10.18453/rosdok_id00002896 Thiele, Frauke Frauke Thiele http://d-nb.info/gnd/1225490286 Universität Rostock 2019 570 Life science 610 Medical sciences Medicine 2019 en http://purl.uni-rostock.de/rosdok/id00002896 urn:nbn:de:gbv:28-rosdok_id00002896-1 Aberrant behaviour of resident cells causes several illnesses. Among them, cardiovascular diseases are the leading cause of death in the western world. The human heart possesses only negligible myocardial regeneration capacity after a myocardial infarction, thus, it cannot compensate the massive cell loss self-reliantly. The thesis addresses the optimization of different cell biological approaches for enrichment of cardiac subtypes. Moreover, the thesis demonstrates different genetic manipulation strategies (DNA-, mRNA- and microRNA-based) for an efficient modulation of cell fate.