mycoreobjectrosdok_disshab_0000002746rosdok_disshab_0000002746rosdokdisshabrosdok_derivate_00001961112023-08-08T10:14:11.231Z2022-06-23T10:48:58.773ZadministratoreditorMSpublished1rosdok_derivate_0000196111truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000037131807555275Oau2022-06-232023-08-05T19:20:05ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftDefective myelination and its relative mechanism in Niemann-Pick type C diseaseNiemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.FanYang1986 -VerfasserInaut1260687694JiankaiLuoAkademischeR BetreuerIndgsUniversitätsmedizin RostockRüdigerKöhling1966 -AkademischeR BetreuerIndgs1375857560000-0003-3330-4898Universitätsmedizin RostockThomasPufe1972 -AkademischeR BetreuerIndgs123045371Universitätsklinikum Aachen38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00003713urn:nbn:de:gbv:28-rosdok_id00003713-910.18453/rosdok_id00003713500 Naturwissenschaften570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinCC BY 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2019Universität RostockRostockmonographic202220192022Universitätsbibliothek RostockRostock2022Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00003713Jiankai Luo (Universitätsmedizin Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Thomas Pufe (Universitätsklinikum Aachen)[{"affil":"Universitätsmedizin Rostock","name":"Luo, Jiankai"},{"affil":"Universitätsmedizin Rostock","name":"Köhling, Rüdiger"},{"affil":"Universitätsklinikum Aachen","name":"Pufe, Thomas"}]vorgelegt von Fan YangYC 7417Niemann-Pick-KrankheitMyelogeneseUniversitätsmedizin RostockLuo, JiankaiUniversitätsmedizin RostockKöhling, RüdigerUniversitätsklinikum AachenPufe, Thomasdoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.cclicenselicenseinfo:work.cclicenseCC-LizenzCC-licenselicenseinfo:work.cclicense.cc-bylicenseinfo:work.cclicense.cc-byCC BYCC BYlicenseinfo:work.cclicense.cc-by.v40licenseinfo:work.cclicense.cc-by.v40CC BY 4.0CC BY 4.0/creativecommons/l/by/4.0/88x31.png[DE-28]Namensnennung 4.0 International$cCC BY 4.0$gCreative Commons$uhttps://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/https://creativecommons.org/licenses/by/4.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengDefective myelination and its relative mechanism in Niemann-Pick type C diseaseDefective myelination and its relative mechanism in Niemann-Pick type C diseasegnd:1260687694gnd:137585756orcid:0000-0003-3330-4898gnd:123045371gnd:38329-6gnd:1029510660gnd:1260687694gnd:137585756orcid:0000-0003-3330-4898gnd:123045371gnd:38329-6gnd:1029510660rosdok_disshab_0000002746-d1002198e52gnd:1260687694Fan YangFan Yangrosdok_disshab_0000002746-d1002198e66Jiankai LuoJiankai Luorosdok_disshab_0000002746-d1002198e77gnd:137585756orcid:0000-0003-3330-4898Rüdiger KöhlingRüdiger Köhlingrosdok_disshab_0000002746-d1002198e94gnd:123045371Thomas PufeThomas Puferosdok_disshab_0000002746-d1002198e110gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002746-d1002198e121gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockFan YangJiankai LuoRüdiger KöhlingThomas PufeUniversität RostockUniversitätsmedizin RostockFan YangJiankai LuoRüdiger KöhlingThomas PufeUniversität RostockUniversitätsmedizin RostockFan YangRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00003713urn:nbn:de:gbv:28-rosdok_id00003713-910.18453/rosdok_id00003713YC 7417Niemann-Pick-KrankheitMyelogeneseNiemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.20192019Jiankai Luo (Universitätsmedizin Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Thomas Pufe (Universitätsklinikum Aachen)[{"affil":"Universitätsmedizin Rostock","name":"Luo, Jiankai"},{"affil":"Universitätsmedizin Rostock","name":"Köhling, Rüdiger"},{"affil":"Universitätsklinikum Aachen","name":"Pufe, Thomas"}]vorgelegt von Fan Yangepub.dissertation1 Yang_Dissertation_2022.pdf 4229059 1ba9850f4a79c6366d6eac3127da2918 rosdok/id000037131807555275Oau2022-06-232023-08-05T19:20:05ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.7 [SCM: "0c0e7a3c226a4a0cbcbec39b493c3c5257339ab8" "v2.7" "2023-08-04T00:00:00+0200"] with mode 'DEFAULT'.DissertationHochschulschriftDefective myelination and its relative mechanism in Niemann-Pick type C diseaseNiemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.FanYang1986 -VerfasserInaut1260687694JiankaiLuoAkademischeR BetreuerIndgsUniversitätsmedizin RostockRüdigerKöhling1966 -AkademischeR BetreuerIndgs1375857560000-0003-3330-4898Universitätsmedizin RostockThomasPufe1972 -AkademischeR BetreuerIndgs123045371Universitätsklinikum