mycoreobjectrosdok_disshab_0000002374rosdok_disshab_0000002374rosdokdisshabrosdok_derivate_00000940592023-08-08T10:11:55.559Z2020-11-09T10:02:45.767ZadministratoreditorDpublished1rosdok_derivate_0000094059truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000028001738232549Oau2020-11-092023-08-05T19:15:39ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)This study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our data revealed the adding functionalities for the repression activities of ZNF746; DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and the SUMOylation might stabilize the repression complex and directly recruit chromatin modifiers.MohannadAl Chiblak1982 -VerfasserInaut1221081209MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XHans-JürgenThiesen1956 -AkademischeR BetreuerIndgs136714013ChristianSina1976 -AkademischeR BetreuerIndgs12892459438329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002800urn:nbn:de:gbv:28-rosdok_id00002800-310.18453/rosdok_id00002800570 Biowissenschaften, BiologieUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2020Universität RostockRostockmonographic202020202020Universitätsbibliothek RostockRostock2020Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002800Markus Tiedge (Universitätsmedizin Rostock, Institut für Medizinische Biochemie und Molekularbiologie) ; Hans-Jürgen Thiesen (Universitätsmedizin Rostock, Institut für Immunologie) ; Christian Sina (Universitätsklinikum Schleswig-Holstein, Institut für Ernährungsmedizin)vorgelegt von Mohannadd Al ChiblakWG 1940Zink-Finger-ProteineGenexpressiondoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)Transcription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)gnd:1221081209gnd:13860231Xgnd:136714013gnd:128924594gnd:38329-6gnd:1029510660gnd:1221081209gnd:13860231Xgnd:136714013gnd:128924594gnd:38329-6gnd:1029510660rosdok_disshab_0000002374-d548619e52gnd:1221081209Mohannad Al ChiblakMohannad Al Chiblakrosdok_disshab_0000002374-d548619e66gnd:13860231XMarkus TiedgeMarkus Tiedgerosdok_disshab_0000002374-d548619e80gnd:136714013Hans-Jürgen ThiesenHans-Jürgen Thiesenrosdok_disshab_0000002374-d548619e94gnd:128924594Christian SinaChristian Sinarosdok_disshab_0000002374-d548619e109gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002374-d548619e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockMohannad Al ChiblakMarkus TiedgeHans-Jürgen ThiesenChristian SinaUniversität RostockUniversitätsmedizin RostockMohannad Al ChiblakMarkus TiedgeHans-Jürgen ThiesenChristian SinaUniversität RostockUniversitätsmedizin RostockMohannad Al ChiblakRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002800urn:nbn:de:gbv:28-rosdok_id00002800-310.18453/rosdok_id00002800WG 1940Zink-Finger-ProteineGenexpressionThis study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our data revealed the adding functionalities for the repression activities of ZNF746; DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and the SUMOylation might stabilize the repression complex and directly recruit chromatin modifiers.20202020Markus Tiedge (Universitätsmedizin Rostock, Institut für Medizinische Biochemie und Molekularbiologie) ; Hans-Jürgen Thiesen (Universitätsmedizin Rostock, Institut für Immunologie) ; Christian Sina (Universitätsklinikum Schleswig-Holstein, Institut für Ernährungsmedizin)vorgelegt von Mohannadd Al Chiblakepub.dissertation1 Al-Chiblak_Dissertation_2020.pdf 4815298 7fe7b44443a8c3c1a72791d5f5add59f rosdok/id000028001738232549Oau2020-11-092023-08-05T19:15:39ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)This study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our data revealed the adding functionalities for the repression activities of ZNF746; DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and the SUMOylation might stabilize the repression complex and directly recruit chromatin modifiers.MohannadAl Chiblak1982 -VerfasserInaut1221081209MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XHans-JürgenThiesen1956 -AkademischeR BetreuerIndgs136714013ChristianSina1976 -AkademischeR BetreuerIndgs12892459438329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002800urn:nbn:de:gbv:28-rosdok_id00002800-310.18453/rosdok_id00002800570 Biowissenschaften, BiologieUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2020Universität RostockRostockmonographic202020202020Universitätsbibliothek