10.18453/rosdok_id00002513 Perdomo Rivera, Rodisnel Rodisnel Perdomo Rivera http://d-nb.info/gnd/1162368152 Universität Rostock 2018 540 Chemistry & allied sciences 2018 en http://purl.uni-rostock.de/rosdok/id00002513 urn:nbn:de:gbv:28-rosdok_id00002513-0 This thesis deals with the functionalization of pentahalogenated pyridines and dihalogenated quinolines through palladium catalyzed cross coupling reactions. This includes the chemo-selective arylation and alkynylation of 4-bromo-2,3,5-trichloro-6-iodopyridine using Suzuki and Sonogashira reactions. The chemo-selective arylation of 4,6-dihalogenated-2-(trifluoromethyl)quinoline by Suzuki reaction was studied. Besides, the synthesis of indolo [2,3-c]quinolines was studied by sequential chemo-selective Suzuki reaction followed by double C-N coupling starting from 3-bromo-4-iodoquinoline.