10.18453/rosdok_id00004407 Salewski, Inken Inken Salewski http://d-nb.info/gnd/1222442876 https://orcid.org/0000-0002-5738-4696 Universität Rostock 2023 500 Natural sciences 570 Life science 610 Medical sciences Medicine 2023 en http://purl.uni-rostock.de/rosdok/id00004407 urn:nbn:de:gbv:28-rosdok_id00004407-6 In this thesis, different immunotherapy strategies we employed to combat mismatch-repair-deficient (dMMR) cancer. We used two preclinical mouse models, either having constitutional (Mlh1) or conditional (Msh2) knock out. To prevent resistance development and improve outcome, we focused on combination strategies including whole tumor vaccines, immune checkpoint-inhibitors (α-PD-L1), classical chemotherapy or the Cyclin-dependent kinase inhibitor abemaciclib. By applying different combination strategies, a significant survival benefit was reached in all investigated treatments.