mycoreobjectrosdok_disshab_0000002165rosdok_disshab_0000002165rosdokdisshabrosdok_derivate_00000685042023-08-08T10:10:28.043Z2019-08-21T10:07:01.186ZadministratoreditorDpublished1rosdok_derivate_0000068504truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id00002522167175865XOau2019-08-212023-08-05T19:13:12ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.MargitSchwartz1986 -VerfasserInaut1193142997BurkhardHinz1967 -AkademischeR BetreuerIndgs136257240BernhardRauchAkademischeR BetreuerIndgsKarinKraft1952 -AkademischeR BetreuerIndgs13605185538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002522urn:nbn:de:gbv:28-rosdok_id00002522-010.18453/rosdok_id00002522570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinCC BY-NC-ND 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2018Universität RostockRostockmonographic201920182019Universitätsbibliothek RostockRostock2019Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002522Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)vorgelegt von Margit SchwartzXI 5104GefäßmuskulaturMuskelzelleCannabinoideHämoxygenasedoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.cclicenselicenseinfo:work.cclicenseCC-LizenzCC-licenselicenseinfo:work.cclicense.cc-by-nc-ndlicenseinfo:work.cclicense.cc-by-nc-ndCC BY-NC-NDCC BY-NC-NDlicenseinfo:work.cclicense.cc-by-nc-nd.v40licenseinfo:work.cclicense.cc-by-nc-nd.v40CC BY-NC-ND 4.0CC BY-NC-ND 4.0/creativecommons/l/by-nc-nd/4.0/88x31.png[DE-28]Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International$cCC BY-NC-ND 4.0$gCreative Commons$uhttps://creativecommons.org/licenses/by-nc-nd/4.0/https://creativecommons.org/licenses/by-nc-nd/4.0/https://creativecommons.org/licenses/by-nc-nd/4.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1gnd:1193142997gnd:136257240gnd:136051855gnd:38329-6gnd:1029510660gnd:1193142997gnd:136257240gnd:136051855gnd:38329-6gnd:1029510660rosdok_disshab_0000002165-d453656e53gnd:1193142997Margit SchwartzMargit Schwartzrosdok_disshab_0000002165-d453656e67gnd:136257240Burkhard HinzBurkhard Hinzrosdok_disshab_0000002165-d453656e81Bernhard RauchBernhard Rauchrosdok_disshab_0000002165-d453656e91gnd:136051855Karin KraftKarin Kraftrosdok_disshab_0000002165-d453656e106gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002165-d453656e117gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockMargit SchwartzBurkhard HinzBernhard RauchKarin KraftUniversität RostockUniversitätsmedizin RostockMargit SchwartzBurkhard HinzBernhard RauchKarin KraftUniversität RostockUniversitätsmedizin RostockMargit SchwartzRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002522urn:nbn:de:gbv:28-rosdok_id00002522-010.18453/rosdok_id00002522XI 5104GefäßmuskulaturMuskelzelleCannabinoideHämoxygenaseExcessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.20182018Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)vorgelegt von Margit Schwartzepub.dissertation1 Schwartz_Dissertation_2019.pdf 8679205 f1e93896ab374acca84a7759ea96be69 rosdok/id00002522167175865XOau2019-08-212023-08-05T19:13:12ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.MargitSchwartz1986 -VerfasserInaut1193142997BurkhardHinz1967 -AkademischeR BetreuerIndgs136257240BernhardRauchAkademischeR BetreuerIndgsKarinKraft1952 -AkademischeR BetreuerIndgs13605185538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002522urn:nbn:de:gbv:28-rosdok_id00002522-010.18453/rosdok_id00002522570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinCC BY-NC-ND 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2018Universität RostockRostockmonographic201920182019Universitätsbibliothek RostockRostock2019Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002522Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)vorgelegt von Margit SchwartzXI 5104GefäßmuskulaturMuskelzelleCannabinoideHämoxygenase 2019-08-21T10:07:01.186Z 2023-08-08T10:10:28.043Z 