10.18453/rosdok_id00004409 Offer, Svenja Hannah Svenja Hannah Offer http://d-nb.info/gnd/1300025026 Universität Rostock 2023 500 Natural sciences 540 Chemistry & allied sciences 570 Life science 2023 en http://purl.uni-rostock.de/rosdok/id00004409 urn:nbn:de:gbv:28-rosdok_id00004409-8 This dissertation addresses the question about the toxicological impacts of atmospherically aged biogenic and anthropogenic emissions. In simulation experiments, an anthropogenic (naphthalene) or biogenic (β-pinene) VOC precursor was aged together with a primary aerosol and comprehensively physical and chemical characterized. Using different in vitro airway model systems [BEAS-2B, A549 and a coculture of A549/EA.hy926] in an automated air-liquid interface exposure system, the cellular effects triggered by the aerosols were tested by evaluating the genomic, metabolomic and functional changes.