mycoreobjectrosdok_disshab_0000002188rosdok_disshab_0000002188rosdokdisshabrosdok_derivate_00000816182025-10-14T13:33:50.699Z2019-11-25T09:09:05.194ZeditorKEeditorDpublished1rosdok_derivate_0000081618truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000025541683331141Oau2019-11-252023-08-05T19:13:30ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftAnintegrative workflow to study large-scale biochemical networksI propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.Faiz MuhammadKhan1985 -VerfasserInaut1200360885OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937JanHasenauerAkademischeR BetreuerIndgs10378102950000-0002-4935-3312GeorgFüllen1967 -AkademischeR BetreuerIndgs14062608538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg10085032-7Universität RostockFakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002554urn:nbn:de:gbv:28-rosdok_id00002554-310.18453/rosdok_id00002554004 InformatikFakultät für Informatik und Elektrotechnikalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2019Universität RostockRostockmonographic201920192019Universitätsbibliothek RostockRostock2019Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002554Olaf Wolkenhauer (University of Rostock) ; Jan Hasenauer (University of Bonn) ; Georg Füllen (University of Rostock)vorgelegt von Faiz KhanWC 7700BiochemieProzesskettedoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:004SDNB:004004 Informatik004 Data processing Computer sciencesinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.iefinstitution:unirostock.iefFakultät für Informatik und ElektrotechnikFaculty of Computer Science and Electrical EngineeringUniversität Rostock. Fakultät für Informatik und ElektrotechnikFakultät für Informatik<br />und ElektrotechnikUni.Rostock.Fakultaet.IEFhttp://d-nb.info/gnd/10085032-7licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengAnintegrative workflow to study large-scale biochemical networksAn integrative workflow to study large-scale biochemical networksgnd:1200360885gnd:133515931orcid:0000-0001-6105-2937gnd:1037810295orcid:0000-0002-4935-3312gnd:140626085gnd:38329-6gnd:10085032-7gnd:1200360885gnd:133515931orcid:0000-0001-6105-2937gnd:1037810295orcid:0000-0002-4935-3312gnd:140626085gnd:38329-6gnd:10085032-7rosdok_disshab_0000002188-d2403454e53gnd:1200360885Faiz Muhammad KhanFaiz Muhammad Khanrosdok_disshab_0000002188-d2403454e67gnd:133515931orcid:0000-0001-6105-2937Olaf WolkenhauerOlaf Wolkenhauerrosdok_disshab_0000002188-d2403454e83gnd:1037810295orcid:0000-0002-4935-3312Jan HasenauerJan Hasenauerrosdok_disshab_0000002188-d2403454e97gnd:140626085Georg FüllenGeorg Füllenrosdok_disshab_0000002188-d2403454e112gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002188-d2403454e123gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanOlaf WolkenhauerJan HasenauerGeorg FüllenUniversität RostockUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanOlaf WolkenhauerJan HasenauerGeorg FüllenUniversität RostockUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002554urn:nbn:de:gbv:28-rosdok_id00002554-310.18453/rosdok_id00002554WC 7700BiochemieProzessketteI propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.20192019Olaf Wolkenhauer (University of Rostock) ; Jan Hasenauer (University of Bonn) ; Georg Füllen (University of Rostock)vorgelegt von Faiz Khanepub.dissertation1 Khan_Dissertation_2019.pdf 25471476 58423337066b72ef2d41bea8f25185f9 rosdok/id000025541683331141Oau2019-11-252023-08-05T19:13:30ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftAnintegrative workflow to study large-scale biochemical networksI propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.Faiz MuhammadKhan1985 -VerfasserInaut1200360885OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937JanHasenauerAkademischeR BetreuerIndgs10378102950000-0002-4935-3312GeorgFüllen1967 -AkademischeR BetreuerIndgs14062608538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg10085032-7Universität RostockFakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002554urn:nbn:de:gbv:28-rosdok_id00002554-310.18453/rosdok_id00002554004 InformatikFakultät für Informatik und Elektrotechnikalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2019Universität RostockRostockmonographic201920192019Universitätsbibliothek RostockRostock2019Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002554Olaf