mycoreobjectrosdok_disshab_0000001826rosdok_disshab_0000001826rosdokdisshabrosdok_derivate_00000381412023-08-08T10:08:29.622Z2017-12-20T09:50:47.581ZadministratoreditorDpublished1rosdok_derivate_0000038141truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000020041009595563MODS updated during RosDok migration in June 2021DissertationHochschulschrift1149269332JohannaPügge1992-VerfasserInautAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationen136319564Prof. Dr. med.BrigitteVollmarUniversitätsmedizin Rostock, Institut für Experimentelle ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.HenrikThorlaciusLund University, Department of Clinical Science, Surgery Research UnitAkademischeR BetreuerIndgs136455107Prof. Dr. med.ErnstKlarUniversitätsmedizin Rostock, Abteilung für Allgemeine, Thorax-, Gefäß-, und Transplantationschirurgie,AkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00002004http://purl.uni-rostock.de/rosdok/id00002004urn:nbn:de:gbv:28-diss2017-0168-6610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2017monographic20172017Universitätsbibliothek RostockRostock20172017Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. 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Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.selectinintegrininflammationhistone type 3Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002004doctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisrfc5646:enrfc5646:enEnglischEnglishengengSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2licenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/Adhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationgnd:1149269332gnd:136319564gnd:136455107gnd:1029510660gnd:1149269332gnd:136319564gnd:136455107gnd:1029510660rosdok_disshab_0000001826-d505390e39gnd:1149269332Johanna PüggeJohanna Püggerosdok_disshab_0000001826-d505390e60gnd:136319564Prof. Dr. med. Brigitte VollmarProf. Dr. med. Brigitte Vollmarrosdok_disshab_0000001826-d505390e75Prof. Dr. med. Henrik ThorlaciusProf. Dr. med. Henrik Thorlaciusrosdok_disshab_0000001826-d505390e88gnd:136455107Prof. Dr. med. Ernst KlarProf. Dr. med. Ernst Klarrosdok_disshab_0000001826-d505390e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinJohanna PüggeProf. Dr. med. Brigitte VollmarProf. Dr. med. Henrik ThorlaciusProf. Dr. med. Ernst KlarUniversität Rostock UniversitätsmedizinJohanna PüggeProf. Dr. med. Brigitte VollmarProf. Dr. med. Henrik ThorlaciusProf. Dr. med. Ernst KlarUniversität Rostock UniversitätsmedizinJohanna PüggeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00002004http://purl.uni-rostock.de/rosdok/id00002004urn:nbn:de:gbv:28-diss2017-0168-6selectinintegrininflammationhistone type 3Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.20172017epub.dissertation1 Dissertation_Puegge_2017.pdf 2453910 9fd543f47f051feb0de63fdf2d41c2f4 rosdok/id000020041009595563MODS updated during RosDok migration in June 2021DissertationHochschulschrift1149269332JohannaPügge1992-VerfasserInautAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationen136319564Prof. Dr. med.BrigitteVollmarUniversitätsmedizin Rostock, Institut für Experimentelle ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.HenrikThorlaciusLund University, Department of Clinical Science, Surgery Research UnitAkademischeR BetreuerIndgs136455107Prof. Dr. med.ErnstKlarUniversitätsmedizin Rostock, Abteilung für Allgemeine, Thorax-, Gefäß-, und Transplantationschirurgie,AkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg10.18453/rosdok_id00002004http://purl.uni-rostock.de/rosdok/id00002004urn:nbn:de:gbv:28-diss2017-0168-6610 Medizin, GesundheitUniversitätsmedizinfrei zugänglich (Open Access)Lizenz Metadaten: CC0Nutzungsrechte erteiltalle Rechte vorbehaltenUniversität RostockRostock2017monographic20172017Universitätsbibliothek RostockRostock20172017Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.selectinintegrininflammationhistone type 3Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002004 2017-12-20T09:50:47.581Z 2023-08-08T10:08:29.622Z 2023-08-18T10:08:29.627Z editorD {"identifier":"rosdok/id00002004","type":"local_id","additional":"","service":"MCRLocalID","created":"2018-06-30T13:32:58.987Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00002004","type":"purl","additional":"","service":"RosDokPURL","created":"2018-06-30T13:32:59.188Z","registered":"2018-06-30T13:32:59.188Z"} {"identifier":"10.18453/rosdok_id00002004","type":"doi","additional":"","service":"RosDokDOI","created":"2018-06-30T13:33:00.488Z","registered":"2018-06-30T13:33:00.488Z"} {"identifier":"urn:nbn:de:gbv:28-diss2017-0168-6","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2018-06-30T13:32:58.995Z","registered":"2017-12-22T03:13:10.443Z"} administratorfulltextfile/rosdok_disshab_0000001826/rosdok_derivate_0000038141/Dissertation_Puegge_2017.pdfAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationgnd:1149269332gnd:136319564gnd:136455107gnd:1029510660gnd:1149269332gnd:136319564gnd:136455107gnd:1029510660rosdok_disshab_0000001826-d505390e39gnd:1149269332Johanna PüggeJohanna Püggerosdok_disshab_0000001826-d505390e60gnd:136319564Prof. Dr. med. Brigitte VollmarProf. Dr. med. Brigitte Vollmarrosdok_disshab_0000001826-d505390e75Prof. Dr. med. Henrik ThorlaciusProf. Dr. med. Henrik Thorlaciusrosdok_disshab_0000001826-d505390e88gnd:136455107Prof. Dr. med. Ernst KlarProf. Dr. med. Ernst Klarrosdok_disshab_0000001826-d505390e104gnd:1029510660Universität Rostock UniversitätsmedizinUniversität Rostock UniversitätsmedizinJohanna PüggeProf. Dr. med. Brigitte VollmarProf. Dr. med. Henrik ThorlaciusProf. Dr. med. Ernst KlarUniversität Rostock UniversitätsmedizinJohanna PüggeProf. Dr. med. Brigitte VollmarProf. Dr. med. Henrik ThorlaciusProf. Dr. med. Ernst KlarUniversität Rostock UniversitätsmedizinJohanna PüggeRostockUniversität Rostockepub.dissertation10.18453/rosdok_id00002004http://purl.uni-rostock.de/rosdok/id00002004urn:nbn:de:gbv:28-diss2017-0168-6selectinintegrininflammationhistone type 3Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic administration of monoclonal antibodies. Extracellular histones 3 induced leukocyte recruitment in a dose-dependent manner. Histone-induced neutrophil rolling is predominately mediated by P-selectin/PSGL-1 interactions, whereas histone-induced leukocyte adhesion is inter alia mediated by Mac-1 and LFA-1.20172017[xslt]Saxonrosdok/id00002004https://purl.uni-rostock.de/rosdok/id00002004100959556310.18453/rosdok_id00002004urn:nbn:de:gbv:28-diss2017-0168-6Johanna PüggePügge JohannaAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationDissertationdoctoral thesisUniversität Rostock, 2017Intravital microscopy of the mouse cremaster microcirculation was used to examine the role of specific adhesion molecules in histone-dependent leukocyte recruitment. Histones type 3 were given locally to the cremaster muscle sack and specific adhesion molecules were blocked by systemic…Johanna PüggeAdhesive mechanisms of histone-induced neutrophil-endothelium interactions in the muscle microcirculationUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id000020041149269332JohannaPügge1992-VerfasserInaut136319564Prof. Dr. med.BrigitteVollmarUniversitätsmedizin Rostock, Institut für Experimentelle ChirurgieAkademischeR BetreuerIndgsProf. Dr. med.HenrikThorlaciusLund University, Department of Clinical Science, Surgery Research UnitAkademischeR BetreuerIndgs136455107Prof. Dr. med.ErnstKlarUniversitätsmedizin Rostock, Abteilung für Allgemeine, Thorax-, Gefäß-, und Transplantationschirurgie,AkademischeR BetreuerIndgs1029510660Universität RostockUniversitätsmedizinGrad-verleihende Institutiondgg[doi]10.18453/rosdok_id00002004[purl]http://purl.uni-rostock.de/rosdok/id00002004[urn]urn:nbn:de:gbv:28-diss2017-0168-6open_access20172017epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:610institution:unirostock.umrstate:published