Synthesis of novel quinolines, pyrrolo[2,3-b]indoles, and 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-diones via palladium-catalyzed cross-coupling reactions

10.18453/rosdok_id00002414 Cherevatenko, Maksym Maksym Cherevatenko http://d-nb.info/gnd/1154322130 Synthesis of novel quinolines, pyrrolo[2,3-b]indoles, and 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-diones via palladium-catalyzed cross-coupling reactions Universität Rostock 2017 540 Chemistry & allied sciences 2017 en http://purl.uni-rostock.de/rosdok/id00002414 urn:nbn:de:gbv:28-rosdok_id00002414-0 The present thesis is mainly dedicated to the study of the synthesis of quinolines, pyrolo[2,3-b]indoles and 1H-pyrimido[4,5-b]indole-2,4(3H,9H)-diones via palladium-catalyzed cross-coupling reactions. This includes arylation of quinolines via Suzuki-Miyaura and alkynylation of 4-trifluoromethylquinolines via Sonogashira reaction. Consequent synthesis of a wide range of fused pyridines and their further modifications were successfully performed. A number of pyrolo[2,3-b]indoles and pyrimido[4,5-b]indole-2,4(3H,9H)-diones were synthesized with the usage of Buchwald-Hartwig reaction.