Wolkenhauer (University of Rostock) ; Jan Hasenauer (University of Bonn) ; Georg Füllen (University of Rostock)vorgelegt von Faiz KhanWC 7700BiochemieProzesskette 2019-11-25T09:09:05.194Z 2025-10-14T13:33:50.699Z 2025-10-24T13:33:50.713Z {"identifier":"rosdok/id00002554","type":"local_id","additional":"","service":"MCRLocalID","created":"2019-11-25T09:09:05.270Z"} editorD {"identifier":"http://purl.uni-rostock.de/rosdok/id00002554","type":"purl","additional":"","service":"RosDokPURL","created":"2019-11-25T09:16:19.912Z","registered":"2019-11-25T09:16:19.912Z"} {"identifier":"10.18453/rosdok_id00002554","type":"doi","additional":"","service":"RosDokDOI","created":"2019-11-25T09:16:21.146Z","registered":"2019-11-25T09:16:21.146Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00002554-3","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2019-11-25T09:09:05.326Z","registered":"2019-11-26T03:26:26.003Z"} editorKEfulltextfile/rosdok_disshab_0000002188/rosdok_derivate_0000081618/Khan_Dissertation_2019.pdfAnintegrative workflow to study large-scale biochemical networksAn integrative workflow to study large-scale biochemical networksgnd:1200360885gnd:133515931orcid:0000-0001-6105-2937gnd:1037810295orcid:0000-0002-4935-3312gnd:140626085gnd:38329-6gnd:10085032-7gnd:1200360885gnd:133515931orcid:0000-0001-6105-2937gnd:1037810295orcid:0000-0002-4935-3312gnd:140626085gnd:38329-6gnd:10085032-7rosdok_disshab_0000002188-d2403454e53gnd:1200360885Faiz Muhammad KhanFaiz Muhammad Khanrosdok_disshab_0000002188-d2403454e67gnd:133515931orcid:0000-0001-6105-2937Olaf WolkenhauerOlaf Wolkenhauerrosdok_disshab_0000002188-d2403454e83gnd:1037810295orcid:0000-0002-4935-3312Jan HasenauerJan Hasenauerrosdok_disshab_0000002188-d2403454e97gnd:140626085Georg FüllenGeorg Füllenrosdok_disshab_0000002188-d2403454e112gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002188-d2403454e123gnd:10085032-7Universität Rostock Fakultät für Informatik und ElektrotechnikUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanOlaf WolkenhauerJan HasenauerGeorg FüllenUniversität RostockUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanOlaf WolkenhauerJan HasenauerGeorg FüllenUniversität RostockUniversität Rostock Fakultät für Informatik und ElektrotechnikFaiz Muhammad KhanRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002554urn:nbn:de:gbv:28-rosdok_id00002554-310.18453/rosdok_id00002554WC 7700BiochemieProzessketteI propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and detected disease signatures and drug targets, which were experimentally validated. Further, I developed a hybrid modeling framework that combines ODE- with logical-models to analyze the dynamics of large-scale non-linear systems. This thesis is a contribution to interdisciplinary cancer research.20192019Olaf Wolkenhauer (University of Rostock) ; Jan Hasenauer (University of Bonn) ; Georg Füllen (University of Rostock)vorgelegt von Faiz Khan[xslt]Saxonrosdok/id00002554https://purl.uni-rostock.de/rosdok/id00002554168333114110.18453/rosdok_id00002554urn:nbn:de:gbv:28-rosdok_id00002554-3Faiz Muhammad KhanKhan Faiz MuhammadAn integrative workflow to study large-scale biochemical networksDissertationdoctoral thesisUniversität Rostock, 2019I propose an integrative workflow to study large-scale biochemical networks by combining omics data, network structure and dynamical analysis to unravel disease mechanisms. Using the workflow, I identified core regulatory networks from the E2F1 network underlying EMT in bladder and breast cancer and…Faiz Muhammad KhanAnintegrative workflow to study large-scale biochemical networksUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002554Faiz MuhammadKhan1985 -VerfasserInaut1200360885OlafWolkenhauer1966 -AkademischeR BetreuerIndgs1335159310000-0001-6105-2937JanHasenauerAkademischeR BetreuerIndgs10378102950000-0002-4935-3312GeorgFüllen1967 -AkademischeR BetreuerIndgs14062608538329-6Universität Rostock1419 -Grad-verleihende Institutiondgg10085032-7Universität RostockFakultät für Informatik und Elektrotechnik2004 -Grad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002554[urn]urn:nbn:de:gbv:28-rosdok_id00002554-3[doi]10.18453/rosdok_id00002554open_access20192019epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:004institution:unirostock.iefstate:published