10.18453/rosdok_id00001596 Ludwig, Marion Marion Ludwig http://d-nb.info/gnd/1075814340 Universität Rostock 2015 610 Medical sciences Medicine 2015 en http://purl.uni-rostock.de/rosdok/id00001596 urn:nbn:de:gbv:28-diss2015-0146-3 Regarding innovative therapeutical approaches for cardiac regeneration, we thoroughly investigated CD117+ and CD117+AT2R stimulated murine bone marrow stem cells. Electrophysiological measurements and in vitro results indicated the differentiation into an endothelial-like phenotype excluding a previously discussed development into cardiomyocytes. Cell implantation into infarcted murine heart provoked a significant improvement of cardiac function. AT2R triggered effects were not significantly different and should be analyzed in interplay with its opposing receptor AT1.