10.18453/rosdok_id00001634 Zheng, Youwei Youwei Zheng http://d-nb.info/gnd/1079690727 Universität Rostock 2015 000 Generalities, Science 570 Life science 2015 en http://purl.uni-rostock.de/rosdok/id00001634 urn:nbn:de:gbv:28-diss2015-0184-4 A deeper understanding is required of how a single neuron utilizes its nonlinear subcellular devices to generate complex neuronal dynamics. Two compartmental models of cortex and striatum are accurately formulated and firmly grounded in the experimental reality of electrophysiology to address the questions: how striatal projection neurons implement location-dependent dendritic integration to carry out association-based computation and how cortical pyramidal neurons strategically exploit the type and location of synaptic contacts to enrich its computational capacities.