mycoreobjectrosdok_disshab_0000001621rosdok_disshab_0000001621rosdokdisshabrosdok_derivate_00000348702023-08-08T10:07:18.708Z2016-09-29T12:42:40.996ZadministratoreditorDpublished1rosdok_derivate_0000034870truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001799870104012MODS updated during RosDok migration in June 2021DissertationHochschulschrift111215731XDr.LeilaTaher1978-VerfasserInautUnraveling the transcriptional Cis-regulatory codeenProf. Dr.WojciechMakalowskiWestfälische Wilhelms-Universität Münster, Institut für BioinformatikAkademischeR BetreuerIndgsProf. Dr.BurkhardMorgensternGeorg-August-Universität Göttingen, Institut für Mikrobiologie und GenetikAkademischeR BetreuerIndgs140626085Prof. Dr.GeorgFüllenUniversitätsmedizin Rostock, Institut für Biostatistik und Informatik in Medizin und Alterns- forschungAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001799http://purl.uni-rostock.de/rosdok/id00001799urn:nbn:de:gbv:28-diss2016-0113-4570 Biowissenschaften, BiologieUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2016monographic20162016Universitätsbibliothek RostockRostock20162016It is nowadays accepted that eukaryotic complexity is not dictated by the number of protein-coding genes of the genome, but rather achieved through the combinatorics of gene expression programs. Distinct aspects of the expression pattern of a gene are mediated by discrete regulatory sequences, known as cis-regulatory elements. The work described in this thesis was aimed at developing computational and statistical methods to guide the search and characterization of novel cis-regulatory elements.functional genomicstranscriptional regulationsequence analysisUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001799doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Unraveling the transcriptional Cis-regulatory codeUnraveling the transcriptional Cis-regulatory codegnd:111215731Xgnd:140626085gnd:1029510660gnd:111215731Xgnd:140626085gnd:1029510660rosdok_disshab_0000001621-d499108e39gnd:111215731XDr. Leila TaherDr. Leila Taherrosdok_disshab_0000001621-d499108e62Prof. Dr. Wojciech MakalowskiProf. Dr. Wojciech Makalowskirosdok_disshab_0000001621-d499108e75Prof. Dr. Burkhard MorgensternProf. Dr. Burkhard Morgensternrosdok_disshab_0000001621-d499108e88gnd:140626085Prof. Dr. Georg FüllenProf. Dr. Georg Füllenrosdok_disshab_0000001621-d499108e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinDr. Leila TaherProf. Dr. Wojciech MakalowskiProf. Dr. Burkhard MorgensternProf. Dr. Georg FüllenUniversität Rostock UniversitätsmedizinDr. Leila TaherProf. Dr. Wojciech MakalowskiProf. Dr. Burkhard MorgensternProf. Dr. Georg FüllenUniversität Rostock UniversitätsmedizinDr. Leila TaherRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001799http://purl.uni-rostock.de/rosdok/id00001799urn:nbn:de:gbv:28-diss2016-0113-4functional genomicstranscriptional regulationsequence analysisIt is nowadays accepted that eukaryotic complexity is not dictated by the number of protein-coding genes of the genome, but rather achieved through the combinatorics of gene expression programs. 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Distinct aspects of the expression pattern of a gene are mediated by discrete regulatory sequences, known as cis-regulatory elements. The work described in this thesis was aimed at developing computational and statistical methods to guide the search and characterization of novel cis-regulatory elements.20162016[xslt]Saxonrosdok/id00001799https://purl.uni-rostock.de/rosdok/id0000179987010401210.18453/rosdok_id00001799urn:nbn:de:gbv:28-diss2016-0113-4Leila Taher Dr.Taher Leila Dr.Unraveling the transcriptional Cis-regulatory codeDissertationdoctoral thesisUniversität Rostock, 2016It is nowadays accepted that eukaryotic complexity is not dictated by the number of protein-coding genes of the genome, but rather achieved through the combinatorics of gene expression programs. Distinct aspects of the expression pattern of a gene are mediated by discrete regulatory sequences, known…Dr. Leila TaherUnraveling the transcriptional Cis-regulatory codeUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001799111215731XDr.LeilaTaher1978-VerfasserInautProf. Dr.WojciechMakalowskiWestfälische Wilhelms-Universität Münster, Institut für BioinformatikAkademischeR BetreuerIndgsProf. Dr.BurkhardMorgensternGeorg-August-Universität Göttingen, Institut für Mikrobiologie und GenetikAkademischeR BetreuerIndgs140626085Prof. Dr.GeorgFüllenUniversitätsmedizin Rostock, Institut für Biostatistik und Informatik in Medizin und Alterns- forschungAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001799[purl]http://purl.uni-rostock.de/rosdok/id00001799[urn]urn:nbn:de:gbv:28-diss2016-0113-4open_access20162016epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.umrstate:published