mycoreobjectrosdok_disshab_0000002146rosdok_disshab_0000002146rosdokdisshabrosdok_derivate_00000683122023-08-08T10:10:21.315Z2019-07-24T10:44:07.474ZadministratoreditorDpublished1rosdok_derivate_0000068312truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000025031669963233Oau2019-07-242023-08-05T19:12:59ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsIn this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.AndreaLiedmann1979 -VerfasserInaut1191293580ArndtRolfs1959 -AkademischeR BetreuerIndgs136256864Sergei A.KuznetsovAkademischeR BetreuerIndgsAndreasWree1952 -AkademischeR BetreuerIndgs13664328038329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002503urn:nbn:de:gbv:28-rosdok_id00002503-310.18453/rosdok_id00002503570 Biowissenschaften, Biologie610 Medizin, GesundheitMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2013Universität RostockRostockmonographic201320132019Universitätsbibliothek RostockRostock2019Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002503Arndt Rolfs (Universität Rostock, Albrecht-Kossel-Institut für Neuroregeneration (AKos), Zentrum für Nervenheilkunde) ; Sergei A. Kuznetsov (Institut für Zellbiologie und Biosystemtechnik, Fachbereich Biowissenschaften) ; A. Wree (Universitätsmedizin Rostock, Institut für Anatomie)vorgelegt von Andrea LiedmannWW 3880WX 6640MenschVorläuferzelleNervenstammzelledoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsgnd:1191293580gnd:136256864gnd:136643280gnd:38329-6gnd:2147083-2gnd:1191293580gnd:136256864gnd:136643280gnd:38329-6gnd:2147083-2rosdok_disshab_0000002146-d537452e52gnd:1191293580Andrea LiedmannAndrea Liedmannrosdok_disshab_0000002146-d537452e66gnd:136256864Arndt RolfsArndt Rolfsrosdok_disshab_0000002146-d537452e80Sergei A. KuznetsovSergei A. Kuznetsovrosdok_disshab_0000002146-d537452e90gnd:136643280Andreas WreeAndreas Wreerosdok_disshab_0000002146-d537452e105gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002146-d537452e116gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannArndt RolfsSergei A. KuznetsovAndreas WreeUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannArndt RolfsSergei A. KuznetsovAndreas WreeUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002503urn:nbn:de:gbv:28-rosdok_id00002503-310.18453/rosdok_id00002503WW 3880WX 6640MenschVorläuferzelleNervenstammzelleIn this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.20132013Arndt Rolfs (Universität Rostock, Albrecht-Kossel-Institut für Neuroregeneration (AKos), Zentrum für Nervenheilkunde) ; Sergei A. Kuznetsov (Institut für Zellbiologie und Biosystemtechnik, Fachbereich Biowissenschaften) ; A. Wree (Universitätsmedizin Rostock, Institut für Anatomie)vorgelegt von Andrea Liedmannepub.dissertation1 Liedmann_Dissertation_2019.pdf 13516786 ca9a74c68f2dd5769933da376af81894 rosdok/id000025031669963233Oau2019-07-242023-08-05T19:12:59ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsIn this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. 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Kuznetsov (Institut für Zellbiologie und Biosystemtechnik, Fachbereich Biowissenschaften) ; A. Wree (Universitätsmedizin Rostock, Institut für Anatomie)vorgelegt von Andrea LiedmannWW 3880WX 6640MenschVorläuferzelleNervenstammzelle 2019-07-24T10:44:07.474Z 2023-08-08T10:10:21.315Z 2023-08-18T10:10:21.325Z {"identifier":"rosdok/id00002503","type":"local_id","additional":"","service":"MCRLocalID","created":"2019-07-24T10:44:07.605Z"} editorD {"identifier":"http://purl.uni-rostock.de/rosdok/id00002503","type":"purl","additional":"","service":"RosDokPURL","created":"2019-07-24T10:56:42.278Z","registered":"2019-07-24T10:56:42.278Z"} {"identifier":"10.18453/rosdok_id00002503","type":"doi","additional":"","service":"RosDokDOI","created":"2019-07-24T10:56:45.387Z","registered":"2019-07-24T10:56:45.387Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00002503-3","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2019-07-24T10:44:07.668Z","registered":"2019-07-25T02:29:12.090Z"} administratorfulltextfile/rosdok_disshab_0000002146/rosdok_derivate_0000068312/Liedmann_Dissertation_2019.pdfDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsgnd:1191293580gnd:136256864gnd:136643280gnd:38329-6gnd:2147083-2gnd:1191293580gnd:136256864gnd:136643280gnd:38329-6gnd:2147083-2rosdok_disshab_0000002146-d537452e52gnd:1191293580Andrea LiedmannAndrea Liedmannrosdok_disshab_0000002146-d537452e66gnd:136256864Arndt RolfsArndt Rolfsrosdok_disshab_0000002146-d537452e80Sergei A. KuznetsovSergei A. Kuznetsovrosdok_disshab_0000002146-d537452e90gnd:136643280Andreas WreeAndreas Wreerosdok_disshab_0000002146-d537452e105gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002146-d537452e116gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannArndt RolfsSergei A. KuznetsovAndreas WreeUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannArndt RolfsSergei A. KuznetsovAndreas WreeUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätAndrea LiedmannRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002503urn:nbn:de:gbv:28-rosdok_id00002503-310.18453/rosdok_id00002503WW 3880WX 6640MenschVorläuferzelleNervenstammzelleIn this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and survival of the cells. The hydrogels enhance the neuronal differentiation of the hNPCs of about 2.3 fold, with an additional increase of about 2,5 fold more for the modified Scaffolds. Additionally the hNPCs were protected from apoptosis and accordingly survived longer when encapsulated in 3D scaffolds.20132013Arndt Rolfs (Universität Rostock, Albrecht-Kossel-Institut für Neuroregeneration (AKos), Zentrum für Nervenheilkunde) ; Sergei A. Kuznetsov (Institut für Zellbiologie und Biosystemtechnik, Fachbereich Biowissenschaften) ; A. Wree (Universitätsmedizin Rostock, Institut für Anatomie)vorgelegt von Andrea Liedmann[xslt]Saxonrosdok/id00002503https://purl.uni-rostock.de/rosdok/id00002503166996323310.18453/rosdok_id00002503urn:nbn:de:gbv:28-rosdok_id00002503-3Andrea LiedmannLiedmann AndreaDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsDissertationdoctoral thesisUniversität Rostock, 2013In this project we used a human neural progenitor cell line (hNPCs), whereat the cells were embedded in the synthetic self-assembling peptide hydrogel and modified formulations. Different protocols of culture conditions (2D versus 3D) were compared to analyze the neuronal differentiation and…Andrea LiedmannDifferentiation and survival of human neural progenitor cells in 3D scaffolds of self-assembling peptide hydrogelsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002503AndreaLiedmann1979 -VerfasserInaut1191293580ArndtRolfs1959 -AkademischeR BetreuerIndgs136256864Sergei A.KuznetsovAkademischeR BetreuerIndgsAndreasWree1952 -AkademischeR BetreuerIndgs13664328038329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002503[urn]urn:nbn:de:gbv:28-rosdok_id00002503-3[doi]10.18453/rosdok_id00002503open_access20132013epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570SDNB:610institution:unirostock.mnfstate:published