mycoreobjectrosdok_disshab_0000001706rosdok_disshab_0000001706rosdokdisshabrosdok_derivate_00000368362023-08-08T10:07:49.006Z2017-04-11T08:32:05.597ZadministratoreditorDpublished1rosdok_derivate_0000036836truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00001884884550958MODS updated during RosDok migration in June 2021DissertationHochschulschrift1129883426Venkata Ajay NarendraTalabattula1982-VerfasserInautWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayen136256864MD PhDArndtRolfsUniversity of Rostock, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs1027954480MD PhDGabriele M.RuneUniversitätsklinikum Hamburg-Eppendorf, Institut für NeuroanatomieAkademischeR BetreuerIndgsPhDHugo MuruaEscobarUniversity of Rostock, Zentrum für Innere MedizinAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001884http://purl.uni-rostock.de/rosdok/id00001884urn:nbn:de:gbv:28-diss2017-0048-9610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2017monographic20172017Universitätsbibliothek RostockRostock20172017HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.Pyk2canonicalnoncanonicalUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001884doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Wnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwaygnd:1129883426gnd:136256864gnd:1027954480gnd:1029510660gnd:1129883426gnd:136256864gnd:1027954480gnd:1029510660rosdok_disshab_0000001706-d727430e39gnd:1129883426Venkata Ajay Narendra TalabattulaVenkata Ajay Narendra Talabattularosdok_disshab_0000001706-d727430e60gnd:136256864MD PhD Arndt RolfsMD PhD Arndt Rolfsrosdok_disshab_0000001706-d727430e75gnd:1027954480MD PhD Gabriele M. RuneMD PhD Gabriele M. Runerosdok_disshab_0000001706-d727430e90PhD Hugo Murua EscobarPhD Hugo Murua Escobarrosdok_disshab_0000001706-d727430e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaMD PhD Arndt RolfsMD PhD Gabriele M. RunePhD Hugo Murua EscobarUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaMD PhD Arndt RolfsMD PhD Gabriele M. RunePhD Hugo Murua EscobarUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001884http://purl.uni-rostock.de/rosdok/id00001884urn:nbn:de:gbv:28-diss2017-0048-9Pyk2canonicalnoncanonicalHumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.20172017epub.dissertation1 Dissertation_Talabattula_2017.pdf 2621024 0525124656e33f08d1a8f912b8ee46c8 rosdok/id00001884884550958MODS updated during RosDok migration in June 2021DissertationHochschulschrift1129883426Venkata Ajay NarendraTalabattula1982-VerfasserInautWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayen136256864MD PhDArndtRolfsUniversity of Rostock, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs1027954480MD PhDGabriele M.RuneUniversitätsklinikum Hamburg-Eppendorf, Institut für NeuroanatomieAkademischeR BetreuerIndgsPhDHugo MuruaEscobarUniversity of Rostock, Zentrum für Innere MedizinAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00001884http://purl.uni-rostock.de/rosdok/id00001884urn:nbn:de:gbv:28-diss2017-0048-9610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2017monographic20172017Universitätsbibliothek RostockRostock20172017HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.Pyk2canonicalnoncanonicalUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00001884 2017-04-11T08:32:05.597Z 2023-08-08T10:07:49.006Z 2023-08-18T10:07:49.010Z editorD {"identifier":"rosdok/id00001884","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:28:33.631Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00001884","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:28:33.819Z","registered":"2018-06-30T13:28:33.819Z"} {"identifier":"10.18453/rosdok_id00001884","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:28:35.074Z","registered":"2018-06-30T13:28:35.074Z"} {"identifier":"urn:nbn:de:gbv:28-diss2017-0048-9","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:28:33.638Z","registered":"2017-04-19T02:26:06.997Z"} administratorfulltextfile/rosdok_disshab_0000001706/rosdok_derivate_0000036836/Dissertation_Talabattula_2017.pdfWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwaygnd:1129883426gnd:136256864gnd:1027954480gnd:1029510660gnd:1129883426gnd:136256864gnd:1027954480gnd:1029510660rosdok_disshab_0000001706-d727430e39gnd:1129883426Venkata Ajay Narendra TalabattulaVenkata Ajay Narendra Talabattularosdok_disshab_0000001706-d727430e60gnd:136256864MD PhD Arndt RolfsMD PhD Arndt Rolfsrosdok_disshab_0000001706-d727430e75gnd:1027954480MD PhD Gabriele M. RuneMD PhD Gabriele M. Runerosdok_disshab_0000001706-d727430e90PhD Hugo Murua EscobarPhD Hugo Murua Escobarrosdok_disshab_0000001706-d727430e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaMD PhD Arndt RolfsMD PhD Gabriele M. RunePhD Hugo Murua EscobarUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaMD PhD Arndt RolfsMD PhD Gabriele M. RunePhD Hugo Murua EscobarUniversität Rostock UniversitätsmedizinVenkata Ajay Narendra TalabattulaRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00001884http://purl.uni-rostock.de/rosdok/id00001884urn:nbn:de:gbv:28-diss2017-0048-9Pyk2canonicalnoncanonicalHumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+ target genes CaMKII and Pyk2 in the differentiating VM cells. The results demonstrated that Pyk2 decreases GSK3β activity and stabilizes β-catenin, suggesting there is an intercross between Wnt/β-catenin and Wnt/Ca2+-pathway via Pyk2.20172017[xslt]Saxonrosdok/id00001884https://purl.uni-rostock.de/rosdok/id0000188488455095810.18453/rosdok_id00001884urn:nbn:de:gbv:28-diss2017-0048-9Venkata Ajay Narendra TalabattulaTalabattula Venkata Ajay NarendraWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayDissertationdoctoral thesisUniversität Rostock, 2017HumanNPCs (hNPCs) are the suitable cell source in translation medicine for neurodegenerative disease. In the present study, effects of Wnt3a on the differentiation of hNPC were studied. The results showed that Wnt3a induces canonical and non canonical Wnt pathways. Furthermore, Wnt3a increases Ca2+…Venkata Ajay Narendra TalabattulaWnt3a induces neuronal differentiation and crosstalk between Wnt/Ca2+-pathway and Wnt/β-catenin pathwayUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000018841129883426Venkata Ajay NarendraTalabattula1982-VerfasserInaut136256864MD PhDArndtRolfsUniversity of Rostock, Albrecht Kossel Institut für NeuroregenerationAkademischeR BetreuerIndgs1027954480MD PhDGabriele M.RuneUniversitätsklinikum Hamburg-Eppendorf, Institut für NeuroanatomieAkademischeR BetreuerIndgsPhDHugo MuruaEscobarUniversity of Rostock, Zentrum für Innere MedizinAkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00001884[purl]http://purl.uni-rostock.de/rosdok/id00001884[urn]urn:nbn:de:gbv:28-diss2017-0048-9open_access20172017epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.umrstate:published