mycoreobjectrosdok_disshab_0000001369rosdok_disshab_0000001369rosdokdisshabrosdok_derivate_00000278682023-08-08T10:05:57.979Z2015-06-08T09:05:21.077ZadministratoreditorDpublished1rosdok_derivate_0000027868truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001548827024207MODS updated during RosDok migration in June 2021DissertationHochschulschrift1071833413MadhanThamilarasan1981-VerfasserInautMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsen120760819Prof. Dr. med.UweZettlUniversity of Rostock, Department of NeurologyAkademischeR BetreuerIndgsProf. Dr. med.FriedemannPaulCharité, Berlin, NeuroCure Clinical Research CenterAkademischeR BetreuerIndgsDr. med.JürgenFaissAsklepios Klinikum Teupitz, Department of NeurologyAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001548http://purl.uni-rostock.de/rosdok/id00001548urn:nbn:de:gbv:28-diss2015-0098-2610 Medizin, Gesundheit570 Biowissenschaften, BiologieUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20152015Universitätsbibliothek RostockRostock20152015Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.neuroimmunologyimmunomodulatory treatmentgene expression profilingUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001548doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences MedicineSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/MicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsgnd:1071833413gnd:120760819gnd:1029510660gnd:1071833413gnd:120760819gnd:1029510660rosdok_disshab_0000001369-d1089270e39gnd:1071833413Madhan ThamilarasanMadhan Thamilarasanrosdok_disshab_0000001369-d1089270e60gnd:120760819Prof. Dr. med. Uwe ZettlProf. Dr. med. Uwe Zettlrosdok_disshab_0000001369-d1089270e75Prof. Dr. med. Friedemann PaulProf. Dr. med. Friedemann Paulrosdok_disshab_0000001369-d1089270e88Dr. med. Jürgen FaissDr. med. Jürgen Faissrosdok_disshab_0000001369-d1089270e102gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinMadhan ThamilarasanProf. Dr. med. Uwe ZettlProf. Dr. med. Friedemann PaulDr. med. Jürgen FaissUniversität Rostock UniversitätsmedizinMadhan ThamilarasanProf. Dr. med. Uwe ZettlProf. Dr. med. Friedemann PaulDr. med. Jürgen FaissUniversität Rostock UniversitätsmedizinMadhan ThamilarasanRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001548http://purl.uni-rostock.de/rosdok/id00001548urn:nbn:de:gbv:28-diss2015-0098-2neuroimmunologyimmunomodulatory treatmentgene expression profilingMultiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.20152015epub.dissertation1 Dissertation_Thamilarasan_2015.pdf 4980381 9ff3bb84f9a7cdc8992dd1875533508a rosdok/id00001548827024207MODS updated during RosDok migration in June 2021DissertationHochschulschrift1071833413MadhanThamilarasan1981-VerfasserInautMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsen120760819Prof. Dr. med.UweZettlUniversity of Rostock, Department of NeurologyAkademischeR BetreuerIndgsProf. Dr. med.FriedemannPaulCharité, Berlin, NeuroCure Clinical Research CenterAkademischeR BetreuerIndgsDr. med.JürgenFaissAsklepios Klinikum Teupitz, Department of NeurologyAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001548http://purl.uni-rostock.de/rosdok/id00001548urn:nbn:de:gbv:28-diss2015-0098-2610 Medizin, Gesundheit570 Biowissenschaften, BiologieUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20152015Universitätsbibliothek RostockRostock20152015Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.neuroimmunologyimmunomodulatory treatmentgene expression profilingUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001548 2015-06-08T09:05:21.077Z 2023-08-08T10:05:57.979Z 2023-08-18T10:05:57.985Z editorD {"identifier":"rosdok/id00001548","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:16:28.617Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001548","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:16:28.807Z","registered":"2018-06-30T13:16:28.807Z"} {"identifier":"10.18453/rosdok_id00001548","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:16:30.116Z","registered":"2018-06-30T13:16:30.116Z"} {"identifier":"urn:nbn:de:gbv:28-diss2015-0098-2","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:16:28.623Z","registered":"2015-06-11T02:27:28.657Z"} administratorfulltextfile/rosdok_disshab_0000001369/rosdok_derivate_0000027868/Dissertation_Thamilarasan_2015.pdfMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsgnd:1071833413gnd:120760819gnd:1029510660gnd:1071833413gnd:120760819gnd:1029510660rosdok_disshab_0000001369-d1089270e39gnd:1071833413Madhan ThamilarasanMadhan Thamilarasanrosdok_disshab_0000001369-d1089270e60gnd:120760819Prof. Dr. med. Uwe ZettlProf. Dr. med. Uwe Zettlrosdok_disshab_0000001369-d1089270e75Prof. Dr. med. Friedemann PaulProf. Dr. med. Friedemann Paulrosdok_disshab_0000001369-d1089270e88Dr. med. Jürgen FaissDr. med. Jürgen Faissrosdok_disshab_0000001369-d1089270e102gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinMadhan ThamilarasanProf. Dr. med. Uwe ZettlProf. Dr. med. Friedemann PaulDr. med. Jürgen FaissUniversität Rostock UniversitätsmedizinMadhan ThamilarasanProf. Dr. med. Uwe ZettlProf. Dr. med. Friedemann PaulDr. med. Jürgen FaissUniversität Rostock UniversitätsmedizinMadhan ThamilarasanRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001548http://purl.uni-rostock.de/rosdok/id00001548urn:nbn:de:gbv:28-diss2015-0098-2neuroimmunologyimmunomodulatory treatmentgene expression profilingMultiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment with glatiramer acetate (GA) and interferon-beta-1b. The studies reported revealed several differentially expressed transcripts which included both mRNAs and microRNAs. These can be considered as biomarkers for therapy monitoring and help to better understand the mechanisms of action of the drugs.20152015[xslt]Saxonrosdok/id00001548https://purl.uni-rostock.de/rosdok/id0000154882702420710.18453/rosdok_id00001548urn:nbn:de:gbv:28-diss2015-0098-2Madhan ThamilarasanThamilarasan MadhanMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsDissertationdoctoral thesisUniversität Rostock, 2015Multiple sclerosis (MS) is an inflammatory disease of the central nervous system. There are many types of disease-modifying drugs available but none of them can cure MS. The studies reported in this thesis analyzed the changes which happen at the transcriptome level during the course of treatment…Madhan ThamilarasanMicroRNA and messengerRNA expression changes during interferon-beta and glatiramer acetate treatment in peripheral blood cells of multiple sclerosis patientsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000015481071833413MadhanThamilarasan1981-VerfasserInaut120760819Prof. Dr. med.UweZettlUniversity of Rostock, Department of NeurologyAkademischeR BetreuerIndgsProf. Dr. med.FriedemannPaulCharité, Berlin, NeuroCure Clinical Research CenterAkademischeR BetreuerIndgsDr. med.JürgenFaissAsklepios Klinikum Teupitz, Department of NeurologyAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001548[purl]http://purl.uni-rostock.de/rosdok/id00001548[urn]urn:nbn:de:gbv:28-diss2015-0098-2open_access20152015epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610SDNB:570institution:unirostock.umrstate:published