10.18453/rosdok_id00004509 Abt-Becker, Corina Corina Abt-Becker http://d-nb.info/gnd/1314963953 Universität Rostock 2023 500 Natural sciences 570 Life science 2023 en https://purl.uni-rostock.de/rosdok/id00004509 urn:nbn:de:gbv:28-rosdok_id00004509-4 The pathogens Streptococcus pneumoniae and Streptococcus pyogenes can cause serious diseases. In this work effective carrier-coupled antisense peptide nucleic acids (PNAs) against S. pneumoniae were identified. The counteranion pyrenebutyrate was investigated for its ability to improve uptake of CPP-PNAs in streptococci. Furthermore, transcriptomic effects of CPP-PNA on streptococci were examined. As Galleria mellonella is an increasingly popular infection model organism, additionally the S. pyogenes specific immune response of the larvae was investigated using a proteomics approach.