10.18453/rosdok_id00003623 Butenko, Konstantin Konstantin Butenko http://d-nb.info/gnd/1255792531 https://orcid.org/0000-0002-4509-4624 Universität Rostock 2021 620 Engineering & allied operations 2021 en http://purl.uni-rostock.de/rosdok/id00003623 urn:nbn:de:gbv:28-rosdok_id00003623-9 Deep brain stimulation is an established treatment for Parkinson’s disease (PD). However, to advance its effectiveness, researchers need to gain a better understanding of the action mechanism by means of in vivo and in silico studies. This thesis presents neural activation patterns theoretically beneficial for motor improvement in PD and analyzes their theoretical reproducibility in a rat brain. Besides, it elucidates biophysical and computational problems to be addressed in order to optimize animal studies and avoid misconceptions when transferring experimental findings to clinical trials.