10.18453/rosdok_id00003037 Shang, Yuru Yuru Shang http://d-nb.info/gnd/1234676052 Universität Rostock 2021 570 Life science 610 Medical sciences Medicine 2021 en http://purl.uni-rostock.de/rosdok/id00003037 urn:nbn:de:gbv:28-rosdok_id00003037-4 The aim of this study was to investigate the effect of therapeutically used immunoglobulin G (IgG) on colon cancer in the presence of oxaliplatin. We observed that IgG failed to significantly influence tumor cell viability and tumor growth; however, it significantly inhibited the cytotoxic activity of oxaliplatin in vitro. In addition, we observed that oxaliplatin-induced the activation of ERK; however, IgG inhibits ERK activity. This implies that the application of therapeutical IgG to treating patients, which are receiving oxaliplatin, might have harmful side effects.