mycoreobjectrosdok_disshab_0000003032rosdok_disshab_0000003032rosdokdisshabrosdok_derivate_00002094972023-08-25T10:00:02.500Z2023-08-24T08:31:24.926ZMCRJANITOReditorMSpublished1rosdok_derivate_0000209497truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000044091857865693Oau2023-08-242023-08-24T08:33:55ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.6 [SCM: "64e51f5d78111d251437b6cc6ce7ce9e6587ae8d" "v2.6" "2023-08-03T11:35:27+0200"] with mode 'DEFAULT'.DissertationHochschulschriftCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsThis dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.Svenja HannahOffer1992 -VerfasserInaut1300025026RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025Institut für Chemie, Universität RostockBarbaraRothen-RutishauserAkademischeR BetreuerIndgsAdolphe Merkle Institut, Universität Fribourg, Schweiz38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00004409urn:nbn:de:gbv:28-rosdok_id00004409-810.18453/rosdok_id00004409500 Naturwissenschaften540 Chemie570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2023Universität RostockRostockmonographic202320232023Universitätsbibliothek RostockRostock2023Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00004409Enthält ZeitschriftenartikelRalf Zimmermann (Institut für Chemie, Universität Rostock) ; Barbara Rothen-Rutishauser (Adolphe Merkle Institut, Universität Fribourg, Schweiz)[{"name":"Zimmermann, Ralf","affil":"Institut für Chemie, Universität Rostock"},{"name":"Rothen-Rutishauser, Barbara","affil":"Adolphe Merkle Institut, Universität Fribourg, Schweiz"}]vorgelegt von Svenja Hannah OfferZimmermann, RalfInstitut für Chemie, Universität RostockRothen-Rutishauser, BarbaraAdolphe Merkle Institut, Universität Fribourg, Schweizdoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesSDNB:540SDNB:540540 Chemie540 Chemistry & allied sciencesSDNB:570SDNB:570570 Biowissenschaften, Biologie570 Life scienceinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.mnfinstitution:unirostock.mnfMathematisch-Naturwissenschaftliche FakultätFaculty of Mathematics and Natural SciencesUniversität Rostock. Mathematisch-Naturwissenschaftliche FakultätMathematisch-Natur-<br />wissenschaftliche FakultätUni.Rostock.Fakultaet.MNFhttp://d-nb.info/gnd/2147083-2licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsgnd:1300025026gnd:143922025gnd:38329-6gnd:2147083-2gnd:1300025026gnd:143922025gnd:38329-6gnd:2147083-2rosdok_disshab_0000003032-d302881e52gnd:1300025026Svenja Hannah OfferSvenja Hannah Offerrosdok_disshab_0000003032-d302881e66gnd:143922025Ralf ZimmermannRalf Zimmermannrosdok_disshab_0000003032-d302881e81Barbara Rothen-RutishauserBarbara Rothen-Rutishauserrosdok_disshab_0000003032-d302881e92gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003032-d302881e104gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRalf ZimmermannBarbara Rothen-RutishauserUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRalf ZimmermannBarbara Rothen-RutishauserUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00004409urn:nbn:de:gbv:28-rosdok_id00004409-810.18453/rosdok_id00004409This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.20232023Enthält ZeitschriftenartikelRalf Zimmermann (Institut für Chemie, Universität Rostock) ; Barbara Rothen-Rutishauser (Adolphe Merkle Institut, Universität Fribourg, Schweiz)[{"name":"Zimmermann, Ralf","affil":"Institut für Chemie, Universität Rostock"},{"name":"Rothen-Rutishauser, Barbara","affil":"Adolphe Merkle Institut, Universität Fribourg, Schweiz"}]vorgelegt von Svenja Hannah Offerepub.dissertation1 Offer_Dissertation_2023.pdf 26827005 94cd0b5907687ff6673ae2b6729b00d2 rosdok/id000044091857865693Oau2023-08-242023-08-24T08:33:55ZrdaConverted from PICA to MODS using Pica2Mods XSLT Transformer 2.6 [SCM: "64e51f5d78111d251437b6cc6ce7ce9e6587ae8d" "v2.6" "2023-08-03T11:35:27+0200"] with mode 'DEFAULT'.DissertationHochschulschriftCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsThis dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.Svenja HannahOffer1992 -VerfasserInaut1300025026RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025Institut für Chemie, Universität RostockBarbaraRothen-RutishauserAkademischeR BetreuerIndgsAdolphe Merkle Institut, Universität Fribourg, Schweiz38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgghttp://purl.uni-rostock.de/rosdok/id00004409urn:nbn:de:gbv:28-rosdok_id00004409-810.18453/rosdok_id00004409500 Naturwissenschaften540 