Exploration of new sustainable synthetic methods for the synthesis of fused pyridines and 4-quinolones based on the domino reaction of chromones and other masked dielectrophiles with nucleophiles

10.18453/rosdok_id00001477 Mkrtchyan, Satenik Satenik Mkrtchyan http://d-nb.info/gnd/1064970052 Exploration of new sustainable synthetic methods for the synthesis of fused pyridines and 4-quinolones based on the domino reaction of chromones and other masked dielectrophiles with nucleophiles Universität Rostock 2015 540 Chemistry & allied sciences 2015 en http://purl.uni-rostock.de/rosdok/id00001477 urn:nbn:de:gbv:28-diss2015-0027-2 The present work aimed to study the big potential of chromone derivatives and 1-(2-fluorophenyl)prop-2-yn-1-ones for the synthesis of purine-like fused pyridines and 4-quinolone derivatives. In this regard, a wide range of substituents and substitution patterns are tolerated in the reaction. In addition a new and easy way for synthesis of 4-quinolone derivatives and other fused systems via domino cycloaddition reactions of ortho-fluoro substituted benzoylchromones, 1-(2-fluorophenyl)prop-2-yn-1-ones and aliphatic or aromatic amines were developed.