mycoreobjectrosdok_disshab_0000002375rosdok_disshab_0000002375rosdokdisshabrosdok_derivate_00000942552023-08-08T10:11:56.244Z2020-11-10T09:15:51.801ZadministratoreditorDpublished1rosdok_derivate_0000094255truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000028011738299295Oau2020-11-102023-08-05T19:15:40ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancyFetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.Charles AyensuOkai1974 -VerfasserInaut1221141015MichaelGlocker1960 -AkademischeR BetreuerIndgs10140521650000-0001-9190-482XUlrichPecks1975 -AkademischeR BetreuerIndgs1321418090000-0002-0784-1262Hugo IstvanMurua Escobar1973 -AkademischeR BetreuerIndgs12980455X38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002801urn:nbn:de:gbv:28-rosdok_id00002801-910.18453/rosdok_id00002801540 Chemie570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2020Universität RostockRostockmonographic202020202020Universitätsbibliothek RostockRostock2020Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002801Michael O. 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UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancyProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancygnd:1221141015gnd:1014052165orcid:0000-0001-9190-482Xgnd:132141809orcid:0000-0002-0784-1262gnd:12980455Xgnd:38329-6gnd:1029510660gnd:1221141015gnd:1014052165orcid:0000-0001-9190-482Xgnd:132141809orcid:0000-0002-0784-1262gnd:12980455Xgnd:38329-6gnd:1029510660rosdok_disshab_0000002375-d594804e53gnd:1221141015Charles Ayensu OkaiCharles Ayensu Okairosdok_disshab_0000002375-d594804e67gnd:1014052165orcid:0000-0001-9190-482XMichael GlockerMichael Glockerrosdok_disshab_0000002375-d594804e83gnd:132141809orcid:0000-0002-0784-1262Ulrich PecksUlrich Pecksrosdok_disshab_0000002375-d594804e99gnd:12980455XHugo Istvan Murua EscobarHugo Istvan Murua Escobarrosdok_disshab_0000002375-d594804e114gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002375-d594804e125gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockCharles Ayensu OkaiMichael GlockerUlrich PecksHugo Istvan Murua EscobarUniversität RostockUniversitätsmedizin RostockCharles Ayensu OkaiMichael GlockerUlrich PecksHugo Istvan Murua EscobarUniversität RostockUniversitätsmedizin RostockCharles Ayensu OkaiRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002801urn:nbn:de:gbv:28-rosdok_id00002801-910.18453/rosdok_id00002801YM 5817SchwangerschaftProteomanalyseBlutserumFetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.20202020Michael O. Glocker (Universität Rostock, Proteom Zentrum Rostock) ; Ulrich Pecks (Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe) ; Hugo Murua Escobar (Universität Rostock, Zentrum für Innere Medizin, Medizinische Klinik III - Hämatologie, Onkologie, Palliativmedizin)vorgelegt von Charles Ayensu Okaiepub.dissertation1 Okai_Dissertation_2020.pdf 4296695 ddf7a05fdcdc32a79d96071bbe208ea8 rosdok/id000028011738299295Oau2020-11-102023-08-05T19:15:40ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancyFetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. 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Glocker (Universität Rostock, Proteom Zentrum Rostock) ; Ulrich Pecks (Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe) ; Hugo Murua Escobar (Universität Rostock, Zentrum für Innere Medizin, Medizinische Klinik III - Hämatologie, Onkologie, Palliativmedizin)vorgelegt von Charles Ayensu OkaiYM 5817SchwangerschaftProteomanalyseBlutserum 2020-11-10T09:15:51.801Z 2023-08-08T10:11:56.244Z 2023-08-18T10:11:56.249Z {"identifier":"rosdok/id00002801","type":"local_id","additional":"","service":"MCRLocalID","created":"2020-11-10T09:15:51.857Z"} editorD {"identifier":"http://purl.uni-rostock.de/rosdok/id00002801","type":"purl","additional":"","service":"RosDokPURL","created":"2020-11-10T09:22:57.977Z","registered":"2020-11-10T09:22:57.977Z"} {"identifier":"10.18453/rosdok_id00002801","type":"doi","additional":"","service":"RosDokDOI","created":"2020-11-10T09:23:00.319Z","registered":"2020-11-10T09:23:00.319Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00002801-9","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2020-11-10T09:15:51.887Z","registered":"2020-11-11T03:13:03.547Z"} administratorfulltextfile/rosdok_disshab_0000002375/rosdok_derivate_0000094255/Okai_Dissertation_2020.pdfProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancyProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancygnd:1221141015gnd:1014052165orcid:0000-0001-9190-482Xgnd:132141809orcid:0000-0002-0784-1262gnd:12980455Xgnd:38329-6gnd:1029510660gnd:1221141015gnd:1014052165orcid:0000-0001-9190-482Xgnd:132141809orcid:0000-0002-0784-1262gnd:12980455Xgnd:38329-6gnd:1029510660rosdok_disshab_0000002375-d594804e53gnd:1221141015Charles Ayensu OkaiCharles Ayensu Okairosdok_disshab_0000002375-d594804e67gnd:1014052165orcid:0000-0001-9190-482XMichael GlockerMichael Glockerrosdok_disshab_0000002375-d594804e83gnd:132141809orcid:0000-0002-0784-1262Ulrich PecksUlrich Pecksrosdok_disshab_0000002375-d594804e99gnd:12980455XHugo Istvan Murua EscobarHugo Istvan Murua Escobarrosdok_disshab_0000002375-d594804e114gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002375-d594804e125gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockCharles Ayensu OkaiMichael GlockerUlrich PecksHugo Istvan Murua EscobarUniversität RostockUniversitätsmedizin RostockCharles Ayensu OkaiMichael GlockerUlrich PecksHugo Istvan Murua EscobarUniversität RostockUniversitätsmedizin RostockCharles Ayensu OkaiRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002801urn:nbn:de:gbv:28-rosdok_id00002801-910.18453/rosdok_id00002801YM 5817SchwangerschaftProteomanalyseBlutserumFetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass spectrometry. Separation confidence reached a sensitivity of 0.90, specificity of 0.79 with an area under curve of 0.88 in receiver operator characteristics. Proteome profiling by affinity-mass spectrometry during pregnancy provides a reliable method for risk assessment of impaired development in fetuses.20202020Michael O. Glocker (Universität Rostock, Proteom Zentrum Rostock) ; Ulrich Pecks (Universitätsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynäkologie und Geburtshilfe) ; Hugo Murua Escobar (Universität Rostock, Zentrum für Innere Medizin, Medizinische Klinik III - Hämatologie, Onkologie, Palliativmedizin)vorgelegt von Charles Ayensu Okai[xslt]Saxonrosdok/id00002801https://purl.uni-rostock.de/rosdok/id00002801173829929510.18453/rosdok_id00002801urn:nbn:de:gbv:28-rosdok_id00002801-9Charles Ayensu OkaiOkai Charles AyensuProteome profiling of maternal serum : a novel approach for intrauterine growth restriction screening during pregnancyDissertationdoctoral thesisUniversität Rostock, 2020Fetal growth restriction affects pregnancies leading to perinatal mortality and morbidity. Current diagnostic method is by ultrasound inspection but cannot differentiate SGA fetuses from IUGR fetuses. Maternal serum from IUGR, SGA and control pregnant women were analysed using affinity-mass…Charles Ayensu OkaiProteome profiling of maternal seruma novel approach for intrauterine growth restriction screening during pregnancyUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002801Charles AyensuOkai1974 -VerfasserInaut1221141015MichaelGlocker1960 -AkademischeR BetreuerIndgs10140521650000-0001-9190-482XUlrichPecks1975 -AkademischeR BetreuerIndgs1321418090000-0002-0784-1262Hugo IstvanMurua Escobar1973 -AkademischeR BetreuerIndgs12980455X38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002801[urn]urn:nbn:de:gbv:28-rosdok_id00002801-9[doi]10.18453/rosdok_id00002801open_access20202020epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:540SDNB:570SDNB:610institution:unirostock.umrstate:published