mycoreobjectrosdok_disshab_0000002482rosdok_disshab_0000002482rosdokdisshabrosdok_derivate_00000996922023-08-08T10:12:43.816Z2021-03-24T08:42:35.080ZadministratoreditorDpublished1rosdok_derivate_0000099692truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000029851752313488Oau2021-03-242023-08-05T19:16:58ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesOvarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.ArpnaSharma1987 -VerfasserInaut1230002022BeateBraun1974 -AkademischeR BetreuerIndgs123616204ChristianePfarrerAkademischeR BetreuerIndgs1131995890000-0001-5282-8406JensVanselow1960 -AkademischeR BetreuerIndgs12362803238329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00002985urn:nbn:de:gbv:28-rosdok_id00002985-610.18453/rosdok_id00002985570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2020Universität RostockRostockmonographic202120202021Universitätsbibliothek RostockRostock2021Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002985Enthält ZeitschriftenartikelBeate Brown (Reproductive Biology, Leibniz Institute for Zoo and Wildlife Research (IZW) Berlin) ; Christiane Pastor (Veterinary University Hannover, Anatomical Institute) ; Jens Vanselow (Leibniz Institute for Livestock Biology (FBN) Dummerstorf)vorgelegt von ARPNA SharmaZD 32100RindStressorOvulationdoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesgnd:1230002022gnd:123616204gnd:113199589orcid:0000-0001-5282-8406gnd:123628032gnd:38329-6gnd:2147083-2gnd:1230002022gnd:123616204gnd:113199589orcid:0000-0001-5282-8406gnd:123628032gnd:38329-6gnd:2147083-2rosdok_disshab_0000002482-d604163e52gnd:1230002022Arpna SharmaArpna Sharmarosdok_disshab_0000002482-d604163e66gnd:123616204Beate BraunBeate Braunrosdok_disshab_0000002482-d604163e80gnd:113199589orcid:0000-0001-5282-8406Christiane PfarrerChristiane Pfarrerrosdok_disshab_0000002482-d604163e94gnd:123628032Jens VanselowJens Vanselowrosdok_disshab_0000002482-d604163e109gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002482-d604163e120gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätArpna SharmaBeate BraunChristiane PfarrerJens VanselowUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätArpna SharmaBeate BraunChristiane PfarrerJens VanselowUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätArpna SharmaRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00002985urn:nbn:de:gbv:28-rosdok_id00002985-610.18453/rosdok_id00002985ZD 32100RindStressorOvulationOvarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.20202020Enthält ZeitschriftenartikelBeate Brown (Reproductive Biology, Leibniz Institute for Zoo and Wildlife Research (IZW) Berlin) ; Christiane Pastor (Veterinary University Hannover, Anatomical Institute) ; Jens Vanselow (Leibniz Institute for Livestock Biology (FBN) Dummerstorf)vorgelegt von ARPNA Sharmaepub.dissertation1 Sharma_Dissertation_2021.pdf 12236873 e659b4f0753518736bc19a3b9963d744 rosdok/id000029851752313488Oau2021-03-242023-08-05T19:16:58ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesOvarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). 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High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of genes that initiate luteinization. These effects were partly mediated by hypoxia inducible factor1 (HIF1). Thus, ovarian follicles are susceptible to elevated NEFA levels, but cope up with severe hypoxia prevailing during late folliculogenesis through specific transcription factors such as HIF1.20202020Enthält ZeitschriftenartikelBeate Brown (Reproductive Biology, Leibniz Institute for Zoo and Wildlife Research (IZW) Berlin) ; Christiane Pastor (Veterinary University Hannover, Anatomical Institute) ; Jens Vanselow (Leibniz Institute for Livestock Biology (FBN) Dummerstorf)vorgelegt von ARPNA Sharma[xslt]Saxonrosdok/id00002985https://purl.uni-rostock.de/rosdok/id00002985175231348810.18453/rosdok_id00002985urn:nbn:de:gbv:28-rosdok_id00002985-6Arpna SharmaSharma ArpnaStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesDissertationdoctoral thesisUniversität Rostock, 2020Ovarian follicles are exposed to stressors such as higher levels of non-esterified free fatty acids (NEFAs) or hypoxia. High follicular levels of NEFA severely affect granulosa cells (GCs) by targeting key genes of estradiol biosynthesis. Cultured GCs exposed to hypoxia showed specific regulation of…Arpna SharmaStressors modulating granulosa cell functionality, ovulation and oocyte competence in bovinesUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00002985ArpnaSharma1987 -VerfasserInaut1230002022BeateBraun1974 -AkademischeR BetreuerIndgs123616204ChristianePfarrerAkademischeR BetreuerIndgs1131995890000-0001-5282-8406JensVanselow1960 -AkademischeR BetreuerIndgs12362803238329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00002985[urn]urn:nbn:de:gbv:28-rosdok_id00002985-6[doi]10.18453/rosdok_id00002985open_access20202020epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:570institution:unirostock.mnfstate:published