mycoreobjectrosdok_disshab_0000001588rosdok_disshab_0000001588rosdokdisshabrosdok_derivate_00000348152023-08-08T10:07:07.275Z2016-07-18T07:17:36.642ZadministratoreditorDpublished1rosdok_derivate_0000034815truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001767865456275MODS updated during RosDok migration in June 2021DissertationHochschulschrift1106336216FieteHaack1984-VerfasserInautExploring the spatio-temporal dynamics of lipid rafts and their role in Signal transductiona modeling and simulation approachen136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniverität Rostock, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.KevinBurrageQUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department of Computer ScienceAkademischeR BetreuerIndgs1018396683Prof. Dr. Dr. h.c.EddaKlippHumboldt-Universität zu Berlin, Institut für Biologie, Theoretische BiophysikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001767http://purl.uni-rostock.de/rosdok/id00001767urn:nbn:de:gbv:28-diss2016-0080-1004 Informatik570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20162016Universitätsbibliothek RostockRostock20162016The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.Wnt/beta-catenin signalingrule-based modellingcellular automatareactive oxygen speciesneural differentiationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001767doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:004SDNB:004004 Informatik004 Data processing Computer sciencesSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Exploring the spatio-temporal dynamics of lipid rafts and their role in Signal transductiona modeling and simulation approachExploring the spatio-temporal dynamics of lipid rafts and their role in Signal transductiona modeling and simulation approachgnd:1106336216gnd:136258794gnd:1018396683gnd:10085032-7gnd:1106336216gnd:136258794gnd:1018396683gnd:10085032-7rosdok_disshab_0000001588-d539393e39gnd:1106336216Fiete HaackFiete Haackrosdok_disshab_0000001588-d539393e61gnd:136258794Prof. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. rer. nat. habil. Adelinde M. Uhrmacherrosdok_disshab_0000001588-d539393e76Prof. Dr. Kevin BurrageProf. Dr. Kevin Burragerosdok_disshab_0000001588-d539393e89gnd:1018396683Prof. Dr. Dr. h.c. Edda KlippProf. Dr. Dr. h.c. Edda Klipprosdok_disshab_0000001588-d539393e105gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Kevin BurrageProf. Dr. Dr. h.c. Edda KlippUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Kevin BurrageProf. Dr. Dr. h.c. Edda KlippUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001767http://purl.uni-rostock.de/rosdok/id00001767urn:nbn:de:gbv:28-diss2016-0080-1Wnt/beta-catenin signalingrule-based modellingcellular automatareactive oxygen speciesneural differentiationThe aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.20162016epub.dissertation1 Dissertation_Haack_2016.pdf 11679613 1e23aa671e2ab56c7ded03519c94cac8 rosdok/id00001767865456275MODS updated during RosDok migration in June 2021DissertationHochschulschrift1106336216FieteHaack1984-VerfasserInautExploring the spatio-temporal dynamics of lipid rafts and their role in Signal transductiona modeling and simulation approachen136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniverität Rostock, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.KevinBurrageQUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department of Computer ScienceAkademischeR BetreuerIndgs1018396683Prof. Dr. Dr. h.c.EddaKlippHumboldt-Universität zu Berlin, Institut für Biologie, Theoretische BiophysikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg10.18453/rosdok_id00001767http://purl.uni-rostock.de/rosdok/id00001767urn:nbn:de:gbv:28-diss2016-0080-1004 Informatik570 Biowissenschaften, BiologieFakultät für Informatik und Elektrotechnikfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20162016Universitätsbibliothek RostockRostock20162016The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. 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Adelinde M. UhrmacherProf. Dr. rer. nat. habil. Adelinde M. Uhrmacherrosdok_disshab_0000001588-d539393e76Prof. Dr. Kevin BurrageProf. Dr. Kevin Burragerosdok_disshab_0000001588-d539393e89gnd:1018396683Prof. Dr. Dr. h.c. Edda KlippProf. Dr. Dr. h.c. Edda Klipprosdok_disshab_0000001588-d539393e105gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Kevin BurrageProf. Dr. Dr. h.c. Edda KlippUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackProf. Dr. rer. nat. habil. Adelinde M. UhrmacherProf. Dr. Kevin BurrageProf. Dr. Dr. h.c. Edda KlippUniversität Rostock Fakultät für Informatik und ElektrotechnikFiete HaackRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001767http://purl.uni-rostock.de/rosdok/id00001767urn:nbn:de:gbv:28-diss2016-0080-1Wnt/beta-catenin signalingrule-based modellingcellular automatareactive oxygen speciesneural differentiationThe aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling pathway, is thoroughly analyzed. To explore the effect of lipid rafts on individual signaling events, a Cellular-Automata based membrane model is developed. The specific involvement of lipid rafts in Wnt/β-catenin signaling is explored by means of an integrated in silico and in vitro approach.20162016[xslt]Saxonrosdok/id00001767https://purl.uni-rostock.de/rosdok/id0000176786545627510.18453/rosdok_id00001767urn:nbn:de:gbv:28-diss2016-0080-1Fiete HaackHaack FieteExploring the spatio-temporal dynamics of lipid rafts and their role in Signal transduction : a modeling and simulation approachDissertationdoctoral thesisUniversität Rostock, 2016The aim of this thesis is to elucidate the biological as well as methodological implications that arise from modeling the spatio-temporal dynamics of lipid rafts. Therefore the effect of raft-dependent receptors dynamics on both, individual signaling events as well as the canonical Wnt signaling…Fiete HaackExploring the spatio-temporal dynamics of lipid rafts and their role in Signal transductiona modeling and simulation approachUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000017671106336216FieteHaack1984-VerfasserInaut136258794Prof. Dr. rer. nat. habil.Adelinde M.UhrmacherUniverität Rostock, Institut für InformatikAkademischeR BetreuerIndgsProf. Dr.KevinBurrageQUT, Brisbane, Australia; University of Oxford, UK, Computational Mathematics; Department of Computer ScienceAkademischeR BetreuerIndgs1018396683Prof. Dr. Dr. h.c.EddaKlippHumboldt-Universität zu Berlin, Institut für Biologie, Theoretische BiophysikAkademischeR BetreuerIndgs10085032-7Universität RostockFakultät für Informatik und ElektrotechnikGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001767[purl]http://purl.uni-rostock.de/rosdok/id00001767[urn]urn:nbn:de:gbv:28-diss2016-0080-1open_access20162016epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:004SDNB:570institution:unirostock.iefstate:published