Synthesis of functionalized heterocycles via Pd-catalyzed aminocarbonylation using Mo(CO)6 as alternative CO-source and tandem cyclisation-condensation to access dihydroquinazolinones

10.18453/rosdok_id00001645 Oschatz, Stefan Stefan Oschatz http://d-nb.info/gnd/1079689117 Synthesis of functionalized heterocycles via Pd-catalyzed aminocarbonylation using Mo(CO)6 as alternative CO-source and tandem cyclisation-condensation to access dihydroquinazolinones Synthese funktionalisierter Heterozyklen via Pd-katalysierter Aminocarbonylierung mit Mo(CO)6 als Alternative CO-Quelle und Tandem-Zyklisierungs-Kondensation zum Erhalt von Dihydrochinazolinonen Universität Rostock 2015 540 Chemistry & allied sciences 2015 en http://purl.uni-rostock.de/rosdok/id00001645 urn:nbn:de:gbv:28-diss2015-0195-9 The aim of this work was the devewlopement of Pd-catalyzed aminocarbonylative cross coupling reactions to obtain various amide scaffolds. These syntheses were performed with the use of molybdenum hexacarbonyl as alternative CO source to avoid the application of gaseous carbon monoxide. The second part of the work focused on tandem condensation-cyclisation reactions of 2-amino-benzonitriles with aldehydes to give access to 1,2-dihydroquinazolinones. The condensation-cyclisation was furthermore performed using 2-amino-benzothioamides to allow for the synthesis of 1,2-dihydro-quinazolinthiones.