Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction

10.18453/rosdok_id00004514 Sueto, Salem Oduro Beffi Salem Oduro Beffi Sueto http://d-nb.info/gnd/1315138387 https://orcid.org/0000-0002-2829-8254 Microarray transcriptomics analysis of Hutchinson-Gilford progeria genetic disease and the exploitation of dual RNA-seq technology to unveil host-pathogen interaction Universität Rostock 2023 000 Generalities, Science 004 Data processing Computer sciences 610 Medical sciences Medicine 2023 en https://purl.uni-rostock.de/rosdok/id00004514 urn:nbn:de:gbv:28-rosdok_id00004514-9 The present work uses transcriptomics data from the microarray platform to study the biological imprint of Hutchinson-Gilford progeria syndrome and other senescence processes such as telomere elongation. Literature review of drug repurposing analysis was conducted to find tools that use transcriptomics data as input. RNA-seq technology was used to simultaneously study the gene expression of both the host (human) and the pathogen (S. pyogenes and Influenza A virus). The host expression was used as input for drug repurposing analysis to identify potential drugs for anti-infective treatment.