mycoreobjectrosdok_disshab_0000003068rosdok_disshab_0000003068rosdokdisshabrosdok_derivate_00002119172023-11-09T11:00:03.671Z2023-11-08T11:07:07.826ZMCRJANITOReditorMSpublished1rosdok_derivate_0000211917truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000044581869704800Oau2023-11-082023-11-08T11:11:24ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.8 [SCM: "0dd72eb2002cd5e1d4341cacf34e92f44f7894b4" "v2.8" "2023-10-12T16:45:19+0200"] with mode 'DEFAULT'.DissertationHochschulschriftElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationThe PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.Loredana-MirelaLupu1992 -VerfasserInaut13091084120009-0003-5299-0907MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XInstitut für Medizinische Biochemie und MolekularbiologieMichaelGlocker1960 -AkademischeR BetreuerIndgs10140521650000-0001-9190-482XMichaelPrzybylski1948 - 2023AkademischeR BetreuerIndgs1130680797AffyMSLifeChem38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004458urn:nbn:de:gbv:28-rosdok_id00004458-610.18453/rosdok_id00004458500 NaturwissenschaftenUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2022Universität RostockRostockmonographic202320222023Universitätsbibliothek RostockRostock2023Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004458Enthält ZeitschriftenartikelMarkus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)[{"name":"Tiedge, Markus","affil":"Institut für Medizinische Biochemie und Molekularbiologie"},{"name":"Glocker, Michael O.","affil":"Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung"},{"name":"Przybylski, Michael","affil":"AffyMSLifeChem"}]vorgelegt von Loredana-Mirela LupuTiedge, MarkusInstitut für Medizinische Biochemie und MolekularbiologieGlocker, Michael O.Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für ProteomforschungPrzybylski, MichaelAffyMSLifeChemdoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:500SDNB:500500 Naturwissenschaften500 Natural sciencesinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationgnd:1309108412orcid:0009-0003-5299-0907gnd:13860231Xgnd:1014052165orcid:0000-0001-9190-482Xgnd:1130680797gnd:38329-6gnd:1029510660gnd:1309108412orcid:0009-0003-5299-0907gnd:13860231Xgnd:1014052165orcid:0000-0001-9190-482Xgnd:1130680797gnd:38329-6gnd:1029510660rosdok_disshab_0000003068-d3258924e52gnd:1309108412orcid:0009-0003-5299-0907Loredana-Mirela LupuLoredana-Mirela Lupurosdok_disshab_0000003068-d3258924e68gnd:13860231XMarkus TiedgeMarkus Tiedgerosdok_disshab_0000003068-d3258924e83gnd:1014052165orcid:0000-0001-9190-482XMichael GlockerMichael Glockerrosdok_disshab_0000003068-d3258924e99gnd:1130680797Michael PrzybylskiMichael Przybylskirosdok_disshab_0000003068-d3258924e115gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003068-d3258924e126gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockLoredana-Mirela LupuMarkus TiedgeMichael GlockerMichael PrzybylskiUniversität RostockUniversitätsmedizin RostockLoredana-Mirela LupuMarkus TiedgeMichael GlockerMichael PrzybylskiUniversität RostockUniversitätsmedizin RostockLoredana-Mirela LupuRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004458urn:nbn:de:gbv:28-rosdok_id00004458-610.18453/rosdok_id00004458The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.20222022Enthält ZeitschriftenartikelMarkus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)[{"name":"Tiedge, Markus","affil":"Institut für Medizinische Biochemie und Molekularbiologie"},{"name":"Glocker, Michael O.","affil":"Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung"},{"name":"Przybylski, Michael","affil":"AffyMSLifeChem"}]vorgelegt von Loredana-Mirela Lupuepub.dissertation1 Lupu_Dissertation_2023.pdf 8804369 99683fe53a924d373c70bd2b3152b46e rosdok/id000044581869704800Oau2023-11-082023-11-08T11:11:24ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.8 [SCM: "0dd72eb2002cd5e1d4341cacf34e92f44f7894b4" "v2.8" "2023-10-12T16:45:19+0200"] with mode 'DEFAULT'.DissertationHochschulschriftElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationThe PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.Loredana-MirelaLupu1992 -VerfasserInaut13091084120009-0003-5299-0907MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XInstitut für Medizinische Biochemie und MolekularbiologieMichaelGlocker1960 -AkademischeR BetreuerIndgs10140521650000-0001-9190-482XMichaelPrzybylski1948 - 2023AkademischeR BetreuerIndgs1130680797AffyMSLifeChem38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004458urn:nbn:de:gbv:28-rosdok_id00004458-610.18453/rosdok_id00004458500 NaturwissenschaftenUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2022Universität RostockRostockmonographic202320222023Universitätsbibliothek RostockRostock2023Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004458Enthält ZeitschriftenartikelMarkus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)[{"name":"Tiedge, Markus","affil":"Institut für Medizinische Biochemie und Molekularbiologie"},{"name":"Glocker, Michael O.","affil":"Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung"},{"name":"Przybylski, Michael","affil":"AffyMSLifeChem"}]vorgelegt von Loredana-Mirela Lupu Tiedge, Markus Institut für Medizinische Biochemie und Molekularbiologie Glocker, Michael O. Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung Przybylski, Michael AffyMSLifeChem 2023-11-08T11:07:07.826Z 2023-11-09T11:00:03.671Z 2023-11-19T11:00:03.678Z editorMS {"identifier":"rosdok/id00004458","type":"local_id","additional":"","service":"MCRLocalID","created":"2023-11-08T11:07:07.842Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00004458","type":"purl","additional":"","service":"RosDokPURL","created":"2023-11-08T11:07:07.851Z","registrationStarted":"2023-11-08T11:15:26.271Z"} {"identifier":"10.18453/rosdok_id00004458","type":"doi","additional":"","service":"RosDokDOI","created":"2023-11-08T11:07:07.854Z","registrationStarted":"2023-11-08T11:15:26.012Z","registered":"2023-11-08T11:15:27.532Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00004458-6","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2023-11-08T11:07:07.848Z","registered":"2023-11-09T08:02:37.937Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003068/rosdok_derivate_0000211917/Lupu_Dissertation_2023.pdfElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationgnd:1309108412orcid:0009-0003-5299-0907gnd:13860231Xgnd:1014052165orcid:0000-0001-9190-482Xgnd:1130680797gnd:38329-6gnd:1029510660gnd:1309108412orcid:0009-0003-5299-0907gnd:13860231Xgnd:1014052165orcid:0000-0001-9190-482Xgnd:1130680797gnd:38329-6gnd:1029510660rosdok_disshab_0000003068-d3258924e52gnd:1309108412orcid:0009-0003-5299-0907Loredana-Mirela LupuLoredana-Mirela Lupurosdok_disshab_0000003068-d3258924e68gnd:13860231XMarkus TiedgeMarkus Tiedgerosdok_disshab_0000003068-d3258924e83gnd:1014052165orcid:0000-0001-9190-482XMichael GlockerMichael Glockerrosdok_disshab_0000003068-d3258924e99gnd:1130680797Michael PrzybylskiMichael Przybylskirosdok_disshab_0000003068-d3258924e115gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003068-d3258924e126gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockLoredana-Mirela LupuMarkus TiedgeMichael GlockerMichael PrzybylskiUniversität RostockUniversitätsmedizin RostockLoredana-Mirela LupuMarkus TiedgeMichael GlockerMichael PrzybylskiUniversität RostockUniversitätsmedizin RostockLoredana-Mirela LupuRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004458urn:nbn:de:gbv:28-rosdok_id00004458-610.18453/rosdok_id00004458The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore, PROTEX-SPR-MS has been employed to study two distinct single-stranded DNA aptamers interacting with a tumor biomarker protein. This analysis has revealed that aptamers have remarkably similar affinity and epitope binding to antibodies, suggesting their potential utility in medical applications.20222022Enthält ZeitschriftenartikelMarkus Tiedge (Institut für Medizinische Biochemie und Molekularbiologie) ; Michael O. Glocker (Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung) ; Michael Przybylski (AffyMSLifeChem)[{"name":"Tiedge, Markus","affil":"Institut für Medizinische Biochemie und Molekularbiologie"},{"name":"Glocker, Michael O.","affil":"Universitätsmedizin Rostock und Naturwissenschaftliche Fakultät, Abteilung für Proteomforschung"},{"name":"Przybylski, Michael","affil":"AffyMSLifeChem"}]vorgelegt von Loredana-Mirela Lupu[xslt]Saxonrosdok/id00004458https://purl.uni-rostock.de/rosdok/id00004458186970480010.18453/rosdok_id00004458urn:nbn:de:gbv:28-rosdok_id00004458-6Loredana-Mirela LupuLupu Loredana-MirelaElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationDissertationdoctoral thesisUniversität Rostock, 2022The PROTEX-SPR-MS method has unveiled several epitopes with promising medical applications, including an epitope peptide suitable for antibody removal in Fabry's disease. Additionally, an epitope conducive to early heart muscle injury diagnosis was identified and characterized.Furthermore,…Loredana-Mirela LupuElucidation of molecular recognition structures of peptides and proteins to antibodies and DNA aptamers by biosensor- mass spectrometry combinationUniversitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004458Loredana-MirelaLupu1992 -VerfasserInaut13091084120009-0003-5299-0907MarkusTiedge1963 -AkademischeR BetreuerIndgs13860231XInstitut für Medizinische Biochemie und MolekularbiologieMichaelGlocker1960 -AkademischeR BetreuerIndgs10140521650000-0001-9190-482XMichaelPrzybylski1948 - 2023AkademischeR BetreuerIndgs1130680797AffyMSLifeChem38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00004458[urn]urn:nbn:de:gbv:28-rosdok_id00004458-6[doi]10.18453/rosdok_id00004458open_access20222022epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:500institution:unirostock.umrstate:published