mycoreobjectrosdok_disshab_0000003106rosdok_disshab_0000003106rosdokdisshabrosdok_derivate_00002165452024-01-06T11:00:04.388Z2024-01-05T10:56:20.348ZMCRJANITOReditorMSpublished1rosdok_derivate_0000216545truetruederivate_types:fulltextVolltextfulltextwf_edit_epub wf_register_epubstate:publishedstate:publishedveröffentlichtpublishedrosdok/id000045141877357669Oau2024-01-052024-01-05T11:01:05ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.8 [SCM: "0dd72eb2002cd5e1d4341cacf34e92f44f7894b4" "v2.8" "2023-10-12T16:45:19+0200"] with mode 'DEFAULT'.DissertationHochschulschriftMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionThe present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.Salem Oduro BeffiSueto1988 -VerfasserInaut13151383870000-0002-2829-8254GeorgFüllen1967 -AkademischeR BetreuerIndgs140626085MichealWalterAkademischeR BetreuerIndgsInstitut für Klinische Chemie und Laboratoriumsmedizin, Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Functional Bioinformatics, Örebro University, Örebro, Sweden38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004514urn:nbn:de:gbv:28-rosdok_id00004514-910.18453/rosdok_id00004514000 Allgemeines, Wissenschaft004 Informatik610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2023Universität RostockRostockmonographic202320232024Universitätsbibliothek RostockRostock2024Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004514Georg Fuellen (Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock) ; Micheal Walter (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock) ; Dirk Repsilber (Functional Bioinformatics, Örebro University, Örebro, Sweden)[{"name":"Fuellen, Georg","affil":"Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, Germany"},{"name":"Walter, Micheal","affil":"Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Functional Bioinformatics, Örebro University, Örebro, Sweden"}]vorgelegt von Salem Odura Beffi SuetoFuellen, GeorgInstitut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, GermanyWalter, MichealInstitut für Klinische Chemie und Laboratoriumsmedizin, Universität RostockRepsilber, DirkFunctional Bioinformatics, Örebro University, Örebro, Swedendoctype:epubdoctype:epubDokumenttypDocument typedoctype:epub.dissertationdoctype:epub.dissertationDissertationdoctoral thesisdiniPublType:doctoralThesis diniPublType2022:PhDThesis XMetaDissPlusThesisLevel:thesis.doctoralinfo:eu-repo/semantics/doctoralThesisdocumentnatureOfContent:ppn_105825778natureOfContent:ppn_105825778HochschulschriftdiniPublType2022:DoctoralThesisdiniPublType2022:DoctoralThesisDissertation oder HabilitationDoctoral thesisDRIVERdiniPublType2022:PhDThesisdiniPublType2022:PhDThesisDissertationPhD thesisKDSF (Pu34)XMetaDissPlusThesisLevel:thesis.doctoralXMetaDissPlusThesisLevel:thesis.doctoralDoktorarbeitdoctoral thesisSDNB:000SDNB:000000 Allgemeines, Wissenschaft000 Generalities, ScienceSDNB:004SDNB:004004 Informatik004 Data processing Computer sciencesSDNB:610SDNB:610610 Medizin, Gesundheit610 Medical sciences Medicineinstitution:unirostockinstitution:unirostockUniversität RostockUniversity of RostockUniversität RostockUniversität RostockUni.Rostockhttp://d-nb.info/gnd/38329-6institution:unirostock.umrinstitution:unirostock.umrUniversitätsmedizinUniversity MedicineUniversität Rostock. UniversitätsmedizinUniversitätsmedizinUni.Rostock.Fakultaet.MEDhttp://d-nb.info/gnd/1029510660licenseinfo:worklicenseinfo:workWerkworklicenseinfo:work.rightsreservedlicenseinfo:work.rightsreservedalle Rechte vorbehaltenall rights reserved/creativecommons/r/reserved/0.9/88x31.png[DE-28]Urheberrechtsschutz 1.0$gRights Statements$uhttp://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/http://rightsstatements.org/vocab/InC/1.0/licenseinfo:depositlicenseinfo:depositVeröffentlichungsgenehmigungpermission to storelicenseinfo:deposit.rightsgrantedlicenseinfo:deposit.rightsgrantedNutzungsrechte erteiltrights grantedlicenseinfo:metadatalicenseinfo:metadataLizenzen für Metadatenlicenseinfo:metadata.cc0licenseinfo:metadata.cc0Lizenz Metadaten: CC0license metadata: CC0/creativecommons/p/zero/1.0/88x31.pnghttps://creativecommons.org/publicdomain/zero/1.0/accesscondition:openaccessaccesscondition:openaccessfrei zugänglich (Open Access)open accesshttp://purl.org/coar/access_right/c_abf2OAfreeinfo:eu-repo/semantics/openAccess[DE-28]Open Access$gControlled Vocabulary for Access Rights$uhttp://purl.org/coar/access_right/c_abf2rfc5646:enrfc5646:enEnglischEnglishengengMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactiongnd:1315138387orcid:0000-0002-2829-8254gnd:140626085gnd:1065633742gnd:38329-6gnd:1029510660gnd:1315138387orcid:0000-0002-2829-8254gnd:140626085gnd:1065633742gnd:38329-6gnd:1029510660rosdok_disshab_0000003106-d2224091e52gnd:1315138387orcid:0000-0002-2829-8254Salem Oduro Beffi SuetoSalem Oduro Beffi Suetorosdok_disshab_0000003106-d2224091e68gnd:140626085Georg FüllenGeorg Füllenrosdok_disshab_0000003106-d2224091e82Micheal WalterMicheal Walterrosdok_disshab_0000003106-d2224091e93gnd:1065633742Dirk RepsilberDirk Repsilberrosdok_disshab_0000003106-d2224091e109gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003106-d2224091e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoGeorg FüllenMicheal WalterDirk RepsilberUniversität RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoGeorg FüllenMicheal WalterDirk RepsilberUniversität RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004514urn:nbn:de:gbv:28-rosdok_id00004514-910.18453/rosdok_id00004514The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.20232023Georg Fuellen (Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock) ; Micheal Walter (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock) ; Dirk Repsilber (Functional Bioinformatics, Örebro University, Örebro, Sweden)[{"name":"Fuellen, Georg","affil":"Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, Germany"},{"name":"Walter, Micheal","affil":"Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Functional Bioinformatics, Örebro University, Örebro, Sweden"}]vorgelegt von Salem Odura Beffi Suetoepub.dissertation1 Sueto_Dissertation_2024.pdf 21145073 af9868b56fa620128e154685e25d99f4 rosdok/id000045141877357669Oau2024-01-052024-01-05T11:01:05ZrdaConverted from PICA to MODS using Pica2MODS XSLT Transformer 2.8 [SCM: "0dd72eb2002cd5e1d4341cacf34e92f44f7894b4" "v2.8" "2023-10-12T16:45:19+0200"] with mode 'DEFAULT'.DissertationHochschulschriftMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionThe present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.Salem Oduro BeffiSueto1988 -VerfasserInaut13151383870000-0002-2829-8254GeorgFüllen1967 -AkademischeR BetreuerIndgs140626085MichealWalterAkademischeR BetreuerIndgsInstitut für Klinische Chemie und Laboratoriumsmedizin, Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Functional Bioinformatics, Örebro University, Örebro, Sweden38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgghttps://purl.uni-rostock.de/rosdok/id00004514urn:nbn:de:gbv:28-rosdok_id00004514-910.18453/rosdok_id00004514000 Allgemeines, Wissenschaft004 Informatik610 Medizin, GesundheitUniversitätsmedizinalle Rechte vorbehaltenNutzungsrechte erteiltLizenz Metadaten: CC0frei zugänglich (Open Access)en2023Universität RostockRostockmonographic202320232024Universitätsbibliothek RostockRostock2024Universitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004514Georg Fuellen (Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock) ; Micheal Walter (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock) ; Dirk Repsilber (Functional Bioinformatics, Örebro University, Örebro, Sweden)[{"name":"Fuellen, Georg","affil":"Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, Germany"},{"name":"Walter, Micheal","affil":"Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Functional Bioinformatics, Örebro University, Örebro, Sweden"}]vorgelegt von Salem Odura Beffi Sueto Fuellen, Georg Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, Germany Walter, Micheal Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock Repsilber, Dirk Functional Bioinformatics, Örebro University, Örebro, Sweden 