2023-08-18T10:10:28.048Z {"identifier":"rosdok/id00002522","type":"local_id","additional":"","service":"MCRLocalID","created":"2019-08-21T10:07:05.644Z"} editorD {"identifier":"http://purl.uni-rostock.de/rosdok/id00002522","type":"purl","additional":"","service":"RosDokPURL","created":"2019-08-21T10:21:55.887Z","registered":"2019-08-21T10:21:55.887Z"} {"identifier":"10.18453/rosdok_id00002522","type":"doi","additional":"","service":"RosDokDOI","created":"2019-08-21T10:21:57.314Z","registered":"2019-08-21T10:21:57.314Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00002522-0","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2019-08-21T10:07:05.717Z","registered":"2019-08-22T02:29:25.103Z"} administratorfulltextfile/rosdok_disshab_0000002165/rosdok_derivate_0000068504/Schwartz_Dissertation_2019.pdfEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1Effect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1gnd:1193142997gnd:136257240gnd:136051855gnd:38329-6gnd:1029510660gnd:1193142997gnd:136257240gnd:136051855gnd:38329-6gnd:1029510660rosdok_disshab_0000002165-d453656e53gnd:1193142997Margit SchwartzMargit Schwartzrosdok_disshab_0000002165-d453656e67gnd:136257240Burkhard HinzBurkhard Hinzrosdok_disshab_0000002165-d453656e81Bernhard RauchBernhard Rauchrosdok_disshab_0000002165-d453656e91gnd:136051855Karin KraftKarin Kraftrosdok_disshab_0000002165-d453656e106gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002165-d453656e117gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockMargit SchwartzBurkhard HinzBernhard RauchKarin KraftUniversität RostockUniversitätsmedizin RostockMargit SchwartzBurkhard HinzBernhard RauchKarin KraftUniversität RostockUniversitätsmedizin RostockMargit SchwartzRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002522urn:nbn:de:gbv:28-rosdok_id00002522-010.18453/rosdok_id00002522XI 5104GefäßmuskulaturMuskelzelleCannabinoideHämoxygenaseExcessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD in an ROS-depentent manner. In addition, inhibition of proliferation and migration of VSMC were observed and not attenuated by inhibition/knockdown of HO-1. This work provides evidence of a CBD-mediated induction of HO-1 in VSMC and potential protective effects via an HO-1-independent mechanism.20182018Burkhard Hinz (Universitätsmedizin Rostock, Institut für Pharmakologie und Toxikologie) ; Bernhard Rauch (Universitätsmedizin Greifswald, Institut für Pharmakologie, Abt. Allg. Pharmakologie) ; Karin Kraft (Universitätsmedizin Rostock, Zentrum für Innnere Medizin, Lehrstuhl für Naturheilkunde)vorgelegt von Margit Schwartz[xslt]Saxonrosdok/id00002522https://purl.uni-rostock.de/rosdok/id00002522167175865X10.18453/rosdok_id00002522urn:nbn:de:gbv:28-rosdok_id00002522-0Margit SchwartzSchwartz MargitEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cells : role of the anti-oxidative enzyme heme oxygenase-1Dissertationdoctoral thesisUniversität Rostock, 2018Excessive proliferation and migration of VSMC are closely linked to cardiovascular diseases and cancer. The enzyme HO-1 was shown to be involved in anti-proliferative/anti-migratory effects in VSMC. This thesis investigates the effect of CBD on VSMC and HO-1. HO-1 was significantly increased by CBD…Margit SchwartzEffect of cannabidiol on disease-associated functions of human vascular smooth muscle cellsrole of the anti-oxidative enzyme heme oxygenase-1Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002522MargitSchwartz1986 -VerfasserInaut1193142997BurkhardHinz1967 -AkademischeR BetreuerIndgs136257240BernhardRauchAkademischeR BetreuerIndgsKarinKraft1952 -AkademischeR BetreuerIndgs13605185538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002522[urn]urn:nbn:de:gbv:28-rosdok_id00002522-0[doi]10.18453/rosdok_id00002522open_access20182018epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570SDNB:610institution:unirostock.umrstate:published