Aachen38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00003713urn:nbn:de:gbv:28-rosdok_id00003713-910.18453/rosdok_id00003713500 Naturwissenschaften570 Biowissenschaften, Biologie610 Medizin, GesundheitUniversitätsmedizinCC BY 4.0Nutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2019Universität RostockRostockmonographic202220192022Universitätsbibliothek RostockRostock2022Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00003713Jiankai Luo (Universitätsmedizin Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Thomas Pufe (Universitätsklinikum Aachen)[{"affil":"Universitätsmedizin Rostock","name":"Luo, Jiankai"},{"affil":"Universitätsmedizin Rostock","name":"Köhling, Rüdiger"},{"affil":"Universitätsklinikum Aachen","name":"Pufe, Thomas"}]vorgelegt von Fan YangYC 7417Niemann-Pick-KrankheitMyelogenese Universitätsmedizin Rostock Luo, Jiankai Universitätsmedizin Rostock Köhling, Rüdiger Universitätsklinikum Aachen Pufe, Thomas 2022-06-23T10:48:58.773Z 2023-08-08T10:14:11.231Z 2023-08-18T10:14:11.236Z {"identifier":"rosdok/id00003713","type":"local_id","additional":"","service":"MCRLocalID","created":"2022-06-23T10:48:58.788Z","registered":"2022-06-23T10:48:58.788Z"} editorMS {"identifier":"urn:nbn:de:gbv:28-rosdok_id00003713-9","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2022-06-23T10:48:58.794Z","registered":"2022-06-23T18:40:58.823Z"} administratorfulltextfile/rosdok_disshab_0000002746/rosdok_derivate_0000196111/Yang_Dissertation_2022.pdfDefective myelination and its relative mechanism in Niemann-Pick type C diseaseDefective myelination and its relative mechanism in Niemann-Pick type C diseasegnd:1260687694gnd:137585756orcid:0000-0003-3330-4898gnd:123045371gnd:38329-6gnd:1029510660gnd:1260687694gnd:137585756orcid:0000-0003-3330-4898gnd:123045371gnd:38329-6gnd:1029510660rosdok_disshab_0000002746-d1002198e52gnd:1260687694Fan YangFan Yangrosdok_disshab_0000002746-d1002198e66Jiankai LuoJiankai Luorosdok_disshab_0000002746-d1002198e77gnd:137585756orcid:0000-0003-3330-4898Rüdiger KöhlingRüdiger Köhlingrosdok_disshab_0000002746-d1002198e94gnd:123045371Thomas PufeThomas Puferosdok_disshab_0000002746-d1002198e110gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000002746-d1002198e121gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockFan YangJiankai LuoRüdiger KöhlingThomas PufeUniversität RostockUniversitätsmedizin RostockFan YangJiankai LuoRüdiger KöhlingThomas PufeUniversität RostockUniversitätsmedizin RostockFan YangRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00003713urn:nbn:de:gbv:28-rosdok_id00003713-910.18453/rosdok_id00003713YC 7417Niemann-Pick-KrankheitMyelogeneseNiemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2 was inhibited in NPC1-/- oligodendrocytes. Treatment of lovastatin reduced accumulation of cholesterol in the late endosomal and lysosomal, increased the expression of Olig1 and Olig2, recovered the nucleocytoplasmic transport of p57Kip2, and restored the maturation of NPC1-/- oligodendrocytes.20192019Jiankai Luo (Universitätsmedizin Rostock) ; Rüdiger Köhling (Universitätsmedizin Rostock) ; Thomas Pufe (Universitätsklinikum Aachen)[{"affil":"Universitätsmedizin Rostock","name":"Luo, Jiankai"},{"affil":"Universitätsmedizin Rostock","name":"Köhling, Rüdiger"},{"affil":"Universitätsklinikum Aachen","name":"Pufe, Thomas"}]vorgelegt von Fan Yang[xslt]Saxonrosdok/id00003713https://purl.uni-rostock.de/rosdok/id00003713180755527510.18453/rosdok_id00003713urn:nbn:de:gbv:28-rosdok_id00003713-9Fan YangYang FanDefective myelination and its relative mechanism in Niemann-Pick type C diseaseDissertationdoctoral thesisUniversität Rostock, 2019Niemann-Pick type C (NPC) disease is caused by mutations in npc1 or npc2 gene. In this study, we found the maturation of NPC1-/- oligodendrocytes was significantly inhibited, the myelin-related transcription factors Olig1 and Olig2 were downregulated and the nucleocytoplasmic transport of p57Kip2…Fan YangDefective myelination and its relative mechanism in Niemann-Pick type C diseaseUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00003713FanYang1986 -VerfasserInaut1260687694JiankaiLuoAkademischeR BetreuerIndgsUniversitätsmedizin RostockRüdigerKöhling1966 -AkademischeR BetreuerIndgs1375857560000-0003-3330-4898Universitätsmedizin RostockThomasPufe1972 -AkademischeR BetreuerIndgs123045371Universitätsklinikum Aachen38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00003713[urn]urn:nbn:de:gbv:28-rosdok_id00003713-9[doi]10.18453/rosdok_id00003713open_access20192019epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:500SDNB:570SDNB:610institution:unirostock.umrstate:published