2024-01-05T10:56:20.348Z 2024-01-06T11:00:04.388Z 2024-01-16T11:00:04.397Z editorMS {"identifier":"rosdok/id00004514","type":"local_id","additional":"","service":"MCRLocalID","created":"2024-01-05T10:56:20.362Z"} {"identifier":"https://purl.uni-rostock.de/rosdok/id00004514","type":"purl","additional":"","service":"RosDokPURL","created":"2024-01-05T10:56:20.372Z","registrationStarted":"2024-01-05T11:05:35.372Z"} {"identifier":"10.18453/rosdok_id00004514","type":"doi","additional":"","service":"RosDokDOI","created":"2024-01-05T10:56:20.375Z","registrationStarted":"2024-01-05T11:05:35.122Z","registered":"2024-01-05T11:05:36.540Z"} {"identifier":"urn:nbn:de:gbv:28-rosdok_id00004514-9","type":"dnbUrn","additional":"","service":"RosDokURN","created":"2024-01-05T10:56:20.369Z","registered":"2024-01-06T09:52:22.820Z"} MCRJANITORfulltextfile/rosdok_disshab_0000003106/rosdok_derivate_0000216545/Sueto_Dissertation_2024.pdfMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactiongnd:1315138387orcid:0000-0002-2829-8254gnd:140626085gnd:1065633742gnd:38329-6gnd:1029510660gnd:1315138387orcid:0000-0002-2829-8254gnd:140626085gnd:1065633742gnd:38329-6gnd:1029510660rosdok_disshab_0000003106-d2224091e52gnd:1315138387orcid:0000-0002-2829-8254Salem Oduro Beffi SuetoSalem Oduro Beffi Suetorosdok_disshab_0000003106-d2224091e68gnd:140626085Georg FüllenGeorg Füllenrosdok_disshab_0000003106-d2224091e82Micheal WalterMicheal Walterrosdok_disshab_0000003106-d2224091e93gnd:1065633742Dirk RepsilberDirk Repsilberrosdok_disshab_0000003106-d2224091e109gnd:38329-6Universität RostockUniversität Rostockrosdok_disshab_0000003106-d2224091e120gnd:1029510660Universitätsmedizin RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoGeorg FüllenMicheal WalterDirk RepsilberUniversität RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoGeorg FüllenMicheal WalterDirk RepsilberUniversität RostockUniversitätsmedizin RostockSalem Oduro Beffi SuetoRostockUniversität Rostockepub.dissertationhttps://purl.uni-rostock.de/rosdok/id00004514urn:nbn:de:gbv:28-rosdok_id00004514-910.18453/rosdok_id00004514The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.20232023Georg Fuellen (Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock) ; Micheal Walter (Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock) ; Dirk Repsilber (Functional Bioinformatics, Örebro University, Örebro, Sweden)[{"name":"Fuellen, Georg","affil":"Institut für Biostatistik und Informatik in Medizin und Alternsforschung, Universität Rostock, Germany"},{"name":"Walter, Micheal","affil":"Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Rostock"},{"name":"Repsilber, Dirk","affil":"Functional Bioinformatics, Örebro University, Örebro, Sweden"}]vorgelegt von Salem Odura Beffi Sueto[xslt]Saxonrosdok/id00004514https://purl.uni-rostock.de/rosdok/id00004514187735766910.18453/rosdok_id00004514urn:nbn:de:gbv:28-rosdok_id00004514-9Salem Oduro Beffi SuetoSueto Salem Oduro BeffiMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionDissertationdoctoral thesisUniversität Rostock, 2023The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use…Salem Oduro Beffi SuetoMicroarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interactionUniversitätsbibliothek Rostockhttps://purl.uni-rostock.de/rosdok/id00004514Salem Oduro BeffiSueto1988 -VerfasserInaut13151383870000-0002-2829-8254GeorgFüllen1967 -AkademischeR BetreuerIndgs140626085MichealWalterAkademischeR BetreuerIndgsInstitut für Klinische Chemie und Laboratoriumsmedizin, Universität RostockDirkRepsilber1971 -AkademischeR BetreuerIndgs1065633742Functional Bioinformatics, Örebro University, Örebro, Sweden38329-6Universität Rostock1419 -Grad-verleihende Institutiondgg1029510660Universitätsmedizin RostockGrad-verleihende Institutiondgg[purl]https://purl.uni-rostock.de/rosdok/id00004514[urn]urn:nbn:de:gbv:28-rosdok_id00004514-9[doi]10.18453/rosdok_id00004514open_access20232023epoch:21th_centuryrfc5646:endoctype:epub.dissertationaccesscondition:openaccessSDNB:000SDNB:004SDNB:610institution:unirostock.umrstate:published