mycoreobjectrosdok_disshab_0000001417rosdok_disshab_0000001417rosdokdisshabrosdok_derivate_00000290972023-08-08T10:06:12.486Z2015-08-19T16:52:41.239ZadministratoreditorDpublished1rosdok_derivate_0000029097truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001596833973207MODS updated during RosDok migration in June 2021DissertationHochschulschrift1075814340MarionLudwig1984-VerfasserInautThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDas regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivoen136129560Prof. Dr. med.GustavSteinhoffUniversität Rostock, Klinik und Poliklinik für HerzchirurgieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrikeGimsaUniversität Rostock; FBN Dummerstorf, ImmunologieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrichMartinMedizinische Hochschule Hannover, Klinik für Thorax-, Herz- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001596http://purl.uni-rostock.de/rosdok/id00001596urn:nbn:de:gbv:28-diss2015-0146-3610 Medizin, GesundheitMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20152015Universitätsbibliothek RostockRostock20152015Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.CD117+ stem cellstransient AT2R stimulationcardiac stem cell therapyvasculogenesiscardioprotectionUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001596doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/The regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDas regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivoThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivognd:1075814340gnd:136129560gnd:2147083-2gnd:1075814340gnd:136129560gnd:2147083-2rosdok_disshab_0000001417-d3876442e39gnd:1075814340Marion LudwigMarion Ludwigrosdok_disshab_0000001417-d3876442e62gnd:136129560Prof. Dr. med. Gustav SteinhoffProf. Dr. med. Gustav Steinhoffrosdok_disshab_0000001417-d3876442e77Prof. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrike Gimsarosdok_disshab_0000001417-d3876442e91Prof. Dr. rer. nat. Ulrich MartinProf. Dr. rer. nat. Ulrich Martinrosdok_disshab_0000001417-d3876442e104gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrich MartinUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrich MartinUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001596http://purl.uni-rostock.de/rosdok/id00001596urn:nbn:de:gbv:28-diss2015-0146-3CD117+ stem cellstransient AT2R stimulationcardiac stem cell therapyvasculogenesiscardioprotectionRegarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.20152015epub.dissertation1 Dissertation_Ludwig_2015.pdf 1647720 a52a5782c39a01a1be9a4aff7254c765 rosdok/id00001596833973207MODS updated during RosDok migration in June 2021DissertationHochschulschrift1075814340MarionLudwig1984-VerfasserInautThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDas regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivoen136129560Prof. Dr. med.GustavSteinhoffUniversität Rostock, Klinik und Poliklinik für HerzchirurgieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrikeGimsaUniversität Rostock; FBN Dummerstorf, ImmunologieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrichMartinMedizinische Hochschule Hannover, Klinik für Thorax-, Herz- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001596http://purl.uni-rostock.de/rosdok/id00001596urn:nbn:de:gbv:28-diss2015-0146-3610 Medizin, GesundheitMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2015monographic20152015Universitätsbibliothek RostockRostock20152015Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.CD117+ stem cellstransient AT2R stimulationcardiac stem cell therapyvasculogenesiscardioprotectionUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001596 2015-08-19T16:52:41.239Z 2023-08-08T10:06:12.486Z 2023-08-18T10:06:12.491Z editorD {"identifier":"rosdok/id00001596","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:18:10.877Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001596","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:18:11.055Z","registered":"2018-06-30T13:18:11.055Z"} {"identifier":"10.18453/rosdok_id00001596","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:18:12.432Z","registered":"2018-06-30T13:18:12.432Z"} {"identifier":"urn:nbn:de:gbv:28-diss2015-0146-3","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:18:10.883Z","registered":"2015-08-27T02:22:50.353Z"} administratorfulltextfile/rosdok_disshab_0000001417/rosdok_derivate_0000029097/Dissertation_Ludwig_2015.pdfThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDas regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivoThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivognd:1075814340gnd:136129560gnd:2147083-2gnd:1075814340gnd:136129560gnd:2147083-2rosdok_disshab_0000001417-d3876442e39gnd:1075814340Marion LudwigMarion Ludwigrosdok_disshab_0000001417-d3876442e62gnd:136129560Prof. Dr. med. Gustav SteinhoffProf. Dr. med. Gustav Steinhoffrosdok_disshab_0000001417-d3876442e77Prof. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrike Gimsarosdok_disshab_0000001417-d3876442e91Prof. Dr. rer. nat. Ulrich MartinProf. Dr. rer. nat. Ulrich Martinrosdok_disshab_0000001417-d3876442e104gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrich MartinUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigProf. Dr. med. Gustav SteinhoffProf. Dr. rer. nat. Ulrike GimsaProf. Dr. rer. nat. Ulrich MartinUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätMarion LudwigRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001596http://purl.uni-rostock.de/rosdok/id00001596urn:nbn:de:gbv:28-diss2015-0146-3CD117+ stem cellstransient AT2R stimulationcardiac stem cell therapyvasculogenesiscardioprotectionRegarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.20152015[xslt]Saxonrosdok/id00001596https://purl.uni-rostock.de/rosdok/id0000159683397320710.18453/rosdok_id00001596urn:nbn:de:gbv:28-diss2015-0146-3Marion LudwigLudwig MarionThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDissertationdoctoral thesisUniversität Rostock, 2015Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a…Marion LudwigThe regenerative potential of the CD117+AT2R stimulated cell population in vitro and in vivoDas regenerative Potential der CD117+AT2R stimulierten Zellpopulation in vitro und in vivoUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000015961075814340MarionLudwig1984-VerfasserInaut136129560Prof. Dr. med.GustavSteinhoffUniversität Rostock, Klinik und Poliklinik für HerzchirurgieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrikeGimsaUniversität Rostock; FBN Dummerstorf, ImmunologieAkademischeR BetreuerIndgsProf. Dr. rer. nat.UlrichMartinMedizinische Hochschule Hannover, Klinik für Thorax-, Herz- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001596[purl]http://purl.uni-rostock.de/rosdok/id00001596[urn]urn:nbn:de:gbv:28-diss2015-0146-3open_access20152015epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.mnfstate:published