RostockRostock2020Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002800Markus Tiedge (Universitätsmedizin Rostock, Institut für Medizinische Biochemie und Molekularbiologie) ; Hans-Jürgen Thiesen (Universitätsmedizin Rostock, Institut für Immunologie) ; Christian Sina (Universitätsklinikum Schleswig-Holstein, Institut für Ernährungsmedizin)vorgelegt von Mohannadd Al ChiblakWG 1940Zink-Finger-ProteineGenexpression 2020-11-09T10:02:45.767Z 2023-08-08T10:11:55.559Z 2023-08-18T10:11:55.563Z {"identifier":"rosdok/id00002800","type":"local_id","additional":"","service":"MCRLocalID","created":"2020-11-09T10:02:46.092Z"} editorD {"identifier":"http://purl.uni-rostock.de/rosdok/id00002800","type":"purl","additional":"","service":"RosDokPURL","created":"2020-11-09T10:12:26.992Z","registered":"2020-11-09T10:12:26.992Z"} {"identifier":"10.18453/rosdok_id00002800","type":"doi","additional":"","service":"RosDokDOI","created":"2020-11-09T10:12:29.852Z","registered":"2020-11-09T10:12:29.852Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00002800-3","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2020-11-09T10:02:46.357Z","registered":"2020-11-10T03:12:56.700Z"} administratorfulltextfile/rosdok_disshab_0000002374/rosdok_derivate_0000094059/Al-Chiblak_Dissertation_2020.pdfTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)Transcription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)gnd:1221081209gnd:13860231Xgnd:136714013gnd:128924594gnd:38329-6gnd:1029510660gnd:1221081209gnd:13860231Xgnd:136714013gnd:128924594gnd:38329-6gnd:1029510660rosdok_disshab_0000002374-d548619e52gnd:1221081209Mohannad Al ChiblakMohannad Al Chiblakrosdok_disshab_0000002374-d548619e66gnd:13860231XMarkus TiedgeMarkus Tiedgerosdok_disshab_0000002374-d548619e80gnd:136714013Hans-Jürgen ThiesenHans-Jürgen Thiesenrosdok_disshab_0000002374-d548619e94gnd:128924594Christian SinaChristian Sinarosdok_disshab_0000002374-d548619e109gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002374-d548619e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockMohannad Al ChiblakMarkus TiedgeHans-Jürgen ThiesenChristian SinaUniversität RostockUniversitätsmedizin RostockMohannad Al ChiblakMarkus TiedgeHans-Jürgen ThiesenChristian SinaUniversität RostockUniversitätsmedizin RostockMohannad Al ChiblakRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002800urn:nbn:de:gbv:28-rosdok_id00002800-310.18453/rosdok_id00002800WG 1940Zink-Finger-ProteineGenexpressionThis study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain was confirmed in our study. Our data revealed the adding functionalities for the repression activities of ZNF746; DUF3669 as an oligomerizing domain might recruit other DUF3669-KRAB-ZNF proteins and the SUMOylation might stabilize the repression complex and directly recruit chromatin modifiers.20202020Markus Tiedge (Universitätsmedizin Rostock, Institut für Medizinische Biochemie und Molekularbiologie) ; Hans-Jürgen Thiesen (Universitätsmedizin Rostock, Institut für Immunologie) ; Christian Sina (Universitätsklinikum Schleswig-Holstein, Institut für Ernährungsmedizin)vorgelegt von Mohannadd Al Chiblak[xslt]Saxonrosdok/id00002800https://purl.uni-rostock.de/rosdok/id00002800173823254910.18453/rosdok_id00002800urn:nbn:de:gbv:28-rosdok_id00002800-3Mohannad Al ChiblakAl Chiblak MohannadTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)Dissertationdoctoral thesisUniversität Rostock, 2020This study evaluates the repression activities of two DUF3669-containing KRAB-ZNF proteins; ZNF746 and ZNF777 in addition to the oligomerizing ability of their domain of unknown function (DUF3669). A new domain model for DUF3669 has been established in this study. DUF3669 as an oligomerizing domain…Mohannad Al ChiblakTranscription factor properties of ZNF746 and ZNF777 with focus on their domains of unknown function 3669 (DUF3669)Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002800MohannadAl Chiblak1982 -VerfasserInaut1221081209MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XHans-JürgenThiesen1956 -AkademischeR BetreuerIndgs136714013ChristianSina1976 -AkademischeR BetreuerIndgs12892459438329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002800[urn]urn:nbn:de:gbv:28-rosdok_id00002800-3[doi]10.18453/rosdok_id00002800open_access20202020epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.umrstate:published