mycoreobjectrosdok_disshab_0000001607rosdok_disshab_0000001607rosdokdisshabrosdok_derivate_00000348262023-08-08T10:07:14.921Z2016-08-12T08:47:36.579ZadministratoreditorDpublished1rosdok_derivate_0000034826truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001785865832447MODS updated during RosDok migration in June 2021DissertationHochschulschrift1111521808CarolineMörke1989-VerfasserInautCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsen172943744Prof. Dr.BarbaraNebeUniversitätsmedizin Rostock, Zentrum für Medizinische Forschung, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgsPD Dr.Sergei A.KuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsProf. Dr.Jande BoerUniversity of Twente, Institute for Biomedical Technology and Technical MedicineAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001785http://purl.uni-rostock.de/rosdok/id00001785urn:nbn:de:gbv:28-diss2016-0099-5570 Biowissenschaften, BiologieUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20162016Universitätsbibliothek RostockRostock20162016Cells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces.cell biologyendocytosisimplantUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001785doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Caveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsgnd:1111521808gnd:172943744gnd:1029510660gnd:1111521808gnd:172943744gnd:1029510660rosdok_disshab_0000001607-d752689e39gnd:1111521808Caroline MörkeCaroline Mörkerosdok_disshab_0000001607-d752689e60gnd:172943744Prof. Dr. Barbara NebeProf. Dr. Barbara Neberosdok_disshab_0000001607-d752689e75PD Dr. Sergei A. KuznetsovPD Dr. Sergei A. Kuznetsovrosdok_disshab_0000001607-d752689e88Prof. Dr. Jan de BoerProf. Dr. Jan de Boerrosdok_disshab_0000001607-d752689e102gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinCaroline MörkeProf. Dr. Barbara NebePD Dr. Sergei A. KuznetsovProf. Dr. Jan de BoerUniversität Rostock UniversitätsmedizinCaroline MörkeProf. Dr. Barbara NebePD Dr. Sergei A. KuznetsovProf. Dr. Jan de BoerUniversität Rostock UniversitätsmedizinCaroline MörkeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001785http://purl.uni-rostock.de/rosdok/id00001785urn:nbn:de:gbv:28-diss2016-0099-5cell biologyendocytosisimplantCells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces.20162016epub.dissertation1 Dissertation_Moerke_2016.pdf 5995004 437c1fe5ba6ff3a80abd0437cbb074ca rosdok/id00001785865832447MODS updated during RosDok migration in June 2021DissertationHochschulschrift1111521808CarolineMörke1989-VerfasserInautCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsen172943744Prof. Dr.BarbaraNebeUniversitätsmedizin Rostock, Zentrum für Medizinische Forschung, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgsPD Dr.Sergei A.KuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsProf. Dr.Jande BoerUniversity of Twente, Institute for Biomedical Technology and Technical MedicineAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001785http://purl.uni-rostock.de/rosdok/id00001785urn:nbn:de:gbv:28-diss2016-0099-5570 Biowissenschaften, BiologieUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20162016Universitätsbibliothek RostockRostock20162016Cells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces.cell biologyendocytosisimplantUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001785 2016-08-12T08:47:36.579Z 2023-08-08T10:07:14.921Z 2023-08-18T10:07:14.926Z editorD {"identifier":"rosdok/id00001785","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:24:55.318Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001785","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:24:55.496Z","registered":"2018-06-30T13:24:55.496Z"} {"identifier":"10.18453/rosdok_id00001785","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:24:56.815Z","registered":"2018-06-30T13:24:56.815Z"} {"identifier":"urn:nbn:de:gbv:28-diss2016-0099-5","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:24:55.324Z","registered":"2016-08-18T02:00:42.863Z"} administratorfulltextfile/rosdok_disshab_0000001607/rosdok_derivate_0000034826/Dissertation_Moerke_2016.pdfCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsgnd:1111521808gnd:172943744gnd:1029510660gnd:1111521808gnd:172943744gnd:1029510660rosdok_disshab_0000001607-d752689e39gnd:1111521808Caroline MörkeCaroline Mörkerosdok_disshab_0000001607-d752689e60gnd:172943744Prof. Dr. Barbara NebeProf. Dr. Barbara Neberosdok_disshab_0000001607-d752689e75PD Dr. Sergei A. KuznetsovPD Dr. Sergei A. Kuznetsovrosdok_disshab_0000001607-d752689e88Prof. Dr. Jan de BoerProf. Dr. Jan de Boerrosdok_disshab_0000001607-d752689e102gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinCaroline MörkeProf. Dr. Barbara NebePD Dr. Sergei A. KuznetsovProf. Dr. Jan de BoerUniversität Rostock UniversitätsmedizinCaroline MörkeProf. Dr. Barbara NebePD Dr. Sergei A. KuznetsovProf. Dr. Jan de BoerUniversität Rostock UniversitätsmedizinCaroline MörkeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001785http://purl.uni-rostock.de/rosdok/id00001785urn:nbn:de:gbv:28-diss2016-0099-5cell biologyendocytosisimplantCells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in higher energy requirements for the cells and finally to impaired osteoblast function. Similar cell responses were observed for the osteoblasts treated with micro-particles as phagocytosis trigger and osteoblasts growing on stochastic rough Ti surfaces, commercially used as implant surfaces.20162016[xslt]Saxonrosdok/id00001785https://purl.uni-rostock.de/rosdok/id0000178586583244710.18453/rosdok_id00001785urn:nbn:de:gbv:28-diss2016-0099-5Caroline MörkeMörke CarolineCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsDissertationdoctoral thesisUniversität Rostock, 2016Cells are sensitive to their underlying topography, which evoke large ranges of cell responses. The work describes an attempted caveolae-mediated phagocytosis of the surface-fixed micro-pillars by human MG-63 osteoblastic cells. This attempt to phagocytize the elevations of the Ti surface results in…Caroline MörkeCaveolae-mediated phagocytosis of biomaterial surface structures by human osteoblastsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000017851111521808CarolineMörke1989-VerfasserInaut172943744Prof. Dr.BarbaraNebeUniversitätsmedizin Rostock, Zentrum für Medizinische Forschung, Arbeitsbereich ZellbiologieAkademischeR BetreuerIndgsPD Dr.Sergei A.KuznetsovUniversität Rostock, Institut für Biowissenschaften, Abteilung TierphysiologieAkademischeR BetreuerIndgsProf. Dr.Jande BoerUniversity of Twente, Institute for Biomedical Technology and Technical MedicineAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001785[purl]http://purl.uni-rostock.de/rosdok/id00001785[urn]urn:nbn:de:gbv:28-diss2016-0099-5open_access20162016epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.umrstate:published