10.18453/rosdok_id00001770
Hofrichter, Jacqueline
Jacqueline
Hofrichter
http://d-nb.info/gnd/107190275X
The influence of plant extracts on β-Amyloid induced pathologies in an APP/PS1 mouse model of Alzheimer‘s disease
Der Einfluss von Pflanzenextrakten auf die β-Amyloid induzierte Pathogenese in einem APP/PS1 Mausmodell der Alzheimer Demenz
Universität Rostock
2016
570 Life science
2016
en
http://purl.uni-rostock.de/rosdok/id00001770
urn:nbn:de:gbv:28-diss2016-0083-8
The study explored the influence of plant extracts on neuronal degeneration caused by toxic β-amyloid in a transgenic APP/PS1 mouse model of Alzheimer‘s disease. Daily oral application of extracts of Hypericum perforatum and Sideritis spp. attenuated Aβ-induced histopathology and alleviated memory impairments in APP/PS1 mice. In detail, both extracts (i) decreased intracerebral Aβ42 and (ii) Aβ plaques, (iii) rescued neocortical neurons, and (iv) restored cognition to healthy control levels due to an enhanced Aβ42 export activity of ABCC1 and an increased phagocytic microglia activity.