mycoreobjectrosdok_disshab_0000001593rosdok_disshab_0000001593rosdokdisshabrosdok_derivate_00000348102023-08-08T10:07:09.975Z2016-07-18T07:26:56.995ZadministratoreditorDpublished1rosdok_derivate_0000034810truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001772865476136MODS updated during RosDok migration in June 2021DissertationHochschulschrift1074969685ThiloStorm1974-VerfasserInautInfluence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfaceen131807838Prof. Dr.BirgitPiechullaUniversität Rostock, Institut für BiowissenschaftenAkademischeR BetreuerIndgs138627258PD Dr.MarinaHovakimyanUniversität Rostock, Institut für Biomedizinische TechnikAkademischeR BetreuerIndgs120982145Prof. Dr.MathiasWilhelmiMedizinische Hochschule Hannover, Klinik für Herz-, Thorax-, Transplantations- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001772http://purl.uni-rostock.de/rosdok/id00001772urn:nbn:de:gbv:28-diss2016-0085-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20152016Universitätsbibliothek RostockRostock20162016The response of human endothelial cells (ECs) to poly(ε-caprolactone) (PCL) and eight different PCL modifications was examined in vitro. In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their maximum response was again seen on plasma activated PCL. Polymer precoating with matrix proteins was found to be beneficial for EC adhesion. A qPCR study of eNOS, IL-8, ICAM-1, PECAM-1 and VCAM-1 transcripts after VEGF stimulation of ECs on four modified and coated PCL surfaces was also performed.coronary artery diseaseHUVEC HCAECPCL biomaterial functionalizationVEGFECM protein precoatingmRNA expression of endothelial marker moleculesUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001772doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Influence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfaceInfluence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfacegnd:1074969685gnd:131807838gnd:138627258gnd:120982145gnd:2147083-2gnd:1074969685gnd:131807838gnd:138627258gnd:120982145gnd:2147083-2rosdok_disshab_0000001593-d68931e39gnd:1074969685Thilo StormThilo Stormrosdok_disshab_0000001593-d68931e60gnd:131807838Prof. Dr. Birgit PiechullaProf. Dr. Birgit Piechullarosdok_disshab_0000001593-d68931e75gnd:138627258PD Dr. Marina HovakimyanPD Dr. Marina Hovakimyanrosdok_disshab_0000001593-d68931e90gnd:120982145Prof. Dr. Mathias WilhelmiProf. Dr. Mathias Wilhelmirosdok_disshab_0000001593-d68931e106gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätThilo StormProf. Dr. Birgit PiechullaPD Dr. Marina HovakimyanProf. Dr. Mathias WilhelmiUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätThilo StormProf. Dr. Birgit PiechullaPD Dr. Marina HovakimyanProf. Dr. Mathias WilhelmiUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätThilo StormRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001772http://purl.uni-rostock.de/rosdok/id00001772urn:nbn:de:gbv:28-diss2016-0085-0coronary artery diseaseHUVEC HCAECPCL biomaterial functionalizationVEGFECM protein precoatingmRNA expression of endothelial marker moleculesThe response of human endothelial cells (ECs) to poly(ε-caprolactone) (PCL) and eight different PCL modifications was examined in vitro. In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their maximum response was again seen on plasma activated PCL. Polymer precoating with matrix proteins was found to be beneficial for EC adhesion. A qPCR study of eNOS, IL-8, ICAM-1, PECAM-1 and VCAM-1 transcripts after VEGF stimulation of ECs on four modified and coated PCL surfaces was also performed.20162016epub.dissertation1 Dissertation_Storm_2016.pdf 4145275 fac5fc24c4d6e6c72dacfb054a3029cc rosdok/id00001772865476136MODS updated during RosDok migration in June 2021DissertationHochschulschrift1074969685ThiloStorm1974-VerfasserInautInfluence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfaceen131807838Prof. Dr.BirgitPiechullaUniversität Rostock, Institut für BiowissenschaftenAkademischeR BetreuerIndgs138627258PD Dr.MarinaHovakimyanUniversität Rostock, Institut für Biomedizinische TechnikAkademischeR BetreuerIndgs120982145Prof. Dr.MathiasWilhelmiMedizinische Hochschule Hannover, Klinik für Herz-, Thorax-, Transplantations- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg10.18453/rosdok_id00001772http://purl.uni-rostock.de/rosdok/id00001772urn:nbn:de:gbv:28-diss2016-0085-0570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20152016Universitätsbibliothek RostockRostock20162016The response of human endothelial cells (ECs) to poly(ε-caprolactone) (PCL) and eight different PCL modifications was examined in vitro. In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their maximum response was again seen on plasma activated PCL. Polymer precoating with matrix proteins was found to be beneficial for EC adhesion. 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In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their maximum response was again seen on plasma activated PCL. Polymer precoating with matrix proteins was found to be beneficial for EC adhesion. A qPCR study of eNOS, IL-8, ICAM-1, PECAM-1 and VCAM-1 transcripts after VEGF stimulation of ECs on four modified and coated PCL surfaces was also performed.20162016[xslt]Saxonrosdok/id00001772https://purl.uni-rostock.de/rosdok/id0000177286547613610.18453/rosdok_id00001772urn:nbn:de:gbv:28-diss2016-0085-0Thilo StormStorm ThiloInfluence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfaceDissertationdoctoral thesisUniversität Rostock, 2016The response of human endothelial cells (ECs) to poly(ε-caprolactone) (PCL) and eight different PCL modifications was examined in vitro. In CLSM, cell proliferation and viability testing, ECs responded best to plasma chemical activation of PCL. When ECs were additionally stimulated by VEGF, their…Thilo StormInfluence of polymer surface modification and specific growth factor stimulation on cellular adhesion at the implant/endothelium interfaceUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000017721074969685ThiloStorm1974-VerfasserInaut131807838Prof. Dr.BirgitPiechullaUniversität Rostock, Institut für BiowissenschaftenAkademischeR BetreuerIndgs138627258PD Dr.MarinaHovakimyanUniversität Rostock, Institut für Biomedizinische TechnikAkademischeR BetreuerIndgs120982145Prof. Dr.MathiasWilhelmiMedizinische Hochschule Hannover, Klinik für Herz-, Thorax-, Transplantations- und GefäßchirurgieAkademischeR BetreuerIndgs2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001772[purl]http://purl.uni-rostock.de/rosdok/id00001772[urn]urn:nbn:de:gbv:28-diss2016-0085-0open_access20162016epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published