Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells

10.18453/rosdok_id00003164 Lu, Lili Lili Lu http://d-nb.info/gnd/1241495157 https://orcid.org/0000-0001-6638-624X Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in colorectal cancer cells Universität Rostock 2021 500 Natural sciences 610 Medical sciences Medicine 2021 en http://purl.uni-rostock.de/rosdok/id00003164 urn:nbn:de:gbv:28-rosdok_id00003164-0 The present study aimed at 1) testing the sensitivity of CRC cell lines with defined molecular alterations to curcumin; 2) mechanistically analyzing sensitive CRC cell lines in order to identify the mode-of-action; 3) identifying biomarkers associated with curcumin sensitivity; 4) establishing a predictive model using biomarkers to predict the sensitivity of additional CRC cell line to curcumin.