Chemie570 Biowissenschaften, BiologieMathematisch-Naturwissenschaftliche Fakultätalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2023Universität RostockRostockmonographic202320232023Universitätsbibliothek RostockRostock2023Universitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00004409Enthält ZeitschriftenartikelRalf Zimmermann (Institut für Chemie, Universität Rostock) ; Barbara Rothen-Rutishauser (Adolphe Merkle Institut, Universität Fribourg, Schweiz)[{"name":"Zimmermann, Ralf","affil":"Institut für Chemie, Universität Rostock"},{"name":"Rothen-Rutishauser, Barbara","affil":"Adolphe Merkle Institut, Universität Fribourg, Schweiz"}]vorgelegt von Svenja Hannah Offer Zimmermann, Ralf Institut für Chemie, Universität Rostock Rothen-Rutishauser, Barbara Adolphe Merkle Institut, Universität Fribourg, Schweiz 2023-08-24T08:31:24.926Z 2023-08-25T10:00:02.500Z 2023-09-04T10:00:02.507Z editorMS {"identifier":"rosdok/id00004409","type":"local_id","additional":"","service":"MCRLocalID","created":"2023-08-24T08:31:24.939Z"} {"identifier":"http://purl.uni-rostock.de/rosdok/id00004409","type":"purl","additional":"","service":"RosDokPURL","created":"2023-08-24T08:31:24.947Z","registrationStarted":"2023-08-24T08:37:20.871Z"} {"identifier":"10.18453/rosdok_id00004409","type":"doi","additional":"","service":"RosDokDOI","created":"2023-08-24T08:31:24.949Z","registrationStarted":"2023-08-24T08:37:20.708Z","registered":"2023-08-24T08:37:22.191Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00004409-8","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2023-08-24T08:31:24.945Z","registered":"2023-08-25T07:32:18.300Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003032/rosdok_derivate_0000209497/Offer_Dissertation_2023.pdfCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsgnd:1300025026gnd:143922025gnd:38329-6gnd:2147083-2gnd:1300025026gnd:143922025gnd:38329-6gnd:2147083-2rosdok_disshab_0000003032-d302881e52gnd:1300025026Svenja Hannah OfferSvenja Hannah Offerrosdok_disshab_0000003032-d302881e66gnd:143922025Ralf ZimmermannRalf Zimmermannrosdok_disshab_0000003032-d302881e81Barbara Rothen-RutishauserBarbara Rothen-Rutishauserrosdok_disshab_0000003032-d302881e92gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003032-d302881e104gnd:2147083-2Universität Rostock Mathematisch-Naturwissenschaftliche FakultätUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRalf ZimmermannBarbara Rothen-RutishauserUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRalf ZimmermannBarbara Rothen-RutishauserUniversität RostockUniversität Rostock Mathematisch-Naturwissenschaftliche FakultätSvenja Hannah OfferRostockUniversität Rostockepub.dissertationhttp://purl.uni-rostock.de/rosdok/id00004409urn:nbn:de:gbv:28-rosdok_id00004409-810.18453/rosdok_id00004409This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.20232023Enthält ZeitschriftenartikelRalf Zimmermann (Institut für Chemie, Universität Rostock) ; Barbara Rothen-Rutishauser (Adolphe Merkle Institut, Universität Fribourg, Schweiz)[{"name":"Zimmermann, Ralf","affil":"Institut für Chemie, Universität Rostock"},{"name":"Rothen-Rutishauser, Barbara","affil":"Adolphe Merkle Institut, Universität Fribourg, Schweiz"}]vorgelegt von Svenja Hannah Offer[xslt]Saxonrosdok/id00004409https://purl.uni-rostock.de/rosdok/id00004409185786569310.18453/rosdok_id00004409urn:nbn:de:gbv:28-rosdok_id00004409-8Svenja Hannah OfferOffer Svenja HannahCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsDissertationdoctoral thesisUniversität Rostock, 2023This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical…Svenja Hannah OfferCellular and molecular toxicity of atmospherically aged anthropogenic and biogenic aerosolsUniversitätsbibliothek Rostockhttp://purl.uni-rostock.de/rosdok/id00004409Svenja HannahOffer1992 -VerfasserInaut1300025026RalfZimmermann1963 -AkademischeR BetreuerIndgs143922025Institut für Chemie, Universität RostockBarbaraRothen-RutishauserAkademischeR BetreuerIndgsAdolphe Merkle Institut, Universität Fribourg, Schweiz38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg2147083-2Universität RostockMathematisch-Naturwissenschaftliche FakultätGrad-verleihende Institutiondgg[purl]http://purl.uni-rostock.de/rosdok/id00004409[urn]urn:nbn:de:gbv:28-rosdok_id00004409-8[doi]10.18453/rosdok_id00004409open_access20232023epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:500SDNB:540SDNB:570institution:unirostock.mnfstate:published