0000001278/rosdok_derivate_0000023792/Dissertation_Lemcke_2015.pdfThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsgnd:1049755472gnd:136256864gnd:2147083-2gnd:1049755472gnd:136256864gnd:2147083-2rosdok_disshab_0000001278-d98670e39gnd:1049755472Heiko LemckeHeiko Lemckerosdok_disshab_0000001278-d98670e60Dr. rer. nat. Sergei KuznetsovDr. rer. nat. Sergei Kuznetsovrosdok_disshab_0000001278-d98670e73gnd:136256864Prof. Dr. med. Arndt RolfsProf. Dr. med. Arndt Rolfsrosdok_disshab_0000001278-d98670e88gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeDr. rer. nat. Sergei KuznetsovProf. Dr. med. Arndt RolfsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeDr. rer. nat. Sergei KuznetsovProf. Dr. med. Arndt RolfsUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätHeiko LemckeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001457http://purl.uni-rostock.de/rosdok/id00001457urn:nbn:de:gbv:28-diss2015-0007-1Connexin43EGF/EGFR signallingneural differentiationgrowth factorOur findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects of growth factors. 2) GJIC is required to complete neuronal differentiation, including the establishment of a neural network. However, uncoupling of cells is crucial in the early stage of differentiation during cell fate commitment. Further, we showed that Cx43 regulates neuronal cell-fate.20152015Publikationen aus der Arbeit sind zu finden unter: http://www.ncbi.nlm.nih.gov/pubmed/24012498 http://www.ncbi.nlm.nih.gov/pubmed/23607708[xslt]Saxonrosdok/id00001457https://purl.uni-rostock.de/rosdok/id0000145781769455210.18453/rosdok_id00001457urn:nbn:de:gbv:28-diss2015-0007-1Heiko LemckeLemcke HeikoThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsDissertationdoctoral thesisUniversität Rostock, 2015Our findings provide a dual function of connexin43 (Cx43) and gap junctional intercellular communication (GJIC) in the neural development of human progenitor cells. 1) GJIC accompanied by high Cx43 expression is necessary to maintain cells in a proliferative state by mediating the mitogenic effects…Heiko LemckeThe role of gap junctional intercellular communication and connexins in the differentiation of human neural progenitor cellsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000014571049755472HeikoLemcke1982-VerfasserInautDr. rer. nat.SergeiKuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgs136256864Prof. Dr. med.ArndtRolfsUniversität Rostock, Universitätsmedizin, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001457[purl]http://purl.uni-rostock.de/rosdok/id00001457[urn]urn:nbn:de:gbv:28-diss2015-0007-1open_access20152015epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610SDNB:570institution:unirostock.mnfstate:published